- Vitamin B1, also known as thiamine, is a water-soluble vitamin that plays a key role in energy metabolism as a cofactor. Deficiency can cause beriberi disease.
- Vitamin B2 or riboflavin is another water-soluble B vitamin that is involved in energy production through its roles as the coenzymes FMN and FAD.
- The document discusses the classification, functions, deficiency and sources of several B vitamins and fat-soluble vitamins A, D, E, and K. It provides details on their roles in biological processes and metabolism.
Casimir Funk discovered vitamin B1 in rice bran in 1912 and coined the term "vitamin". Vitamins are organic compounds required as nutrients in small amounts that cannot be synthesized by the body and must come from diet. They have diverse biological functions including hormone regulation, cell growth, and acting as antioxidants or enzyme cofactors. Vitamins are classified as either lipid-soluble like A, D, E, K which are absorbed with fats, or water-soluble like the B vitamins and C which dissolve in water and must be consumed daily.
The document discusses vitamins, including their classification, functions, sources, and deficiencies. It covers key details about vitamins A, D, E, K, B1, and B2. Specifically, it describes:
- Vitamins are organic compounds required as nutrients and cannot be synthesized in sufficient quantities. They are classified as lipid-soluble or water-soluble.
- Vitamin A is important for vision, cell differentiation, and immune function. Deficiency can cause night blindness and increased infection risk.
- Vitamin D regulates calcium and phosphate levels and is synthesized from sunlight exposure. It supports bone and immune health.
- Vitamin E is a powerful antioxidant that protects cell membranes from free radical damage.
Vitamins are organic compounds that cannot be synthesized by the human body and must be obtained through diet. This document discusses several key vitamins:
- Vitamin A supports vision, cell differentiation, and reproduction. It exists in retinol form in animals and beta-carotene form in plants. Deficiency can cause night blindness and increased infection risk.
- Vitamin D aids in calcium absorption and bone mineralization. It is produced endogenously from sunlight or obtained through diet. Deficiency causes rickets in children and osteomalacia in adults.
- Vitamin K acts as a coenzyme in blood clotting by allowing the carboxylation of clotting factors. Def
Vitamins are organic compounds that are required in small amounts for normal growth, maintenance and reproduction. Vitamin A is important for vision, growth, and epithelial cell maintenance. It can be found in animal foods like liver and plant foods like carrots. Too much vitamin A can cause toxicity. Vitamin D aids in calcium absorption and is synthesized from cholesterol when skin is exposed to sunlight. It helps maintain adequate calcium and phosphorus levels. Vitamin E is an antioxidant that protects cell components from oxidative damage. It exists as tocopherols with alpha-tocopherol being the most active form.
This document discusses vitamins, specifically focusing on vitamin A. It begins by defining vitamins and describing their diverse biological functions. It then discusses vitamin A in more detail, covering its chemistry, sources, recommended dietary allowance, absorption and transport, key biochemical functions including in vision and cell differentiation, deficiency and toxicity manifestations. The summary highlights that vitamin A plays important roles in vision, bone growth, reproduction and as an antioxidant, and deficiencies can cause night blindness while too much can be toxic.
vitamin classification with fat soluble and water soluble vitamins ,vitamin A sources ,digestion, absorption along with biochemical functions, Recommended Dietary Intake, Deficiency, Hypervitaminosis
Vitamin D is a prohormone that is derived from cholesterol and activated by enzymes in the liver and kidney. It exists in two forms: D3 which comes from animals and D2 which comes from plants. Vitamin D's main functions are to regulate blood calcium levels by increasing calcium absorption in the intestines and bones. It also helps absorb phosphorus and promotes bone formation. A lack of vitamin D can lead to rickets in children and osteomalacia in adults, while too much can cause calcium deposits in soft tissues and hypercalcemia. Good sources include fatty fish, beef, eggs and fortified foods like milk.
This document provides information about vitamins A and D, including their structures, functions, dietary sources, absorption and transport in the body, and deficiency diseases. It discusses that both vitamins A and D are fat-soluble and absorbed along with dietary fat in the small intestine. Vitamin A supports vision, growth, immune function and reproduction, while vitamin D works with parathyroid hormone and calcitonin to regulate calcium and phosphorus levels in the blood and support bone mineralization. Deficiencies of vitamins A and D can lead to conditions like night blindness, rickets, osteomalacia, and increased susceptibility to infections.
Casimir Funk discovered vitamin B1 in rice bran in 1912 and coined the term "vitamin". Vitamins are organic compounds required as nutrients in small amounts that cannot be synthesized by the body and must come from diet. They have diverse biological functions including hormone regulation, cell growth, and acting as antioxidants or enzyme cofactors. Vitamins are classified as either lipid-soluble like A, D, E, K which are absorbed with fats, or water-soluble like the B vitamins and C which dissolve in water and must be consumed daily.
The document discusses vitamins, including their classification, functions, sources, and deficiencies. It covers key details about vitamins A, D, E, K, B1, and B2. Specifically, it describes:
- Vitamins are organic compounds required as nutrients and cannot be synthesized in sufficient quantities. They are classified as lipid-soluble or water-soluble.
- Vitamin A is important for vision, cell differentiation, and immune function. Deficiency can cause night blindness and increased infection risk.
- Vitamin D regulates calcium and phosphate levels and is synthesized from sunlight exposure. It supports bone and immune health.
- Vitamin E is a powerful antioxidant that protects cell membranes from free radical damage.
Vitamins are organic compounds that cannot be synthesized by the human body and must be obtained through diet. This document discusses several key vitamins:
- Vitamin A supports vision, cell differentiation, and reproduction. It exists in retinol form in animals and beta-carotene form in plants. Deficiency can cause night blindness and increased infection risk.
- Vitamin D aids in calcium absorption and bone mineralization. It is produced endogenously from sunlight or obtained through diet. Deficiency causes rickets in children and osteomalacia in adults.
- Vitamin K acts as a coenzyme in blood clotting by allowing the carboxylation of clotting factors. Def
Vitamins are organic compounds that are required in small amounts for normal growth, maintenance and reproduction. Vitamin A is important for vision, growth, and epithelial cell maintenance. It can be found in animal foods like liver and plant foods like carrots. Too much vitamin A can cause toxicity. Vitamin D aids in calcium absorption and is synthesized from cholesterol when skin is exposed to sunlight. It helps maintain adequate calcium and phosphorus levels. Vitamin E is an antioxidant that protects cell components from oxidative damage. It exists as tocopherols with alpha-tocopherol being the most active form.
