Content will be helpful for B.Sc. and M.Sc. nursing students as it describes causes, signs and symptoms, diagnosis,emergency mangement , medical and nursing management.
Content will be helpful for B.Sc. and M.Sc. nursing students as it describes causes, signs and symptoms, diagnosis,emergency mangement , medical and nursing management.
CHEST INJURY- BLUNT/ Trauma Surgery
Dear viewers,
Greetings from “Surgical Educator”
Today I have uploaded a video on CHEST INJURY- BLUNT- an important topic in trauma. Even the blunt chest trauma can turn into penetrating one because of jagged edges of the broken ribs. I haven’t talked elaborately but have included the essential minimum an undergraduate medical student should know. I have talked about pathophysiology, clinical approach, symptoms, signs, investigations, different individual types of Chest injuries and management of all the varieties of Chest injuries. My aim is, after watching this video all of you should be able to arrive at a correct working diagnosis of the type of chest injury and should also be able to institute immediate lifesaving treatment to the patients if there is a need. You can watch the video in the following links:
surgicaleducator.blogspot.com
youtube.com/c/surgicaleducator
Thank you for watching the video.
Splenic trauma - Causes, Complications, ManagementVikas V
Splenic Trauma - A detailed Presentation about Splenic Trauma, anatomy of the spleen, Causes of Trauma, Mechanism of Injury, Diagnosis, Management, Surgical management, Steps of Splenectomy, and Complications
CHEST INJURY- BLUNT/ Trauma Surgery
Dear viewers,
Greetings from “Surgical Educator”
Today I have uploaded a video on CHEST INJURY- BLUNT- an important topic in trauma. Even the blunt chest trauma can turn into penetrating one because of jagged edges of the broken ribs. I haven’t talked elaborately but have included the essential minimum an undergraduate medical student should know. I have talked about pathophysiology, clinical approach, symptoms, signs, investigations, different individual types of Chest injuries and management of all the varieties of Chest injuries. My aim is, after watching this video all of you should be able to arrive at a correct working diagnosis of the type of chest injury and should also be able to institute immediate lifesaving treatment to the patients if there is a need. You can watch the video in the following links:
surgicaleducator.blogspot.com
youtube.com/c/surgicaleducator
Thank you for watching the video.
Splenic trauma - Causes, Complications, ManagementVikas V
Splenic Trauma - A detailed Presentation about Splenic Trauma, anatomy of the spleen, Causes of Trauma, Mechanism of Injury, Diagnosis, Management, Surgical management, Steps of Splenectomy, and Complications
Presentation on the management of abdominal injuries including the causes of abdominal injuries; the classification of abdominal injuries; the initial management of patients with abdominal injuries according to the ATLS; trauma laparotomy
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. Introduction
• One of the leading cause of death and disability.
• Identification of serious intra-abdominal injuries
is often challenging.
• Peak incidence of abdominal trauma is 15-30
years.
• Injury accounts for 15-20% of all trauma deaths.
• Uncontrolled haemorrhage - major cause of
death immediately after abdominal trauma.
• Most common delayed cause of mortality and
morbidity following abdominal trauma is sepsis.
6. Pre-hospital care
• Goal – deliver the patient to hospital for
definitive care as soon as possible.
Scoop and Run
• ABC & care of spinal cord
• Start IV line
• Communicate to medical control
• Rapid transport of patient to trauma centre
7. Primary Survey (ATLS protocol)
• Airway with cervical spine protection
• Breathing and ventilation
• Circulation with hemorrhage control
• Disability : neurologic status
• Exposure/Environment control
8. Adjuncts to primary survey
• ECG monitoring
• Urinary catheter
• Gastric catheter
• Monitoring
– ABG
– Pulse oximeter
– Blood pressure
• X-rays
– AP CXR
– AP PELVIS
– C-SPINE
• DPL
• ABD USG - FAST
9. Secondary Survey (ATLS protocol)
• Head to toe evaluation
• Complete history and physical examination
• Reassessment of all vital signs
• Complete neurological examination
• Indicated x-rays are obtained
• Special procedures
• Tubes and fingers in every orifice
10. Secondary Survey (ATLS protocol)
AMPLE history
• Allergies
• Medications
• Past illness/Pregnancy
• Last meal
• Events/Environment related to injury
17. Solid Visceral Injury
• Splenic Injury
– most common (40-55%)
– 20% occur due to left lower rib fracture
• Liver Injury
– 2nd
most common (35-45%)
– 50% liver injury stop bleeding spontaneously by
the time of surgery
– Mortality 10%
18. Clinical Feature -Abdominal Injury
Gastrointestinal Injuries
• Incidence – 1-12%
• Perforation of stomach, small bowel and
colon.
• Gastric injuries cause chemical irritation.
• Small bowel and colonic injuries cause
suppurative peritonitis.
