This document provides information on the clinical approach and management of acute kidney injury (AKI). It discusses evaluating for pre-renal, renal, and post-renal causes of AKI using history, exam, labs, and imaging tests. Treatment involves supportive care including fluid management, electrolyte control, nutrition, and dialysis for severe cases. Specific complications of AKI like hyperkalemia, acidosis, and hypertension are also reviewed. The goal of management is to maintain homeostasis and prevent further kidney damage while the kidneys recover function.