This document discusses vitamins, specifically focusing on vitamin A. It begins by defining vitamins and describing their diverse biological functions. It then discusses vitamin A in more detail, covering its chemistry, sources, recommended dietary allowance, absorption and transport, key biochemical functions including in vision and cell differentiation, deficiency and toxicity manifestations. The summary highlights that vitamin A plays important roles in vision, bone growth, reproduction and as an antioxidant, and deficiencies can cause night blindness while too much can be toxic.
vitamin classification with fat soluble and water soluble vitamins ,vitamin A sources ,digestion, absorption along with biochemical functions, Recommended Dietary Intake, Deficiency, Hypervitaminosis
Vitamin D is a prohormone that is derived from cholesterol and activated by enzymes in the liver and kidney. It exists in two forms: D3 which comes from animals and D2 which comes from plants. Vitamin D's main functions are to regulate blood calcium levels by increasing calcium absorption in the intestines and bones. It also helps absorb phosphorus and promotes bone formation. A lack of vitamin D can lead to rickets in children and osteomalacia in adults, while too much can cause calcium deposits in soft tissues and hypercalcemia. Good sources include fatty fish, beef, eggs and fortified foods like milk.
This document provides information about vitamins A and D, including their structures, functions, dietary sources, absorption and transport in the body, and deficiency diseases. It discusses that both vitamins A and D are fat-soluble and absorbed along with dietary fat in the small intestine. Vitamin A supports vision, growth, immune function and reproduction, while vitamin D works with parathyroid hormone and calcitonin to regulate calcium and phosphorus levels in the blood and support bone mineralization. Deficiencies of vitamins A and D can lead to conditions like night blindness, rickets, osteomalacia, and increased susceptibility to infections.
A vitamin is an organic compound and a vital nutrient that an organism requires in limited amounts. An organic chemical compound (or related set of compounds) is called a vitamin when the organism cannot synthesize the compound in sufficient quantities, and it must be obtained through the diet; thus, the term "vitamin" is conditional upon the circumstances and the particular organism.
This document discusses disorders related to vitamin deficiencies. It begins by introducing that vitamin deficiencies often occur alongside general malnutrition in developing countries and can affect certain groups in developed countries. Vitamins are classified as either fat-soluble (A, D, E, K) or water-soluble (C, B complex). The rest of the document details specific vitamin deficiencies, symptoms of deficiencies, recommended daily intake of each vitamin, and the functions of each in the body. Deficiencies of vitamins A, C, D, E, K, B1, B2, B3, B5, B6, B9, and B12 are all discussed in turn.
Vitamins are organic compounds that are required in small amounts for various metabolic functions and play important roles in regulating metabolism, growth, and reproduction. They are classified as either water-soluble or fat-soluble based on their solubility properties. Water-soluble vitamins dissolve in water and are not stored in the body, while fat-soluble vitamins are absorbed with fats and can accumulate in tissues. Vitamins must be obtained from foods as the body cannot synthesize them in sufficient amounts. Deficiencies can lead to various diseases depending on the vitamin.
Vitamins are essential organic substances needed by the body in small amounts to perform specific metabolic functions. There are 13 legitimate vitamins that exist as either fat-soluble (A, D, E, K) or water-soluble (C, B-complex). Fat-soluble vitamins are stored in tissues while water-soluble vitamins are not stored and require consistent dietary intake. Deficiencies of vitamins can result in diseases like rickets, osteomalacia, beriberi, and pellagra depending on the specific vitamin lacking in the diet.
Vitamins UNIT-7 biochemistry and clinical pathology, D.Pharm 2nd year.pptxAanchal Gupta
Vitamins, unit-7 for D.Pharm second year, According to PCI syllabus.
Definition and classification with examples
Sources, chemical nature, functions, coenzyme form, recommended dietary requirements, deficiency diseases of fat-and water-soluble vitamins
Contents:
Vitamins: Definition
Classification of vitamins.
Fat soluble vitamins: Vitamin A, Vitamin D, Vitamin E and Vitamin K. Chemical nature, Dietary sources, Coenzyme forms, Biochemical functions, recommended dietary allowances and deficiency diseases of fat soluble vitamins.
This document provides information about Akash Mahadev Iyer, who is an S2 M.Sc Biochemistry student at the University of Kerala in Kariyavattom. It then discusses vitamins in general and provides details on the 13 essential vitamins for humans, including fat-soluble vitamins A, D, E, and K, and water-soluble B complex vitamins and vitamin C. For each vitamin, the document outlines their chemical structure, food sources, functions in the body, deficiency and toxicity symptoms, and recommended dietary allowances.
Vitamins and minerals are essential nutrients that humans must obtain through their diet. There are two classes of vitamins - fat soluble (A, D, E, K) and water soluble. Fat soluble vitamins are absorbed with fat and can accumulate in the body, while water soluble vitamins are not readily stored. Vitamins function as coenzymes and precursors for important metabolic processes. Deficiencies can lead to diseases like rickets, osteomalacia and night blindness. Common dietary sources of vitamins and requirements are also discussed.
Vitamin A exists in several forms including retinol, retinal, and retinoic acid. It is fat soluble and derived from carotenoids in plants like beta-carotene which the body converts. Vitamin A supports vision, cell growth, epithelial integrity, and acts as an antioxidant. It plays a key role in rhodopsin which is needed for vision in dim light. Deficiency can cause night blindness and keratinization while excess intake can be toxic, causing bone pain and liver issues.
This document discusses vitamins A and E. It defines vitamins and classifies them as fat-soluble or water-soluble. For vitamin A, it describes the different forms, absorption, transport and storage in the body, and functions including vision, gene expression, cell growth and differentiation. Deficiency causes night blindness and can lead to blindness. Vitamin E is an antioxidant that protects cells and prevents sterility.
Vitamins are organic compounds required in small amounts for normal growth, health and biological functions. They are classified as either fat-soluble (A, D, E, K) or water-soluble (C, B vitamins). Fat-soluble vitamins are absorbed with fats and stored in tissues while water-soluble vitamins are not stored and must be continuously supplied. Each vitamin plays important roles as enzyme cofactors in critical biochemical reactions related to energy production, cell growth, immune function and more. The document provides details on the chemistry, sources, functions and requirements of several key vitamins.
This document discusses the fat-soluble vitamins A, D, E, and K. It provides details on their sources, absorption, functions, deficiencies, and toxicity. The key points are:
1) Fat-soluble vitamins are stored in tissues and excess intake can be harmful unlike water-soluble vitamins.
