This document discusses absolute and relative bioavailability. Absolute bioavailability is determined for the same drug in various formulations and measures the actual percentage of an administered non-intravenous dose that is absorbed into systemic circulation relative to an equivalent intravenous dose. Relative bioavailability compares drug exposures following extravascular administration to that of intravenous administration and is used to characterize a drug's inherent absorption properties from extravascular sites. Relative bioavailability compares the bioavailability of formulations of the same drug, usually to an established standard formulation.

1. ABSOLUTE
BIOAVAILABILITY &
RELATIVE
BIOAVAILABILITY
PRESENTED BY:
Mahesh Gomasa
PharmD-IV year
BHARAT SCHOOL OF PHARMACY
Hyderabad
PRESENTATION
ON

2. It is determined for the same drug in variuos
formulations.
Measurement of actual percetage of the adminisered
(non-intravenous)dose,which is absorbed intact into the
systemic circulation relative to equivalent IV dose.
1)
2)

3. Compares drug exposures following extravascular
administration of the tested dose form with that of an
intravenous administration.
Used to charecterise a drug’s inherent absorption
properties from extravascular site.
Example : Comparative study of bioavailability of a
drug given through oral route and IV route.
3)
4)

4. 4
It is determined for the various drugs
Measure of fraction of a given drug that is absorbed intact into
systemic circulation from a dosage form relative to an established
standard dosage form ofthat drug.
Compare bioavailability of a formulation(X) of the same drug
(usually established standard)
1)
2)
3)

5. Used to charecterise absorption of a drug from its formulation
5
Example : Generic formulation is compared with a standard formulation of
same drug in same dosage form.
4)

6. REFERENCES :
6
Www.Amrita Akhouri.com
www.Google.com

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