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4.outcomes and morphology dr ashutosh kumar
This document discusses genetic and acquired defects that can lead to dysregulated inflammation. It describes several genetic conditions that cause defects in leukocyte adhesion, phagolysosome function, and microbicidal activity. These defects predispose to recurrent bacterial infections. The document also outlines different morphological patterns inflammation can take, such as serous, fibrinous, purulent, and ulcerative. Examples are provided of disease states that demonstrate each pattern along with images showcasing the histopathological features.
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4.outcomes and morphology dr ashutosh kumar
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- 2. DEFECTS IN LEUCOCYTEFUNCTION GENETIC • ADHESION DEFECTS- • LAD1, LAD2 • INTEGRINS AND SELECTIN RECEPTORS DEFECTIVE • REC BACTERIAL INFECTIONS AND IMPAIRED HEALING • DEFECTS IN PHAGOLYSOSOME FUNCTION • CHEDIAK HIGASHI SYN • AR • DEFECTIVE TRANSFER OF LYSOSOMAL ENZYMES
- 4. DEFECTS IN LEUCOCYTEFUNCTION • DEFECT IN MICROBICIDAL ACTIVITY • CGD-DEFECTS IN NADPH OXIDASE • REC BACTERIAL INFECTIONS • MPO DEF ACQUIRED-VARIOUS ASPECTS LIKE PHAGO,CHEMO ETC AFFECTED • DM • MALIGNANCY • MALNUTRITION • ANEMIA
- 6. Outcomes of acute inflammation
- 11. resolution • Restoration ofsite to normal • Usually occurs when 1. Limited or short lived 2. Little tissue destruction • Events
- 12. fibrosis • Connective tissuereplacement • Occurs in cases of 1. Extensive destruction 2. Tissues incapable of regeneration 3. Abundant fibrin exudation
- 13. suppuration • When causativeagent is pyogenic bacteria • Events
- 14. CHRONIC INFLAMMATION • Wheninflammation can not be resolved • In cases of 1. Persistence of agent 2. Interference with healing
- 15. MORPHOLOGICAL PATTERNS • SEROUS • THIN FLUID • Eg BLISTER OF BURN • FIBRINOUS • MORE SEV INJURY • FIBROGEN LEAKAGE CON TO FIBRIN • LINING OF BODY CAVITIES-MENINGES,PERICARDIUM • COR VILLOSUM/ BREAD AND BUTTER APP • MICRO-EOSINOPHILIC MESHWORK
- 16. MORPHOLOGICAL PATTERNS • SUPPURATIVE/PURULENT • SOME PYOGENIC BACTERIA • LARGE AMTS OF PUS • ABSCESS-LOCALIZED COLLECTION OF PUS WITHIN A CAVITY • ULCER • LOCAL DEFECT IN SKIN OR MUCOSA • Eg PEPTIC ULCER
- 17. SEROUS EXUDATE • BullousPemphigoid, • Serous Inflammation Dermis Blister fluid Serous Exudate
- 18. FIBRINOUS EXUDATE pericardial cavity showsfibrinous pericarditis with strands of stringy pale fibrin between visceral and parietal pericardium
- 19. FIBRINOUS INFLAMMATION Fibrinous exudate pericardium URAEMIC PERICARDITIS
- 20. PURULENT EXUDATE • Exuded yellowish fluid fluid in this opened pericardial cavity also contains a large number of acute inflammatory cells. So it is a purulent exudate
- 21. SUPPURATIVE INFLAMMATION A B A: purulent exudate obscuring the sulci in pyogenic meningitis. B: purulent peritonitis D/T rupture of the colon.
- 22. ABSCESS • rounded abscesses (the purulent material has drained out after sectioning to leave a cavity) in the lung.
- 23. ABSCESS • Diverticulitis of Colon with abscess formation Abscess Sulfur granules of actinomycoses Lots of neutrophils
- 24. ULCER Gross Gastroscopic View Microscopic view