2) Vitamin A supports vision, immune function, and cell growth. Too much can cause birth defects and liver damage.
3) Vitamin D aids calcium absorption and bone formation. The body produces it from sunlight but it is also found in foods. Deficiency causes rickets and osteomalacia.
4) Vitamin E is an antioxidant that protects cells. Def
This document provides information about Vitamin A, including its key features, functions, deficiency, toxicity, and sources. It discusses how Vitamin A is necessary for vision, gene transcription, immune function, embryonic development, and other processes. Deficiency can cause night blindness and keratomalacia, while toxicity may result in headaches, vomiting, and other issues. Good sources include liver, egg yolks, dairy products, carrots, and other orange and dark green vegetables.
Vitamins are organic compounds that are required in small amounts for various biochemical functions. Vitamin A plays important roles in vision, gene regulation, growth, and differentiation. It exists in multiple forms including retinol, retinal, and retinoic acid. Deficiency can result in night blindness, dry eyes, corneal ulcers and blindness. Vitamin D is important for calcium absorption and bone health. It is synthesized from cholesterol in the skin upon sun exposure or obtained from dietary sources.
Shubham Sharma presented on vitamins A, C, and E. The presentation covered the chemistry, classification, physiological significance, deficiencies, and daily requirements of each vitamin. Vitamin A is fat-soluble and important for vision, immune function, and growth. Vitamin C is water-soluble and essential for collagen formation and acting as an antioxidant. Vitamin E is a fat-soluble antioxidant that protects cell membranes and prevents lipid peroxidation.
This document provides an overview of fat-soluble vitamins, including Vitamins A, D, E, and K. It discusses the general characteristics, functions, classification, and individual details of each vitamin. For each vitamin, the document outlines its dietary sources, mechanisms of action in the body, functions, and deficiency diseases. The presentation aims to introduce the key properties and roles of the important fat-soluble vitamins.
This document discusses vitamin D in animals. It covers the chemical structure of vitamin D, how it is metabolized in the body through conversion in the liver and kidneys, its functions related to calcium and phosphorus homeostasis, and its roles in the intestines, bones and kidneys. The document also addresses requirements, natural sources, signs of deficiency such as rickets, and supplementation and toxicity concerns.
This document discusses vitamins, specifically vitamin D. It defines vitamins and describes the classification of fat-soluble and water-soluble vitamins. The document focuses on vitamin D, describing its sources, metabolism, functions, recommended dietary allowance, and disorders related to deficiencies or excess, including rickets. Rickets is discussed in detail, outlining its morphology, etiology, clinical features involving the head, chest, back, extremities, and hypocalcemic symptoms. Oral manifestations of rickets involving dentition, bone, and soft tissue are also summarized.
SAMPLING TECHNIQUES AND HOW TO SELECT.pptxDanchadi
The document discusses various sampling techniques used in research including probability sampling methods like simple random sampling, systematic sampling, stratified sampling, cluster sampling, and multistage sampling as well as non-probability sampling methods such as snowball sampling, convenience sampling, purposive sampling, quota sampling, and self-selection sampling. It provides details on how each method works and lists their advantages and disadvantages.
A vitamin is an organic compound and a vital nutrient that an organism requires in limited amounts. An organic chemical compound (or related set of compounds) is called a vitamin when the organism cannot synthesize the compound in sufficient quantities, and it must be obtained through the diet; thus, the term "vitamin" is conditional upon the circumstances and the particular organism.
This document discusses disorders related to vitamin deficiencies. It begins by introducing that vitamin deficiencies often occur alongside general malnutrition in developing countries and can affect certain groups in developed countries. Vitamins are classified as either fat-soluble (A, D, E, K) or water-soluble (C, B complex). The rest of the document details specific vitamin deficiencies, symptoms of deficiencies, recommended daily intake of each vitamin, and the functions of each in the body. Deficiencies of vitamins A, C, D, E, K, B1, B2, B3, B5, B6, B9, and B12 are all discussed in turn.
Vitamins are organic compounds that are required in small amounts for various metabolic functions and play important roles in regulating metabolism, growth, and reproduction. They are classified as either water-soluble or fat-soluble based on their solubility properties. Water-soluble vitamins dissolve in water and are not stored in the body, while fat-soluble vitamins are absorbed with fats and can accumulate in tissues. Vitamins must be obtained from foods as the body cannot synthesize them in sufficient amounts. Deficiencies can lead to various diseases depending on the vitamin.
Vitamins are essential organic substances needed by the body in small amounts to perform specific metabolic functions. There are 13 legitimate vitamins that exist as either fat-soluble (A, D, E, K) or water-soluble (C, B-complex). Fat-soluble vitamins are stored in tissues while water-soluble vitamins are not stored and require consistent dietary intake. Deficiencies of vitamins can result in diseases like rickets, osteomalacia, beriberi, and pellagra depending on the specific vitamin lacking in the diet.
Vitamins UNIT-7 biochemistry and clinical pathology, D.Pharm 2nd year.pptxAanchal Gupta
Vitamins, unit-7 for D.Pharm second year, According to PCI syllabus.
Definition and classification with examples
Sources, chemical nature, functions, coenzyme form, recommended dietary requirements, deficiency diseases of fat-and water-soluble vitamins
Contents:
Vitamins: Definition
Classification of vitamins.
Fat soluble vitamins: Vitamin A, Vitamin D, Vitamin E and Vitamin K. Chemical nature, Dietary sources, Coenzyme forms, Biochemical functions, recommended dietary allowances and deficiency diseases of fat soluble vitamins.
This document provides information about Akash Mahadev Iyer, who is an S2 M.Sc Biochemistry student at the University of Kerala in Kariyavattom. It then discusses vitamins in general and provides details on the 13 essential vitamins for humans, including fat-soluble vitamins A, D, E, and K, and water-soluble B complex vitamins and vitamin C. For each vitamin, the document outlines their chemical structure, food sources, functions in the body, deficiency and toxicity symptoms, and recommended dietary allowances.
Vitamins and minerals are essential nutrients that humans must obtain through their diet. There are two classes of vitamins - fat soluble (A, D, E, K) and water soluble. Fat soluble vitamins are absorbed with fat and can accumulate in the body, while water soluble vitamins are not readily stored. Vitamins function as coenzymes and precursors for important metabolic processes. Deficiencies can lead to diseases like rickets, osteomalacia and night blindness. Common dietary sources of vitamins and requirements are also discussed.
