This document discusses genetic and acquired defects that can lead to dysregulated inflammation. It describes several genetic conditions that cause defects in leukocyte adhesion, phagolysosome function, and microbicidal activity. These defects predispose to recurrent bacterial infections. The document also outlines different morphological patterns inflammation can take, such as serous, fibrinous, purulent, and ulcerative. Examples are provided of disease states that demonstrate each pattern along with images showcasing the histopathological features.