Japanese encephalitis is a mosquito-borne viral disease that is transmitted by Culex mosquitoes. It primarily affects children in rural Asia and is a major cause of viral encephalitis. The virus has a natural cycle between mosquitoes and pigs but can infect humans as well. There is no specific antiviral treatment, so prevention focuses on integrated vector control measures like larval source reduction and insecticide spraying, as well as vaccination in endemic areas. Vaccination provides good protection but must be maintained as immunity wanes over time.
Japanese Encephalitis and Filariasis are mosquito-borne diseases. Japanese Encephalitis is caused by a flavivirus transmitted by Culex mosquitoes. It is a seasonal disease prevalent from May to October in rural areas of Asia and the Pacific. Filariasis is caused by nematode worms Wuchereria bancrofti and Brugia malayi transmitted by Culex and Mansonia mosquitoes. It is widespread in tropical areas and a major cause of disability. Both diseases are associated with poverty and lack of sanitation, as mosquitoes breed in stagnant water. Control relies on integrated vector management including larval source reduction and insecticide spraying.
Rabies is a fatal viral disease transmitted through the saliva of infected mammals. It causes acute inflammation of the brain and is nearly 100% fatal in humans if left untreated. Dogs are the primary source of human rabies infections. Post-exposure prophylaxis, consisting of wound cleansing, rabies immune globulin injection, and a vaccine series, is highly effective in preventing the disease if administered promptly after exposure. No approved treatments exist once symptoms develop, making vaccination an important part of rabies prevention.
Mycobacterium tuberculosis and M. leprosy are the causative agents of tuberculosis and leprosy, respectively. M. tuberculosis is spread through the air and causes pulmonary tuberculosis, while M. leprosy causes leprosy through prolonged skin contact. Throughout history, tuberculosis has been a major global killer, responsible for 20% of deaths in London in 1600 and over 30% of deaths in Paris in 1800. The identification of the tubercle bacillus by Robert Koch in 1882 and subsequent discovery of treatments such as streptomycin in 1943 and isoniazid in 1952 led to major improvements in tuberculosis control and treatment. However, drug-resistant strains remain a serious problem.
This document discusses viral zoonotic diseases, with a focus on rabies. It defines zoonoses as diseases that can be transmitted between animals and humans. Rabies virus causes progressive infection of the central nervous system. Rabies occurs worldwide except Australia and Antarctica. Transmission is typically through bites from rabid animals, most commonly dogs. Symptoms in humans include pain at the bite site, hydrophobia, and paralysis. Laboratory diagnosis involves detecting the rabies virus or antibodies. Post-exposure prophylaxis includes wound cleansing, rabies immunoglobulin, and rabies vaccines. Prevention relies on surveillance, mass dog vaccination, population control, and public education.
Mycobacteria are thin, nonmotile, nonspore forming rods that are obligate aerobes and slow growing. They have a cell wall with high lipid content and mycolic acid. Mycobacteria include M. tuberculosis complex, nontuberculous mycobacteria (MOTT), and M. leprae. M. tuberculosis causes tuberculosis and grows optimally at 37C with 5-10% CO2. Its cell wall contains mycolic acids and other virulence factors that help it evade the host immune response. TB remains a major global health problem, infecting over 1/3 of the world's population.
Mycobacteria are thin, nonmotile, nonspore forming rods that are obligate aerobes and slow growing. They have a cell wall with high lipid content and mycolic acid. Mycobacteria include M. tuberculosis, M. leprae, and several non-tuberculosis mycobacteria (NTM). M. tuberculosis causes tuberculosis and has several virulence factors that allow it to survive inside host cells. TB remains a major global health problem, infecting over 1/3 of the world's population. M. leprae causes leprosy (Hansen's disease), which has an incubation period of 5-7 years.