Vitamin A exists in several forms including retinol, retinal, and retinoic acid. It is fat soluble and derived from carotenoids in plants like beta-carotene which the body converts. Vitamin A supports vision, cell growth, epithelial integrity, and acts as an antioxidant. It plays a key role in rhodopsin which is needed for vision in dim light. Deficiency can cause night blindness and keratinization while excess intake can be toxic, causing bone pain and liver issues.
This document discusses vitamins A and E. It defines vitamins and classifies them as fat-soluble or water-soluble. For vitamin A, it describes the different forms, absorption, transport and storage in the body, and functions including vision, gene expression, cell growth and differentiation. Deficiency causes night blindness and can lead to blindness. Vitamin E is an antioxidant that protects cells and prevents sterility.
Vitamins are organic compounds required in small amounts for normal growth, health and biological functions. They are classified as either fat-soluble (A, D, E, K) or water-soluble (C, B vitamins). Fat-soluble vitamins are absorbed with fats and stored in tissues while water-soluble vitamins are not stored and must be continuously supplied. Each vitamin plays important roles as enzyme cofactors in critical biochemical reactions related to energy production, cell growth, immune function and more. The document provides details on the chemistry, sources, functions and requirements of several key vitamins.
This document discusses the fat-soluble vitamins A, D, E, and K. It provides details on their sources, absorption, functions, deficiencies, and toxicity. The key points are:
1) Fat-soluble vitamins are stored in tissues and excess intake can be harmful unlike water-soluble vitamins.
2) Vitamin A supports vision, immune function, and cell growth. Too much can cause birth defects and liver damage.
3) Vitamin D aids calcium absorption and bone formation. The body produces it from sunlight but it is also found in foods. Deficiency causes rickets and osteomalacia.
4) Vitamin E is an antioxidant that protects cells. Def
This document provides information about Vitamin A, including its key features, functions, deficiency, toxicity, and sources. It discusses how Vitamin A is necessary for vision, gene transcription, immune function, embryonic development, and other processes. Deficiency can cause night blindness and keratomalacia, while toxicity may result in headaches, vomiting, and other issues. Good sources include liver, egg yolks, dairy products, carrots, and other orange and dark green vegetables.
Vitamins are organic compounds that are required in small amounts for various biochemical functions. Vitamin A plays important roles in vision, gene regulation, growth, and differentiation. It exists in multiple forms including retinol, retinal, and retinoic acid. Deficiency can result in night blindness, dry eyes, corneal ulcers and blindness. Vitamin D is important for calcium absorption and bone health. It is synthesized from cholesterol in the skin upon sun exposure or obtained from dietary sources.
Shubham Sharma presented on vitamins A, C, and E. The presentation covered the chemistry, classification, physiological significance, deficiencies, and daily requirements of each vitamin. Vitamin A is fat-soluble and important for vision, immune function, and growth. Vitamin C is water-soluble and essential for collagen formation and acting as an antioxidant. Vitamin E is a fat-soluble antioxidant that protects cell membranes and prevents lipid peroxidation.
This document provides an overview of fat-soluble vitamins, including Vitamins A, D, E, and K. It discusses the general characteristics, functions, classification, and individual details of each vitamin. For each vitamin, the document outlines its dietary sources, mechanisms of action in the body, functions, and deficiency diseases. The presentation aims to introduce the key properties and roles of the important fat-soluble vitamins.
This document discusses vitamin D in animals. It covers the chemical structure of vitamin D, how it is metabolized in the body through conversion in the liver and kidneys, its functions related to calcium and phosphorus homeostasis, and its roles in the intestines, bones and kidneys. The document also addresses requirements, natural sources, signs of deficiency such as rickets, and supplementation and toxicity concerns.
This document discusses vitamins, specifically vitamin D. It defines vitamins and describes the classification of fat-soluble and water-soluble vitamins. The document focuses on vitamin D, describing its sources, metabolism, functions, recommended dietary allowance, and disorders related to deficiencies or excess, including rickets. Rickets is discussed in detail, outlining its morphology, etiology, clinical features involving the head, chest, back, extremities, and hypocalcemic symptoms. Oral manifestations of rickets involving dentition, bone, and soft tissue are also summarized.
SAMPLING TECHNIQUES AND HOW TO SELECT.pptxDanchadi
The document discusses various sampling techniques used in research including probability sampling methods like simple random sampling, systematic sampling, stratified sampling, cluster sampling, and multistage sampling as well as non-probability sampling methods such as snowball sampling, convenience sampling, purposive sampling, quota sampling, and self-selection sampling. It provides details on how each method works and lists their advantages and disadvantages.
Zinc plays multiple roles in the pancreas, skeletal muscle, and adipose tissue that determine its relationship to diabetes development. It is essential for insulin synthesis, storage, and secretion in pancreatic beta cells through numerous zinc transporter proteins. Zinc deficiency can impair glucose tolerance and increase type 2 diabetes risk by disrupting insulin signaling and glucose metabolism in these tissues. It also influences lipid metabolism and adipokine production in adipose tissue.
This document explores challenges in diagnosing febrile illnesses in tropical regions. It discusses how fever is a common symptom but determining the underlying cause can be difficult due to non-specific presentations. While malaria and typhoid were historically assumed causes, studies show rising incidence of other neglected tropical diseases. Diagnosis is limited by insufficient diagnostic tools and expertise in primary healthcare settings. The review aims to determine current etiologies, diagnostic limitations, and ways to improve diagnosis of febrile illnesses in the tropics through analyzing literature on frequencies, diagnostic techniques, and making recommendations.
This document discusses different types of observational studies, including cohort studies, case-control studies, and cross-sectional studies. Cohort studies follow groups of individuals over time to determine outcomes. Case-control studies compare individuals with a disease (cases) to those without (controls) to identify potential risk factors. Cross-sectional studies collect data on exposure and outcome at the same time to determine prevalence. While each study type has advantages and disadvantages, together they help identify disease risk factors and generate hypotheses for further research.
This document provides an overview of observational study designs, including definition, types, and examples. It discusses cohort studies, case-control studies, and cross-sectional studies. Cohort studies measure events over time to determine causes and prognosis. Case-control studies identify associations by comparing exposures in cases versus controls. Cross-sectional studies analyze a population at a single time point to determine prevalence. Observational studies are useful when randomization is not possible or ethical and can provide faster results than cohort studies.
