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1. INFLAMMATION - OSPE
RAPID REVIEW
A N
By bbas aseem
abbas_naseem@yahoo.com

2. “ Education is a progressive
discovery of our own ignorance ”
Will Durant

3. First A look @
Slides from BIG ROBIN – 8th edition

4. Nature of leukocyte infiltrates in inflammatory reactions. The photomicrographs are representative
of the early (neutrophilic) (A) and later (mononuclear) cellular infiltrates (B) seen in an
inflammatory reaction in the myocardium following ischemic necrosis (infarction).

5. The characteristic histopathology of acute inflammation.
A, Normal lung shows thin (virtually invisible) blood vessels in the alveolar walls and no cells in the
alveoli.
B, The vascular component of acute inflammation is manifested by congested blood vessels (packed
with erythrocytes), resulting from stasis.
C, The cellular component of the response is manifested by large numbers of leukocytes (neutrophils)
in the alveoli.

6. Serous inflammation.
Low-power view of a cross-section of a skin blister showing the epidermis separated from the dermis
by a focal collection of serous effusion.

7. Fibrinous pericarditis.
A, Deposits of fibrin on the pericardium.
B, A pink meshwork of fibrin exudate (F) overlies the pericardial surface (P).

8. Purulent inflammation.
A, Multiple bacterial abscesses in the lung, in a case of bronchopneumonia.
B, The abscess contains neutrophils and cellular debris, and is surrounded by congested blood
vessels.

9. The morphology of an ulcer.
A, A chronic duodenal ulcer.
B, Low-power cross-section of a duodenal ulcer crater
with an acute inflammatory exudate in the base.

10. Chronic inflammation in the lung, showing all three characteristic histologic features:
(2) collection of chronic inflammatory cells (*),
(2) destruction of parenchyma (normal alveoli are replaced by spaces lined by cuboidal epithelium,
arrowheads),
and
replacement by connective tissue (fibrosis, arrows).
B, By contrast, in acute inflammation of the lung (acute bronchopneumonia)
, neutrophils fill the alveolar spaces and blood vessels are congested.

11. A focus of inflammation showing numerous eosinophils. (orange red/dark granules)

12. Typical tuberculous granuloma showing an area of central necrosis surrounded by multiple Langhans-
type giant cells, epithelioid cells, and lymphocytes.

13. Now ….
Exclusive Other Slides for OSPE Preparation
(including Slides from Robins Pathology)

14. Lymphocyte, neutrophil nd plasma cell

15. Monocyte

16. Eosinophil(orange red/dark granules), lymphocyte

17. Basophil(densely granular)

18. Eosinophil
neutrophil
Lymphocyte
Basophil
Monocyte

21. Neutrophil Margination
21

22. Vascular changes

23. Pneumonia - Exudation

24. Lymphocytes and macrophages

25. Macrophages in infarcted brain:

26. Plasma cells

27. Lymphocytes around a blood vessel:

28. Lymphoid follicles:

29. Granulomas seen in lung

30. Suppurative or purulent inflammation is
characterized by the production of large amounts
of pus or purulent exudate consisting of
neutrophils, necrotic cells, and edema fluid.

31. Serous inflammation is marked by the
outpouring of a thin fluid that, depending on
the size of injury, is derived from either the
plasma or the secretions of mesothelial cells
lining the peritoneal, pleural, and pericardial
cavities (called effusion).

32. FIBRINOUS INFLAMMATION
With more severe injuries and the resulting
greater vascular permeability, larger molecules
such as fibrinogen pass the vascular barrier, and
fibrin is formed and deposited in the
extracellular space

33. An ulcer is a local defect, or excavation, of the
surface of an organ or tissue that is produced by
the sloughing (shedding) of inflammatory
necrotic tissue

34. -------- eXclusive OSPE PICS --------
acute inflammation
The redness corresponds to the rubor of acute inflammation and calor (heat)
is due to histamine-dependent arteriolar vasodilatation.
Pain (dolor) in acute inflammation is due to bradykinin and PGE2

35. Leukocyte-margination and
pavementing

36. Neutrophils in acute inflammation

37. Monocytes

38. Cell number 1 is an eosinophil.
Cell number 2 is a basophil.

39. Granulomatous inflammation
Note the presence of multinucleated giant cells.
Also note that lymphocytes predominate in the areas surrounding the granuloma.

40. Granulomatous inflammation:
Langhan's giant cell
Note that the nuclei are arranged at the periphery of the cell.
This is a characteristic of Langhan's giant cells.
These cells are prominent in areas of granulomatous inflammation
but are not required for a diagnosis.

41. Abscess brain - Acute inflammation

42. Fibrinous pericarditis – Acute Inflammation

43. Purulent meningitis – Acute Inflammation

44. Pulmonary tuberculosis - chronic inflammation

45. Pulmonary tuberculosis - chronic inflammation

46. Pulmonary tuberculosis (detail 2)

47. Chronic inflammation
Tuberculous lymphadenitis (tuberculous granuloma)

48. Tuberculous lymphadenitis (tuberculous granuloma)
Detail -1

49. Tuberculous lymphadenitis (tuberculous granuloma)
Detail - 2

50. Chronic Inflammation
Foreign body granuloma

55. “ The whole art of teaching is
only art of awakening the natural
curosity of young minds for the
purpose of satisfying it
afterwards ”
Anatole France

56. Lymphocytic inflitration and the formation of non-caseating granuloma

57. Giant Cell

58. Touton Giant Cell

59. foreign body type giant cell

60. foreign body type giant cell

61. foreign body type giant cell

62. Abscess formation lung , gross

63. Acute and chronic inflammation , microscopic

64. Chronic inflammation with destruction of
bronchial wall , microscobic

65. Chronic inflammation with scarring , bronchus ,
Gross

66. chronic interstitial inflammation lung ,
microscobic

67. Erythema,Gross

68. exudate (pseudomemberanous enterocolitis)
,gross

69. Exudation microscopic

70. Exudation of fibrin, Microscopic

71. Fibrinous exudate pericardium ,gross

72. Fibrinous exudate pericardium ,microscopic

73. foamy macrophage 1

74. foamy macrophage 2

75. foamy macrophage 3

76. foamy macrophage 4

77. Inflammation with necrosis high power
microscopic

78. Inflammation with necrosis low power
microscopic

79. Margination &diapedesis of neutrophil ,Microscopic

80. Microscopic Neutrophilia

81. Ulceration , gastreic mucosa , Gross

82. Ulceration esophagus , microscobic

83. Ulceration larynx , Gross

84. macrophage phagocytosis

85. THE END
THANK YOU
“ Yesterday I dared to struggle
Today I dare to win ” Bernadette Devlin
For Comments & Suggestions
abbas_naseem@yahoo.com
Abbas Naseem
Dated: April 3, 2010