Rabies is a fatal viral disease affecting the central nervous system caused by the Lyssavirus. It is transmitted primarily through animal bites, especially from rabid dogs which account for 99% of human cases in India. There are three main forms - urban rabies transmitted by domestic dogs, wildlife rabies perpetuated by animals like jackals and foxes, and bat rabies spread by vampire bats. Symptoms include malaise, headache and pain at the bite site followed by neurological symptoms like fear of water and light, increased salivation and spasms. Diagnosis involves identifying a history of animal bite and detecting the virus. Treatment is supportive and vaccination is given as post-exposure prophylaxis. Nursing care focuses on
Japanese Encephalitis and Filariasis are mosquito-borne diseases. Japanese Encephalitis is caused by a flavivirus transmitted by Culex mosquitoes. It is a seasonal disease prevalent from May to October in rural areas of Asia and the Pacific. Filariasis is caused by nematode worms Wuchereria bancrofti and Brugia malayi transmitted by Culex and Mansonia mosquitoes. It is widespread in tropical areas and a major cause of disability. Both diseases are associated with poverty and lack of sanitation, as mosquitoes breed in stagnant water. Control relies on integrated vector management including larval source reduction and insecticide spraying.
Rabies is a fatal viral disease transmitted through the saliva of infected mammals. It causes acute inflammation of the brain and is nearly 100% fatal in humans if left untreated. Dogs are the primary source of human rabies infections. Post-exposure prophylaxis, consisting of wound cleansing, rabies immune globulin injection, and a vaccine series, is highly effective in preventing the disease if administered promptly after exposure. No approved treatments exist once symptoms develop, making vaccination an important part of rabies prevention.
Mycobacterium tuberculosis and M. leprosy are the causative agents of tuberculosis and leprosy, respectively. M. tuberculosis is spread through the air and causes pulmonary tuberculosis, while M. leprosy causes leprosy through prolonged skin contact. Throughout history, tuberculosis has been a major global killer, responsible for 20% of deaths in London in 1600 and over 30% of deaths in Paris in 1800. The identification of the tubercle bacillus by Robert Koch in 1882 and subsequent discovery of treatments such as streptomycin in 1943 and isoniazid in 1952 led to major improvements in tuberculosis control and treatment. However, drug-resistant strains remain a serious problem.
This document discusses viral zoonotic diseases, with a focus on rabies. It defines zoonoses as diseases that can be transmitted between animals and humans. Rabies virus causes progressive infection of the central nervous system. Rabies occurs worldwide except Australia and Antarctica. Transmission is typically through bites from rabid animals, most commonly dogs. Symptoms in humans include pain at the bite site, hydrophobia, and paralysis. Laboratory diagnosis involves detecting the rabies virus or antibodies. Post-exposure prophylaxis includes wound cleansing, rabies immunoglobulin, and rabies vaccines. Prevention relies on surveillance, mass dog vaccination, population control, and public education.
Mycobacteria are thin, nonmotile, nonspore forming rods that are obligate aerobes and slow growing. They have a cell wall with high lipid content and mycolic acid. Mycobacteria include M. tuberculosis complex, nontuberculous mycobacteria (MOTT), and M. leprae. M. tuberculosis causes tuberculosis and grows optimally at 37C with 5-10% CO2. Its cell wall contains mycolic acids and other virulence factors that help it evade the host immune response. TB remains a major global health problem, infecting over 1/3 of the world's population.
Mycobacteria are thin, nonmotile, nonspore forming rods that are obligate aerobes and slow growing. They have a cell wall with high lipid content and mycolic acid. Mycobacteria include M. tuberculosis, M. leprae, and several non-tuberculosis mycobacteria (NTM). M. tuberculosis causes tuberculosis and has several virulence factors that allow it to survive inside host cells. TB remains a major global health problem, infecting over 1/3 of the world's population. M. leprae causes leprosy (Hansen's disease), which has an incubation period of 5-7 years.