Disorders of amino acid metabolism can occur due to deficiencies in enzymes involved in amino acid breakdown. Phenylketonuria results from a lack of phenylalanine hydroxylase, causing phenylalanine to build up. Maple syrup urine disease is caused by a deficiency in branched-chain keto acid dehydrogenase, leading to the accumulation of leucine, isoleucine, and valine. Albinism is a disorder of tyrosine metabolism due to absent or defective tyrosinase enzyme, resulting in a lack of melanin pigment in hair, skin, and eyes.
This document discusses various vitamins and coenzymes. It provides information on their structures, functions, deficiencies, sources, and metabolism. Key points include: vitamins are organic compounds essential for growth and development; deficiencies can cause diseases like beriberi, scurvy, and rickets; fat-soluble vitamins like A, D, E, and K require the liver and are toxic in high amounts; water-soluble vitamins include the B complex vitamins and vitamin C; and vitamins act as coenzymes and regulators of various metabolic processes.
Single nucleotide polymorphisms (SNPs) are the most common genetic variation among humans, representing differences in single DNA nucleotides between individuals. SNPs occur approximately every 1000-300 bases and can be found in both coding and non-coding regions. The majority of SNPs are harmless, but some can cause changes in phenotypes or increase risk of diseases. Researchers use SNPs for applications like personalized medicine, tracking inheritance of disease genes, and determining genotype-phenotype relationships.
This document discusses laboratory management, inventory control, ordering, and budgeting. It covers key aspects of lab management including leadership, planning, and communication. Inventory management involves processes for replenishing supplies and forecasting needs to avoid stock-outs or excess inventory. Inventory control ensures the right amount and type of supplies are in the right place. Developing and monitoring a budget aids in planning, coordination, communication, control and evaluation of lab activities and performance. Challenges can include rigid decision-making, time required, and blame for budget outcomes.
This document provides guidelines for the proper collection, transportation, preparation, processing, and storage of laboratory samples for disease diagnosis and monitoring. It discusses defining samples and specimens, examples of laboratory samples, requirements for sample collection, potential errors from improper collection, and objectives of collection. Specific guidance is given for collection and handling of various sample types, including blood, urine, cerebrospinal fluid, stool, and others. Proper labeling, transport, separation, preservation, and storage methods are also outlined to ensure sample quality and integrity.
Computer in pharmaceutical research and development-Mpharm(Pharmaceutics)MuskanShingari
Statistics- Statistics is the science of collecting, organizing, presenting, analyzing and interpreting numerical data to assist in making more effective decisions.
A statistics is a measure which is used to estimate the population parameter
Parameters-It is used to describe the properties of an entire population.
Examples-Measures of central tendency Dispersion, Variance, Standard Deviation (SD), Absolute Error, Mean Absolute Error (MAE), Eigen Value
“Psychiatry and the Humanities”: An Innovative Course at the University of Mo...Université de Montréal
“Psychiatry and the Humanities”: An Innovative Course at the University of Montreal Expanding the medical model to embrace the humanities. Link: https://www.psychiatrictimes.com/view/-psychiatry-and-the-humanities-an-innovative-course-at-the-university-of-montreal
Spontaneous Bacterial Peritonitis - Pathogenesis , Clinical Features & Manage...Jim Jacob Roy
In this presentation , SBP ( spontaneous bacterial peritonitis ) , which is a common complication in patients with cirrhosis and ascites is described in detail.
The reference for this presentation is Sleisenger and Fordtran's Gastrointestinal and Liver Disease Textbook ( 11th edition ).
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Giloy in Ayurveda - Classical Categorization and SynonymsPlanet Ayurveda
Giloy, also known as Guduchi or Amrita in classical Ayurvedic texts, is a revered herb renowned for its myriad health benefits. It is categorized as a Rasayana, meaning it has rejuvenating properties that enhance vitality and longevity. Giloy is celebrated for its ability to boost the immune system, detoxify the body, and promote overall wellness. Its anti-inflammatory, antipyretic, and antioxidant properties make it a staple in managing conditions like fever, diabetes, and stress. The versatility and efficacy of Giloy in supporting health naturally highlight its importance in Ayurveda. At Planet Ayurveda, we provide a comprehensive range of health services and 100% herbal supplements that harness the power of natural ingredients like Giloy. Our products are globally available and affordable, ensuring that everyone can benefit from the ancient wisdom of Ayurveda. If you or your loved ones are dealing with health issues, contact Planet Ayurveda at 01725214040 to book an online video consultation with our professional doctors. Let us help you achieve optimal health and wellness naturally.
5-hydroxytryptamine or 5-HT or Serotonin is a neurotransmitter that serves a range of roles in the human body. It is sometimes referred to as the happy chemical since it promotes overall well-being and happiness.
It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
2. Polish biochemist Casimir Funk discovered vitamin B1
in 1912 in rice bran.
He proposed the complex be named "Vitamin" (vital
amines).
By the time it was shown that not all vitamins were
amines, the word was already ubiquitous.
3. Vitamin - definition
An organic compound required as a nutrient in tiny
amounts by an organisms.
It cannot be synthesized in sufficient quantities by an
organism, and must be obtained from the diet.
Vitamins have diverse biological function:
hormone-like functions as regulators of mineral metabolism (vit.
D),
regulators of cell and tissue growth and differentiation (some
forms of vit. A)
antioxidants (vit. E, C)
enzyme cofactors (tightly bound to enzyme as a part of
prosthetic group, coenzymes)
4. Vitamin classification
Lipid-soluble vitamins (A, D, E and K)
hydrophobic compounds, absorbed efficiently with
lipids,
transport in the blood in lipoproteins or attached to
specific binding proteins,
more likely to accumulate in the body,
more likely to lead to hypervitaminosis
5. Vitamin classification
Water-soluble vitamins - 8 B vitamins and vitamin C
Function: mainly as enzyme cofactors,
hydrophilic compounds dissolve easily in water,
not readily stored, excreted from the body,
their consistent daily intake is important.
Many types of water-soluble vitamins are synthesized
by bacteria.
6. Lipid-soluble vitamins
Vitamin A
Retinol
Biologically active forms -
retinoids: retinol, retinal,
retinoid acid.
Major vit. A precursors
(provitamins) → plants
carotenoids.
Foodstaf of animals origin
contain most of vit. A in the
form of esters (retinylpalmi-
tates) – retinol and long fatty
acid
Cyklohexan ring and isoprenoid
chain
7. Retonol esters → hydrolysis by
pancreatic enzymes to retinol.
b-caroten is cleaved to retinal by b-
carotene 15,15´ dioxygenase
(cofactors iron and bile salts).
