This document provides information on Stoply & Kaven Creams for acne treatment. It first discusses acne, its causes, classifications, and stages. It then details the ingredients and effects of Kaven Cream, which contains tea tree oil, propolis, and vitamins to fight bacteria, reduce inflammation, and moisturize skin. Stoply Cream is also described, containing salicylic acid, sulfur, and glycerin to exfoliate skin and control sebum production. Both creams aim to manage acne by removing dirt and bacteria from pores.

1. Stoply & Kaven Creams
MARKETING DEPARTMENT

3. Skin Acne
Acne
• Acne vulgaris is a common skin disease that affects 85-
100% of people at some time during their lives.
• It is characterized by no inflammatory follicular papules
or comedones and by inflammatory papules, pustules,
and nodules in its more severe forms.

4. Skin Acne
Acne
• Acne is a chronic inflammatory disease of the pilosebaceous unit resulting
from androgen-induced increased sebum production, altered
keratinization, inflammation, and bacterial colonization of hair follicles on
the face, chest, and back by Propionibacterium acnes.
• According to the Global Burden of Disease (GBD) study, acne vulgaris
affects about 85% of young adults aged 12–25 years. Acne consistently
represents the top three most prevalent skin conditions in the general
population.

5. Acne lesions
Macule: flat lesion due to a localized color change only; the surface is
normal (size<1cm)
Patch: similar to a macule but the size (> 1cm)
Nodule: any elevated lesion (> 1cm diameter) which has a round surface
(i.e. the thickness is similar to the diameter): often due to dermal
pathology
Plaque: (size > 1cm) a raised lesion where the diameter is much greater
than the thickness
Vesicle: (size < 1cm) a fluid filled lesion (blister)
Bullae: blister which is > 1cm in size
Pustule when a vesicle contains pus and the size is < 1cm and if it is more
than 1cm it is called abscess.

6. • Inflammatory lesions,
• Comedones formation,
• Hyperkeratosis
Secretion of inflammatory
mediators (eg; interlukines)
Formation Of ROS
Inflammation
Hyperkeratosis
Excessive androgen hormones
Abnormalities of sebaceous glands
Sebum hyper-secretion & abnormalities
Skin barrier function is impaired
Colonization of skin flora (eg; P.acnes)
Acne

7. Acne
Inflammation
P Acne
Follicular
hyperkeratosis
Seborrhea
key factors are responsible for the development of an acne lesion:
Skin Acne

8. Increased Sebum Production
• Increased production of androgenic hormones
• Increased sensitivity in the target organs to normal amount of androgen
in the body , so sebum overproduction leads to oiliness of the skin
specially face and scalp.

9. Hyperkeratosis
• Increase Sebum leads to change in keratinization .
• Increase in turnover of production of horny cell layer, these cells stick
together tightly to form a solid mass which block the orifice and forcing
sebum to accumulate inside the seb.follicle---Comedon formation

10. Propionebacterium Acnes
Propionibacterium acnes is a member of the resident cutaneous flora.
Sebaceous follicles involved in acne are characterized by the
accumulation of abnormally desquamated corneocytes and excess
sebum-the microcomedo. This environment provides ideal growth
conditions for P acnes. Several orders of magnitude level of P acnes are
found in microcomedos. P acnes produces a variety of chemotactic
factors and proinflammatory molecules that are responsible for the
inflammatory phase of acne.

11. Inflammation
Localized response to tissue injury and invading Microorganism.
Characterized by redness , hotness
In it, occur removal of foreign cells and debris and tissue repair

12. Genetic predisposition – but mode of inheritance is unknown
Mechanical factors – excessive rubbing of the skin and use of oily
cosmetics may induce acne lesion.

13. Classifications of acne
Acne can be classified into three categories
Comedonal ,inflammatory & nodulocystic.
Acne can be classified into
mild, moderate or severe.