Rabies is a fatal viral disease affecting the central nervous system caused by the Lyssavirus. It is transmitted primarily through animal bites, especially from rabid dogs which account for 99% of human cases in India. There are three main forms - urban rabies transmitted by domestic dogs, wildlife rabies perpetuated by animals like jackals and foxes, and bat rabies spread by vampire bats. Symptoms include malaise, headache and pain at the bite site followed by neurological symptoms like fear of water and light, increased salivation and spasms. Diagnosis involves identifying a history of animal bite and detecting the virus. Treatment is supportive and vaccination is given as post-exposure prophylaxis. Nursing care focuses on
Rabies is a fatal viral disease transmitted through the bites of rabid animals like dogs, cats, and wildlife. The rabies virus affects the central nervous system. In India, most human rabies cases result from bites by rabid domestic dogs. The rabies virus is excreted in an animal's saliva and transmitted via bites or contact between saliva and open wounds or mucous membranes. After exposure, symptoms may take 1-3 months to appear. Once symptoms develop, rabies is nearly always fatal. Post-exposure prophylaxis, including wound cleansing, vaccine, and possibly immunoglobulin administration, must begin as soon as possible to prevent onset of the disease.
This document provides an overview of medically relevant parasites presented by Dr. Karen Bennett. It discusses how parasites enter the body, replicate, and cause tissue damage. Cryptosporidium is highlighted as a parasite that causes diarrhea and is difficult to treat, especially in immunocompromised patients. It can be transmitted through contaminated water. Proper hygiene and water treatment are important for prevention. Laboratory diagnosis of parasitic diseases can be challenging but includes microscopic examination and newer techniques like PCR.
The document summarizes information about Epstein-Barr virus (EBV), including its morphology, classification, epidemiology, transmission, pathogenicity, infectious mononucleosis, laboratory diagnosis, associated malignancies like nasopharyngeal carcinoma and Burkitt's lymphoma. EBV is ubiquitous and causes lifelong infection, often spreading through saliva. It infects B cells and can become latent or lytic, sometimes causing infectious mononucleosis. Associated cancers are linked to viral reactivation.
This document provides an overview of rabies including its causative agent, transmission, pathogenesis, types, diagnosis, management, and prevention. Rabies is a fatal viral disease transmitted through animal bites that causes encephalitis. The rabies virus is in the Rhabdoviridae family and spreads from the site of a bite to the central nervous system. Post-exposure prophylaxis including wound cleaning and vaccination is highly effective in preventing death from rabies if administered promptly after exposure.
The document summarizes key information about rabies, including:
1. Rabies is a viral disease transmitted through bites or scratches from infected animals like dogs, foxes, and bats.
2. The virus travels from the site of infection to the central nervous system, where it causes acute inflammation and symptoms like fear of water, muscle spasms, and paralysis.
3. There is no cure for rabies, but post-exposure prophylaxis including wound cleaning and rabies vaccinations can prevent the disease if administered promptly after exposure.
The document discusses arboviruses, which are viruses transmitted by arthropod vectors like mosquitoes and ticks. It describes the characteristics and transmission cycles of arboviruses, examples of diseases they cause like dengue, yellow fever and Japanese encephalitis, and the viruses that cause these diseases including togaviruses and flaviviruses. Key information provided includes the virus families and genera, vectors involved in transmission, symptoms of associated diseases, and prevention and treatment methods.
This document discusses Cryptosporidium parvum, the causative agent of cryptosporidiosis. It belongs to the phylum Apicomplexa and commonly infects the intestinal tract of calves and other mammals. It has a direct life cycle involving the ingestion of sporulated oocysts followed by asexual and sexual reproduction within intestinal epithelial cells. Infection can cause diarrhea in calves and severe, prolonged illness in immunocompromised humans. Diagnosis involves identification of oocysts in feces and treatment is generally supportive due to lack of effective drugs. Control relies on hygiene, water treatment, and isolation of infected animals.