Intestinal cells → esterification of
retinol → transported in
chylomicrons.
Remnants of chylomicrons →
liver→ esterification (if the
concentration exceeds 100 mg,
esters are stored ).
Transport of retinol to target
organs tightly bound to retinol-
binding protein, RBP.
Vit. A transport and metabolism
8. Vitamin A and vision
Vit. A is necessary to form rhodopsin
(in rodes, night vision) and iodopsins
(photopsins, in cones – color vision) -
visual pigment.
Retinaldehyd is a prosthetic group of
light-sensitive opsin protein.
In the retina, all-trans-retinol is
isomerized to 11-cis-retinol → oxidized
to 11-cis-retinaldehyd, this reacts with
opsin (Lys) → to form the holoprotein
rhodopsin.
Absorption of light → conformation
changes of opsin → photorhodopsin.
9. Vitamin A and vision
The following is a series of
izomerisation→ initiation of
nerve impulse.
The final step is hydrolysis to
release all-trans-retinaldehyde
and opsin.
Deficiency of vit. A leads to
night blindness.
Vitamin A is an important
antioxidant.
10. Vitamin A and other functions
Transcription and cell differentiation
Retinoic acid regulates the transcription of genes - acts through nuclear
receptors (steroid-like receptors).
By binding to various nuclear receptors, vit. A stimulates (RAR – retinoid
acid receptor) or inhibits (RXR- retinoid „X“ receptor) transcription of genes
transcription. All-trans-retinoic acid binds to RAR and 9-cis-retinoic acid
binds to RXR.
Retinoic acid is necessary for the function and maintenance of epithelial
tissues.
Retinol retinal retinoic acid
Retinol dehydrogease Retinaldehyde dehydrogenasa
11. Vitamin A - deficiency
The early sign → a loss of sensitivity to green light,
prolonged deficiency → impairment to adapt to dim light
more prolonged deficiency leads to night blindness
Ever escalated deficiency leads to squamous metaplasia -
columnar epithelia are transformed into heavily keratinized
squamous epithelia.
The conjunctiva loses mucus-secreting cells → glykoprotein
content of the tears is reduced → xeroftalmia ( „dry eyes“)
Often complication - bacterial or chlamidial infection which results
in perforation of the cornea and blindness
12. Vitamin A - deficiency
Transformation of respiratory epithelium – loss of protective
airway function (antibacterial properties) → bronchitis.
Conversion of the urinary tract epithelium → higher frequency
of urinary stone formation
Immunosuppression
Impairment of reproductive function (both in men and women).
Worldwide deficiency of vit. A
3 – 10 mil. children become xerophtalmic every year
250 000 to 500 000 go to blindness
1 million die from infections
13. Vitamin A - toxicity
Toxic dose:
single dose of more than 200 mg
more than 40 mg per day
Acute symptoms - headache, vomiting, impaired consciousness.
Chronic intoxication – weight loss, vomiting, pain in joints,
muscles, blurred vision, hair loss, excessive bone growth.
Both vit. A excess and deficiency in pregnancy are teratogenic –
retinoic acid is gene regulator during early fetal development
Carotenoids are non toxic - accumulation in tissues rich in lipids
(the skin of babies overdosed with carrot juice may be orange).
14. Metabolic functions of vitamin A
Vision
Gene transcription
Immune function
Embryonic development and reproduction
Bone metabolism
Haematopoieis
Skin health
Antioxidant activity
16. Vitamin D
Calciol, vitamin D2 (cholecalciferol) → precursor of
calcitriol, D3 (1,25-dihydroxycalciferol).
Regulates with PTH calcium and phosphate level
(absorption, reabsorption, excretion).
Synthesis in the skin (7-dehydrocholesterol) UV →
further transformation in the liver and kidneys .
19. Effects of vitamin D
Transported in the blood on a carrier (vitamin-D binding
protein, VDBP).
1,25(OH)2D binds to intracellular receptors (intestine, bone,
kidney).
The main function is to maintain plasma levels of calcium
(essential for neuromuscular activity) and phosphate levels:
increase Ca absorption in the intestine,
reduce the excretion of calcium (stimulates parathyroid hormone-
dependent Ca reabsorption in the distal tubule),
mobilizing bone mineral, together with parathyroid hormone
20. Vitamin D - deficincy
Failure of absorption in the intestine.
The lack of the liver and the renal hydroxylation of
vit. D (congenital deficiency of 1-hydroxylase).
The lack of UV irradiation.
The main manifestation - impaired ossification of the
newly created osteiod, abundance of non mineralized
matrix.
Vit. D is necessary for the prevention of skeletal
changes (rickets in growing individuals, osteomalacia
in adults).
21. Vitamin D and imunity
It increases the activity of natural killer cells
(cytotoxic lymphocytes).
Increases the phagocytic ability of macrophages .
Reduces the risk of virus diseases (colds, flu).
Reduces the risk of many cancers (colon, breast and
ovarian cancer).
Reduces the risk of cardiovascular disease → have a
positive impact on the composition of plasma lipids.
22. Sources of vitamin D
In addition to sunbathing:
various fish species (salmon,
sardines and mackerel, tuna,
catfish, eel), fish oil, cod liver
eggs, beef liver, mushrooms
23. Vitamin E
Vitamin E is a family of a-, b-, g-, d- tocopherols and
corresponding tocotrienols isomers.
They are formed from chromatin ring and hydrofobic
side chain.
The highest biological activity has a-tocopherol.
24. Vitamin E
Adsorbtion from the small intestine.
Its absorption is dependent on the presence of lipids
in the diet.
Associated with plasma lipoproteins → liver uptake
through receptors for apolipoprotein E.
a-tocopherol is bind to a-tocopherol transport
protein (a-TTP) → transported to the target organs
(the excess is stored in adipocytes, in muscle, liver).
b-, g- a d-tocopherols are transferred into the bile
and degraded.
25. Vitamin E as antioxidant
Stops free radical reactions (peroxyl radicals ROO , oxygen radicals
HO, lipoperoxid radicals LOO). Chroman ring with OH group → uptake
radicals.