14. Stages of acne lesion
Stage One: Comedones
The first stage of acne involves comedones (blackheads and whiteheads) to
forming on skin.
In this stage, the pores in your skin get clogged by dead skin cells, which
prevent sebum from being secreted to protect skin. When the sebum
cannot release, it starts to fill pores.

15. Closed comedones (called whiteheads) develop when the mixture of dead
cells and sebum remain trapped underneath the surface of skin.
Opened comedones (called a blackhead) develops when pore opens up to
the surface and the sebum gets oxidized, turning it into a brown or black
color.

20. Stage Two: Small Bumps
In the second stage of acne,
papules begin to appear on skin.
Papules are small.
Solid bumps that are slightly
elevated on skin.

22. Stage Three: Pimples
Pustules (also called pimples) develop a few days
later in the third stage. Pimples form after
inflammation causes white blood cells to rush in
to fight "P. acne" on the surface of skin.
The breakout of pimples is a severe form of acne.
Pimples can burst or collapse, which inflames the
skin surrounding them.

24. Stage Four: Cysts & Nodules
Pimples burst or collapse, the
surrounding skin gets inflamed, which
causes nodules and cysts to form.

27. Acne scar
Acne scars fall under two categories:
1-Those caused by a loss of tissue (atrophic)
2- Those caused by an excess of tissue
(hypertrophic)

28. Within these categories, acne scars fall into one of four types:

29. pH For Skin
• Normal skin pH ranges from 4.5 to 6.5, which means it is always on the
slightly acidic.
• This acidity of the skin is termed the “acid mantle” and is maintained by
sebaceous glands, sweat glands, normal skin flora.
• It serves many protective functions to the skin, one of which is killing
unwanted bacteria.
• People suffering from acne have a slightly higher skin pH, and that
bringing it down helps control acne.

30. If it is alkaline (or neutral)
The stratum corneum (uppermost layer of the skin) is disrupted, damaging the
barrier function of the skin, which translates into skin dryness and decreased
antibacterial defense.
for acids
Applying a mildly acidic product actually soothes the skin, helping it retain moisture
and strengthening the skin barrier even more.

31. Acne Management
The goal of acne management
• Tackles follicular hyper proliferation
• Reduces hyperkeratosis
• Reduces excessive sebum secretion
• Fight inflammation caused by P acne.

32. RETIN-A (TRETINOIN )
• Tretinoin is an acid form of vitamin A. When it is delivered to the skin, it
stimulates normal maturation of cells in the epidermis of the skin. Right as it
does, it activates genes that cause them to live out a 21-day life cycle during
which they are pushed to the surface of the skin.
• Tretinoin stimulates skin growth around the clogged pore. The pore opens
naturally with squeezing, tweezing, picking, poking, steaming, or detergent
treatment.
• Topical Tretinoin is not recommended for children under the age of 12, or for
women who are or who may become pregnant, or who are nursing.

33. ADAPALENE
• Treating severe acne Adapalene, which is a form of vitamin A used in the
treatment of acne.
• Adapalene reduces the growth of the keratin surface skin cells that can
block pores. This helps to unblock the pores and sebaceous glands
(glands which secrete sebum) and as a result the sebum can escape. This
reduces the formation of blackheads (comedones) and spots.
• Common side effects (affect between 1 in 10 and 1 in 100 people)
• Dry skin.
• Skin irritation.
• Burning sensation of the skin.
• Redness of skin.

34. BENZOYL PEROXIDE
• Benzoyl peroxide has an antibacterial effect. It also has a mild drying
effect, which allows excess oils and dirt to be easily washed away from
the skin.
• Sodium hyaluronate is a lubricant that restores moisture to the skin.
• Benzoyl peroxide and sodium hyaluronate topical (for the skin) is a
combination medicine used to treat severe acne along with dry or scaly
skin.
common side effects may include:
• redness or peeling of treated skin;
• mild burning or stinging; or
• dry skin.