Mycobacterium tuberculosis-importance of TB day,classification of Mycobacterium species,Details on Mycobacterium tuberculosis-morphology,culture,resistance,biochemical reactions,antigenic characters,mode of transmission,pathogenesis,complications,lab diagnosis,treatment,DOTS Strategy and prophylaxis
Systematic bacteriology, also known as bacterial taxonomy or bacterial systematics, is a branch of microbiology that focuses on the classification, identification, and naming of bacteria. It plays a crucial role in organizing and understanding the diversity of bacteria, which are a diverse group of microorganisms with a wide range of shapes, sizes, and metabolic capabilities
Fungal and anti fungal agents detailed information .pptxRafiaRayanabtbc
This document discusses antifungal agents. It begins by describing fungi and their cell walls, which are made of chitin and ergosterol. It then discusses the classification of fungal infections and organisms like yeasts, molds, and dimorphic fungi. The document covers various antifungal drug classes including azoles, polyenes, echinocandins, and antimetabolites. It provides details on important antifungals like amphotericin B, fluconazole, caspofungin, and their mechanisms of action, uses, and side effects in treating serious fungal infections.
This document provides an overview of zoonotic tuberculosis, which is caused by Mycobacterium bovis and can be transmitted from animals to humans. Key points include:
- M. bovis is one of the main causes of non-pulmonary tuberculosis in humans. It is transmitted through the consumption of unpasteurized dairy or undercooked meat.
- Globally, it is estimated that there are 147,000 new cases of zoonotic tuberculosis annually, with the highest burdens in Africa and Southeast Asia.
- In animals, cattle are the main reservoir and transmission can occur through aerosols or ingestion. Signs include emaciation, fever, and respiratory distress.
Rabies is a fatal viral disease transmitted through the saliva of infected mammals, mostly dogs. It causes an estimated 59,000 human deaths annually worldwide, with the majority in Asia and Africa. In Nepal, around 30,000 cases occur annually in pets and over 100 human cases. It is transmitted through bites or scratches that allow the virus access to the central nervous system. Post-exposure prophylaxis within days of exposure can prevent disease if administered promptly according to WHO guidelines. There is no cure once symptoms develop.
Chikungunya virus is an alphavirus transmitted by Aedes mosquitoes that causes fever and joint pain. It was first identified in Tanzania in 1952. An outbreak in 2005-2006 affected over 250,000 people on Réunion Island with 200 associated deaths. The virus is maintained in a mosquito-human transmission cycle and causes acute, self-limiting fever and arthralgia. There is no vaccine or antiviral treatment, so prevention focuses on eliminating mosquito breeding sites and limiting exposure to bites.
This document discusses respiratory infections like smallpox and chickenpox. Smallpox was eradicated in the 20th century through international cooperation and vaccination efforts. Chickenpox is caused by the varicella zoster virus and presents as a rash that spreads from the trunk to the extremities. It most commonly affects children under 10 years old. Complications can occur in immunocompromised individuals. Diagnosis is usually clinical and treatment is supportive.
Rabies is a viral disease transmitted through the bites of rabid animals. It causes 59,000 human deaths annually, with over 95% occurring in Africa and Asia. Rabies virus infects the nervous system and is fatal if left untreated. The document discusses rabies epidemiology, etiology, transmission, incubation period, clinical signs including hydrophobia, diagnosis, management, and prevention through post-exposure prophylaxis including wound cleansing and vaccination, and pre-exposure prophylaxis for at-risk groups like veterinarians. Rabies remains a major public health problem in Yemen, with 148 reported human deaths annually and a vaccination coverage of only 18.5% of dogs.
Leishmaniasis is caused by protozoan parasites of the genus Leishmania and transmitted via the bite of infected female phlebotomine sandflies. It presents in various forms including visceral leishmaniasis (kala-azar), cutaneous leishmaniasis, and muco-cutaneous leishmaniasis. The life cycle involves vertebrate hosts such as dogs, rodents, and humans that serve as reservoirs, as well as insect vectors. Transmission is influenced by environmental, host, and parasite factors. Clinical features and diagnosis depend on the infecting species and form of the disease. Treatment involves antileishmanial drugs while control relies on reservoir and vector control.