26. PUFA-H = polyunsaturated fatty acid
PUFA-OO = peroxyl radical of polyunsaturated
fatty acid
PUFA-OOH = hydroxyperoxy polyunsaturated
fatty acid
PUFA-OH = hydroxy polyunsaturated fatty acid
Free radical
chain reaction
Interaction and synergism between
antioxidant systems operating in the
lipid phase (membranes) and the
aqueous phase (cytosol)
27. Vitamin E as enzyme cofactor
a-tocopherol quinon generated by oxidation of a-
tocopherol can acts as a cofactor of mitochondrial
unsaturated fatty acids .
a-tocopherol quinon + cytochrom B5 + NADH+H+
initiate formation of double bonds in FA – temporarily
changes to a-tocopherol-hydroquinon (in the
presence of O2 changes back to a-tocopherol
quinon).
28. Vitamin E – deficiency and toxicity
The lack of a-tocopherol in plasma is often
associated with impaired fat absorption or
distribution (in patients with cystic fibrosis, in
patients with intestine resection)
deficit of vit. D exhibit - neurological problems,
impaired vision, eye muscle paralysis, platelet
aggregation, impairment of fertility in men, impaired
immunity.
Toxicity is relatively small.
29. Sources of vitamin E
fortified cereals
seeds and seed oils, like sunflower
nuts and nut oils, like almonds and hazelnuts
green leafy vegetables,
broccoli
cabbage
celery
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30. Vitamin K
Vitamin K is a group of lipophilic, hydrophobic
vitamins.
They are needed for the postranslation modification
of proteins required for blood coagulation,
They are involved in metabolism pathways, in bone
mineralisation, cell growth, metabolism of blood
vessel wall.
31. Vitamin K1
Vitamin K2
Vitamin K
Vitamin K1 (phylloquinon) – plant
origin
Vitamin K2 (menaquinon) –
normally produced by bacteria in
the large intestine
K1 a K2 are used differently in the
body
K1 – used mainly for blood
clothing
K2 – important in non-coagulation
actions - as in metabolism and
bone mineralization, in cell
growth, metabolism of blood
vessel walls cells.
Synthetic derivatives of Vit.K
32. Vitamin K - function
Cofactor of liver microsomal carboxylase which
carboxylates glutamate residues to g-
carboxyglutamate during synthesis of prothrombin
and coagulation factors VII, IX a X (posttranslation
reaction).
Carboxylated glutamate chelates Ca2+ ions,
permitting the binding of blood clotting proteins to
membranes.
Forms the binding site for Ca2+ also in other proteins
– osteocalcin.
33. Vitamin K - deficiency
Deficiency is caused by fat malabsorption or by the
liver failure.
Blood clotting disorders – dangerous in newborns,
life-threatening bleeding (hemorrhagic disease of the
newborn).
Osteoporosis due to failed carboxylation of
osteokalcin and decreased activity of osteoblasts.
Under normal circumstances there is not a shortage,
vit. K is abundant in the diet.
34. Sources of vitamin K
Green leafy vegetables
vegetable oil
broccoli
cereals
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35. Vitamin B1 (thiamine)
Vitamin B2 (riboflavin)
Vitamin B3 or Vitamin P or Vitamin PP (niacin)
Vitamin B5 (panthotenic acid)
Vitamin B6 (pyridoxine and pyridoxamine)
Vitamin B7 or Vitamin H (biotin)
Vitamin B9 or Vitamin M and Vitamin B-c (folic acid)
Vitamin B12 (cobalamin)
Water soluble vitamins
36. Vitamin B1 (thiamine)
Thiamin has a central role in energy-yielding
metabolism.
Composed of a substituted pyridine and thiazole ring.
Active form is thiamine diphosphate (thiamin
pyrophosphate, TPP), a coenzyme for three multi-
enzyme complex →
This complex catalyses oxidative decarboxylation of
a-ketoacids →
pyruvate dehydrogenase in carbohydrate metabolism,
a-ketoglutarate dehydrogenase → cytric acid cycle,
Branched-chain keto-acid dehydrogenase .
TPP is coenzyme for transketolase – pentose phosphate
pathway.
37. Vitamin B1 - deficiency
1. Mild deficiency – leads to gastrointestinal complients,
weakness
2. Moderate deficiency - peripheral neuropathy, mental
abnormalities, ataxia
3. Full-blown deficiency - beri-beri – characterized with
severe muscle weakness, muscle wasting and
delirium, paresis of the eye muscles, memory loss.
Degeneration of the cardiovascular system. .
Beri-beri causes long-term consumption of foods rich
in carbohydrates but poor in thiamine - husked rice,
white flour and refined sugar.
39. Vitamin B2 (riboflavin)
Yellow to orange-yellow natural dye slightly soluble in
water.
Has a central role in energy-yielding metabolism.
Provides the reactive moieties of the coenzymes
flavin mononucleotide (FMN) and flavin adenine
dinucleotid (FAD).
Flavin coenzymes are electron carries in
oxidoreduction reaction.
40. Vitamin B2
FMN → ATP-dependent phosphorylation of riboflavin
FAD → further reaction with ATP in which its AMP
moiety is transferred to FMN.
41. FMN a FAD function
FMN and FAD act as prosthetic groups of many oxidoreduction
enzymes, flavoprotein:
oxydase of a-amino acids – degradation of amino acids
xantinoxidase – degradation of purines
aldehyde dehydrogenas
mitochondrial glycerol-3-phosphate dehydrogenase – transport
of reducing unit (H+) from mitochondra to cytosol
succinate dehydrogenas – citric acid cycle
succinyl CoA-dehydrogenase – b-oxidation of FA
NADH-dehydrogenase – part of respiratory chain in
mitochondria
coenzymes in hydrogen transfer – formation of reducing forms -
FMNH2 a FADH2
42. Vitamin B2 absorption
Riboflavin is absorbed in the proximal intestine.
Riboflavin is stored mainly in the liver, kidney and
heart in the form of FAD (70- 90%) or FMN.
43. Causes of vitamin B2 deficiency
Lack of dietary vitamin B.
A result of conditions that affect absorption in the
intestine.
The body not being able to use the vitamin.
An increase in the excretion of the vitamin from the
body.
44. Vitamin B2 – symptoms of deficiency
Cracked and red lips.
Inflammation of the lining of mouth and tongue.
Dry and scaling skin- keratitis, dermatitis and iron-
deficiency anemia
45. Sources of vitamin B2
foods of animal origin
(liver, pork and beef, milk,
dairy products, fish eggs)
cocoa,
nuts,
yeast,
of smaller quantities in
cereals.
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46. Vitamin B3 - niacin
Active form – nikotinic acid and nikotinamid.
NAD a NADP → key components of the metabolic pathways of
carbohydrates, lipids, amino acids.