36. KAVEN CREAM

37. KAVIN CREAM
INGREDIENTS
• TEA TREE OIL
• PROPOLIS
• CHLORHEXIDINE
• TRICLOSAN
• SALICYLIC ACID
• CHAMOMILE
• VITAMIN E
• VITAMIN A
• ALLANTOIN
• OLIVE OIL
• GLYCERIN
• PANTHENOL

38. KAVIN CREAM
• Broad Spectrum Anti-Septic Effect.
• (TEA TREE OIL – PROPOLIS - CHLORHEXIDINE - TRICLOSAN)
Kaven Cream….. Has broad spectrum anti-septic effects against a wide
range of bacteria in the skin.

39. KAVIN CREAM
• Powerful Keratolytic Agent (SALICYLIC ACID).
Kaven Cream….. Removes dead skin cells and cleanses deeply through the
pores which contain sebum.
Kaven Cream….. Prevents clogging of pores & removes sweat, sebum,
micro- organisms, dead cells & makeup residues.

40. KAVIN CREAM
• Anti-Inflammatory & Anti-Oxidant Effect (PROPOLIS – CHAMOMILE - VITAMIN E – VITAMIN A)
• Kaven Cream….. Has powerful anti-inflammatory effect & antioxidant
activity which scavenges the free radicals, reduces photo damage and
skin barrier function impairment.

41. KAVIN CREAM
• Excellent Moisturizing Effect (ALLANTOIN – OLIVE OIL – GLYCERIN - PANTHENOL)
• Kaven Cream….. Sooths, moisturizes the skin and increases total water
contents in epidermis, improves the barrier function and reduces skin
irritation.

42. KAVIN CREAM
• Kaven Cream… Unique effective anti-proliferative & seboregulatory
formula which removes dirt, sweat, sebum, micro- organisms, dead cells
& makeup.
• Kaven Cream… Has mild exfoliating effect and potent anti-microbial &
anti-inflammatory effect.
• Kaven Cream… Helps getting rid of acne lesions and restoring skin healthy
appearance.
• Kaven Cream… Skin cream without over drying leaving a thin moisturizing
film on the skin.
• Kaven Cream…Compatible with topical and systemic therapies.

43. KAVIN CREAM
INDICATIONS
• Manages all cases & forms of acne.
• Protects from further breakouts of acne.
• Controls excessive sebum secretions in oily & sensitive skin.
• Manages acne spots & scars.
•
UTILIZATION
• Apply Kaven Cream to the affected area twice daily over the affected area
without rubbing then leave for 30 minutes or as prescribed by physician.

49. STOPLY CREAM

50. STOPLY CREAM
INGREDIENTS
• SALICYLIC ACID
• SULFUR
• CASTOR OIL
• GLYCERIN
• PANTHENOL

51. STOPLY CREAM
• Chemical peeling is a safe, efficacious, and cost-effective procedure for
treating various skin disorders and for enhancing cosmetic appearance.
• The principle of peeling involves controlled chemical injury to the skin in
order to prompt it to rejuvenate, leading to smoothening of the skin and
improvement of its surface texture.

52. STOPLY CREAM
• Stoply Cream plays an important role in treating superficial conditions
including melasma, acne, and dyschromia & also medium-depth peels
such as solar keratosis, dyschromia, and pigment disorders.

53. STOPLY CREAM
• Potent Keratolytic & Peeling Effect (SALICYLIC ACID – SULFUR).
Stoply Cream … Keratolytic treatment that corrects established blemishes,
smoothers and refines the skin texture through the effective peeling effect.
Stoply Cream … Removes dead skin cells due to its potent peeling effect &
clears clogged pores of oils and micro-grains to control acne and restore
clarity.

54. STOPLY CREAM
• Improves Skin Conditions (CASTOR OIL – GLYCERIN - PANTHENOL).
Stoply Cream … Sooths the sensation of burning, stinging and skin irritation.

55. STOPLY CREAM
INDICATIONS
• All cases that require peeling agents such as (acne lesions, blemishes, dyschromia)
UTILIZATION
• Apply Stoply Cream to the affected area twice daily over the affected area without
rubbing then leave for 30 minutes or as prescribed by physician.