• Inflammation may take 6-7 hours to develop.
19. Clinical Feature - Abdominal Injury
Retroperitoneal Injuries
• Pancreatic Injuries
• 4% of patient with abdominal trauma.
• No specific signs and symptoms.
• Mechanism of injury – rapid deceleration
• Duodenal injuries
• Relatively asymptomatic on presentation – small
hematomas may go undiagnosed.
• Gastric outlet obstruction
• Duodenal rupture – high velocity deceleration
20. Clinical Feature - Abdominal Injury
• Kidney injuries
– 10% patients with abdominal trauma
– Injuries consist of lacerations, avulsions and
hematomas to the kidney itself and renal pelvis
– Renal vascular injuries are uncommon
21. Renal Injury Scale
Grade Description
I Hematuria with normal anatomic studies (contusion) or subcapsular,
nonexpanding hematoma; no laceration
II Perirenal, nonexpanding hematoma or <1 cm renal cortex laceration
with no urinary extravasation
III >1 cm renal cortex laceration with no collecting system involvement
or urinary extravasation
IV Laceration through cortex and medulla and into collecting system or
segmental renal artery or vein injury with hematoma
V Shattered kidney or vascular injury to renal pedicle or avulsed
kidney
22. Clinical Feature - Abdominal Injury
• Ureteral Injury
– Isolated urethral injury is rare in trauma
– Penetrating trauma – 90% & blunt trauma 10%
– 70% cases will have gross or microscopic
hematuria
23. Clinical Feature - Abdominal Injury
• Bladder Injury
– 2% of blunt abdominal trauma
– 70-97% associated with pelvic fracture
– Lower abdominal pain, tenderness and gross
hematuria
– Lower abdominal bruising, abdominal swelling from
urinary ascites, perineal or scrotal edema from
urinary extravasation, and inability to void
– secondary to penetrating trauma - injuries to the
rectum or buttocks.
24. Clinical Feature - Abdominal Injury
Urethral Injury – Anatomical Classification
• Posterior urethral injuries
– Major blunt force trauma- rapid deceleration
mechanism
– Triad of urinary retention, blood at the meatus
and high riding prostate.
– 10% of patients with pelvic fractures.
• Anterior urethral injuries
– Direct perineal trauma – blunt / penetrating
– Straddle injury is classic mechanism
– Can also occur with penile fracture
25. Clinical Feature - Abdominal Injury
Diaphragmatic Injuries
• Diaphragm spasm – secondary to direct blow
to epigastrium.
• Diaphragmatic rupture – penetrating trauma
or blunt force mechanism.
• Failure to diagnose – delayed herniation or
strangulation hernia of abdominal contents.
27. Diagnosis
Abdominal injuries that need expanded evaluation
Prasence of pain, tenderness, distention and external signs of trauma
Mechanism of injury with a high likelihood of causing abdominal injury
Suspicious lower chest, back or pelvic injury.
Inability to tolerate of delayed diagnosis
Presence of distracting injuries
Altered consciousness/sensorium
40. CT Scan – Splenic injury
CT shows a subcapsular hematoma with a splenic laceration extending from
the capsule to the hilum with an intraparenchymal hematoma (blue arrow)
41. CT Scan – Splenic injury
This CT shows Rupture of the anterior half of the spleen caused by blunt
trauma.Haemorrhage is seen within the splenic bed (arrow)
42. CT Scan – Kidney injury
Left kidney multiple lacerations
43. CECT Scan – Ureter injury
Right ureteric injury from penetrating rauma
53. Treatment
• Gold standard - LAPAROTOMY
Indications for LAPAROTOMY
Blunt Penetrating
Absolute
Ant. Abdominal wall injury with
hypotension
Injury to abdomen, back and flank with
hypotension
Abdominal wall disruption Abdominal tenderness
Peritonitis GI evisceration
Free air under diaphragm on cxr High suspicion of trans abdominal
trajectory after gunshot wound
Positive FAST/DPL in hemodynamically
unstable patient
CT diagnosed injury requiring surgery
CT diagnosed injury requiring surgery
Relative
Positive FAST/DPL in hemodynamically
stable patient
Positive local wound exploration after
stab wound.
Solid visceral injury in stable patient
Hemoperitoneum on CT without clear
source
54. Non-operative management of blunt
trauma
• Patient hemodynamically stable after initial
resuscitation.
• Continious patient monitoring for 48 hrs
• Surgical team immediately available.
• Adequate ICU support and transfusion
services available.
• Absence of peritonitis.
• Normal sensorium.
• Angioembolization may be an alternative to
surgery
55. Reference
• Tintinallis Emergency Medicine – 8th
edition
• Advanced Trauma Life Support Guidelines
• Eastern Association for the Surgery of Trauma
Guidelines
• Abdominal trauma imaging –
www.intechopen.com