Nicotinic acid prevents the release of fatty acids from adipose
tissue, decreases lipoproteins VLDL, IDL a LDL.
High dose of niacin dilates blood vessels .
47. Vitamin B3 - niacin
Absorption:
At low concentration by active transport.
At high concentration by passive diffusion.
Transportation:
Both nicotinic acid (NA) and nicotinamide (NAm) bind to
plasma proteins for transportation.
Biosynthesis:
The liver can synthesize Niacin from the essential amino acid
tryptophan, but the synthesis is extremely slow and
requires vitamin B6 (60 mg of Tryptophan= 1mg of niacin).
Bacteria in the gut may also perform the conversion but are
inefficient.
48. Vitamin B3 - deficiency
Pellagra: A serious deficiency of niacin.
The main results of pellagra can easily be
remembered as "the four D's": diarrhea, dermatitis,
dementia, and death.
Pelagra is very rare now, except in alcoholics, strict
vegetarians, and people in areas of the world with
very poor nutrition.
Milder deficiencies of niacin can cause dermatitis
around the mouth and rashes, fatigue, irritability,
poor appetite, indigestion, diarrhea, headache.
49. Sources of vitamin B3
foods of animal origin
yeast
sunflower seeds, beans, peas
green leafy vegetable
broccoli, carrots
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50. Vitamin B5 – panthotenic acid
Part of acetyl-CoA – consists of pantoic acid and
b-alaninem.
51. Vitamin B5 – panthotenic acid
Co-enzyme A assists the following reactions:
formation of sterols (cholesterol and 7-
dehydrocholesterol).
formation of fatty acids.
formation of keto acids such as pyruvic acid.
Other reactions are acylation, acetylation, signal
transduction deamination
52. Vitamin B5 - deficiency
Rare to occur.
When occur it leads to paresthesias.
Disorders of the synthesis of acetylcholine –
neurological symptoms (parestesie).
53. Sources of vitamin B5
meat, foods of animal origin,
yeast,
wholemeal bread,
broccoli, avocado
royal gelly
55. Vitamin B6
Vitamin B6 is needed for more than 100 enzymes involved in
protein metabolism.
It is also essential for red blood cell metabolism and
hemoglobin formation.
The nervous and immune systems need vitamin B6 to
function efficiently.
It is also needed for the conversion of tryptophan to niacin
(vitamin B3).
Vitamin B6 also helps maintain blood glucose within a normal
range. When caloric intake is low, vitamin B6 helps to convert
stored carbohydrate or other nutrients to glucose to maintain
normal blood sugar levels.
57. Vitamin B6 deficiency
Signs of vitamin B6 deficiency include:
Skin: dermatitis (skin inflammation), stomatitis
(inflammation of the mucous lining of any of the
structures in the mouth), glossitis (inflammation or
infection of the tongue ).
Neurological abnormalities: Depression, confusion,
and convulsions.
Vitamin B6 deficiency also can cause anemia.
58. Vitamin B6 – narural sources
cereals,
beans,
meat,
liver,
fish,
yeast,
nuts and some fruits as banana
potatoes.
It is also produced by bacterial
flora in the colon.
59. Vitamin B7 - biotin
Prosthetic group of pyruvate carboxylase,
acetyl-CoA carboxylase and other ATP-
dependent carboxylases.
62. Vitamin B9 – folic acid
Active metabolit of folic acid is tetrahydrofolate (THF) .
THF is coenzym of transferases carrying one carbon units.
This reaction participate in nucleotide and nucleic acid synthesis
N5,N10-THF carries one carbon units (methylen or methenyl).
63. Folic acid deficiency
Deficiency results in elevated levels of homocystein.
Deficiency in pregnant women can lead to birth defects.
64. Sources of vitamin B9
sources of animal origin
milk and milk products
yeast
greens
65. Vitamin B12 - cobalamin
Chemically most complex
vitamin
Complex of organic
compounds atom within the
molecule is Co, similar to the
heme.
In man there are two
metabolically active forms:
methylkobalamin a
adenosylkobalamin.
66. Vitamin B12 - cobalamin
Cobalamin catalyses two reactions
Cytoplasmic methylation of homocystein to
methionin.
Mitochondrial methylmalonyl-CoA mutase
(methylmalonyl-CoA → sukcynyl-CoA) needs
deoxy adenosylkobalamin.
67. Vitamin B12 – cobalamin
Essential for the maturation of erythrocytes.
Protects against pernicious anemia.
Essential for cell growth and reproduction.
Essential for the formation of myelin and
nucleoproteins.
68. Vitamin B12 – cobalamin
Vitamin B12 in food is bound to the protein.
Hydrochloric acid in the stomach releases free
vitamin B12.
Once released vitamin B12 combines with a substance
called intrinsic factor (IF). This complex can then be
absorbed by the intestinal tract.
69. Sources of vitamin B12
fish and shellfish,
meat (especially liver),
poultry,
eggs,
milk, and
milk products
while lacto-ovo vegetarians usually get enough B12
through consuming diary products, vegan will lack
B12
70. Vitamin C
Vitamin C is a water-soluble vitamin.
Almost all animals and plants synthesize their own
vitamin C, not man.
Vitamin C was first isolated in 1928 and in 1932 it
was proved to be the agent which prevents scurvy.
71. Vitamin C
Vitamin C is a weak acid, called ascorbic acid or its
salts “ascorbates”.
It is the L-enantiomer of ascorbic acid.
The D-enantiomer shows no biological activity.
72. The role of vitaminC
Cofactor in the synthesis of norepinephrine from
dopamine.
Involved in a variety of metabolic processes
(oxidation-reduction reactions and cellular
respiration, carbohydrate metabolism, synthesis of
lipids and proteins).
antioxidant and free radical scavenger → maintain
proper immune system.
73. The role of vitaminC
T-lymphocyte activity, phagocyte function, leukocyte
mobility, and possibly antibody and interferon
production seem to be increased by vitamin C.
Involved in the synthesis of collagen, the major
component of ligaments, tendons, cartilages and
skin.
Involved in tyrosine metabolism.
74. Deficiency of vitaminC
Fatigue, personality changes, decline in psychomotor
performance and motivation.
Vitamin C deficiency over 3-5 months results in
symptomatic scurvy.
Scurvy leads to the formation of liver spots on the
skin, spongy gums, and bleeding from all mucous
membranes.
In advanced scurvy there are open, suppurating
wounds and loss of teeth. Severe scurvy may
progress to neuritis, jaundice, fever, dyspnea, and
death.