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PREMATURITY AND ITS COMPLICATIONS
SINGI
OUTLINES
i. DEFINITIONS
ii. CLASSIFICATION
iii. RISK FACTORS
iv. CAUSES
v. CLINICAL PRESENTATION
vi. Ddx
vii. COMPLICATIONS
DEFINITION
• “Live born infants delivered before 37 wk from the 1st day of the last
menstrual period are termed premature “ by WHO
• Prematurity is associated with more M&M, compared to the full term
infants
• The lower the GA the more Complications increase
Birth weight and its related gestational age
CLASSIFICATION
• Classifications based upon GA:
Extremely preterm-GA <28 WKS
Very preterm(VPT) –GA 28-32 WKS
Moderate to Late preterm-GA btn 32 -37 WKS
Classifications based on BW:
Low birth weight(LBW) –BW<2500g
Very low birth weight(VLBW)-BW<1500g
Extremely low birth weight(ELBW)-BW<1000g
WHO
RISK FACTORS
Low socio-economic status
 H/o previous prematurity,or VLBW
Single-parent families
Teanage pregancies
Short interpregnancy interval
 Multiparity
Tobacco
Pediatrics blue prints 3rd edition
Causes of prematurity
• Fetal :
•
-Fetal distress
-Multiple gestation
-Erythroblastosis
- Congenital malformations
-Twin-twin blood transfusions
Intrauterine infection (TORCH, SYPHILIS)
Nelson Textbook of pediatric 20th edition (P.1102)
Uterine causes
Nelson Textbook of pediatric 20th edition (P.1102)
Causes of prematurity
• Maternal
• Preeclampsia
• Malnutrition and anemia
• Chronic medical illness (cyanotic heart disease, diabetes, HTN, renal disease)
• Infection (GBS, malaria, UTI, Chorioamnitis….
• Drug abuse (cocaine)
Pediatrics blue prints 3rd edition
Causes of prematurity
• Other
• Premature rupture of membranes
• Polyhydramnios
• Iatrogenic
• Trauma
Pediatrics blue prints 3rd edition
CLINICAL PRESENTATION
• Weak or absent moro reflex, sucking and grasping may be extended
due to poor tone
The new BALLARD SCORE,
Best- <12hrs( <26 wks)
upto 96 hrs( >26 wks)
DDX
• Fetal growth restriction
medscape
NEONATAL PROBLEMS ASSOCIATED WITH
PREMATURE INFANTS
RESPIRATORY
Respiratory distress syndrome (hyaline membrane disease,)
Pneumothorax, and baro trauma when providing oxygen
Congenital pneumonia
Apnea, immature respiratory centre
Nelson Textbook of pediatric 20th edition (P.1104)
CARDIOVASCULAR
Patent ductus arteriosus
Hypotension
Bradycardia (with apnea)
Nelson Textbook of pediatric 20th edition (P.1104)
19
• Hematologic
•Anemia (early or late onset)
•Disseminated intravascular coagulopathy
•Vitamin K deficiency
GASTROINTESTINAL
Poor gastrointestinal function—poor motility
Necrotizing enterocolitis
Hyperbilirubinemia—direct and indirect
Nelson Textbook of pediatric 20th edition (P.1104)
METABOLIC -ENDOCRINE
Hypocalcemia
Hypoglycemia
Hyperglycemia
Hypothermia
Nelson Textbook of pediatric 20th edition (P.1104)
CNS
Intraventricular hemorrhage
Seizures
Retinopathy of prematurity
Deafness
Hypotonia
Nelson Textbook of pediatric 20th edition (P.1104)
RENAL
Hyponatremia
Hypernatremia
Hyperkalemia
Renal tubular acidosis
Renal glycosuria
Edema
Nelson Textbook of pediatric 20th edition (P.1104)
INFECTIONS
Congenital
Perinatal
Nosocomial: bacterial, viral, fungal,protozoal
Nelson Textbook of pediatric 20th edition (P.1104)
LONG TERM COMPLICATIONS
• Recurrent hospitalisations
• Broncho pulmonary displasia
• Retinopathy of prematurity
• Poor growth due to feeding problems, vit& Iron defociency
• CNS dysfunction, CP, Learning difficulty, deafness, hydrocephalus
uptodate
CARE AFTER BIRTH
The presence of a pediatrician in delivery room is very important
 Initiate breathing (resuscitation may be needed)
 Care for the umbilical cord
 Eye prophylaxis
 Vit K
 Thermal regulation » »36.5- 37.0°c +head cap+KMC
 Monitoring (HR and saturation)
 Oxygenotherapy
 Feeding, 105-130 kcal/kg/day, hypoglycemia below 40mg/dl in 48h and then below 50
 Discuss with mother on complications of prematurity
Nelson Textbook of pediatric 20th edition (P.1104)
REFERENCE
• Nelson textbook of pediatrics
• Medscape
Thank you

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Prematurity and its complication

Editor's Notes

  1. Families of low socioeconomic status have higher rates of maternal undernutrition, anemia, and illness; inadequate prenatal care; drug misuse; obstetric complications
  2. BACTERIAL INFECTIONS may initiate preterm labor by production of local inflammatory mediators (interleukin-6, prostaglandins), which may induce premature uterine contractions or a local inflammatory response with focal amniotic membrane rupture.