This document discusses rabies, a viral disease transmitted through animal bites that affects the central nervous system. Some key points:
- Rabies causes 59,000 human deaths annually, mostly in Africa and Asia. Dogs are responsible for 99% of human rabies through bites.
- After an incubation period, symptoms include hyperactivity, hydrophobia, and paralysis. It is almost always fatal without post-exposure prophylaxis.
- Louis Pasteur developed the first rabies vaccine in 1890. Modern cell-culture vaccines have replaced nerve tissue vaccines. Post-exposure prophylaxis includes wound cleaning and a series of vaccine doses, with rabies immunoglobulin for severe exposures.
- In India, rabies causes
case presentation on post kala azar dermal leishmaniasis (PKDL)ChristyThomas37
This document presents a case study of post-kala azar dermal leishmaniasis (PKDL) in a 13-year old female patient who was previously treated for kala azar at age 6. Examinations found papular and nodular lesions on her face and macular lesions on her body. Diagnostic tests confirmed Leishmania parasites. She was diagnosed with PKDL and treated with liposomal amphotericin B and miltefosine. PKDL is usually a sequel of visceral leishmaniasis occurring months to years after treatment, characterized by skin lesions, and requires treatment to prevent further spread.
Bordetella is a genus of Gram-negative bacteria that includes three human pathogens: B. pertussis, B. parapertussis, and B. bronchiseptica. B. pertussis causes pertussis (whooping cough) in humans. The bacteria are small, aerobic, non-fermentative, and fastidious. They produce several virulence factors like pertussis toxin and filamentous hemagglutinin that contribute to pathogenesis. Pertussis has an incubation period of 1-2 weeks and presents as a catarrhal stage followed by paroxysmal coughing spells characterized by a "whoop". It is highly contagious and vaccine-preventable
This document provides an overview of the history and evolution of medicine. It describes how medicine originated from primitive practices involving supernatural beliefs. It then discusses the development of early systems of medicine in places like India, China, Egypt, and Mesopotamia. Key figures that advanced medical knowledge are highlighted from each era, such as Susruta, Hippocrates, Galen, Ibn Sina, and Pasteur. Major milestones like the germ theory of disease and advances in preventive medicine through vaccination are also summarized. The document concludes by describing the modern fields of curative, preventive, and social medicine.
This document discusses various types of communication including one-way communication, two-way communication, verbal communication, non-verbal communication, formal and informal communication, and visual communication. It also addresses telecommunication, barriers to communication, functions of health communication, approaches to health education, principles of health education, and methods used in health communication including individual, group, and mass approaches.
Rabies is a fatal viral disease transmitted through the bites of rabid animals like dogs, cats, and wildlife. The rabies virus affects the central nervous system. In India, most human rabies cases result from bites by rabid domestic dogs. The rabies virus is excreted in an animal's saliva and transmitted via bites or contact between saliva and open wounds or mucous membranes. After exposure, symptoms may take 1-3 months to appear. Once symptoms develop, rabies is nearly always fatal. Post-exposure prophylaxis, including wound cleansing, vaccine, and possibly immunoglobulin administration, must begin as soon as possible to prevent onset of the disease.
This document provides an overview of medically relevant parasites presented by Dr. Karen Bennett. It discusses how parasites enter the body, replicate, and cause tissue damage. Cryptosporidium is highlighted as a parasite that causes diarrhea and is difficult to treat, especially in immunocompromised patients. It can be transmitted through contaminated water. Proper hygiene and water treatment are important for prevention. Laboratory diagnosis of parasitic diseases can be challenging but includes microscopic examination and newer techniques like PCR.
The document summarizes information about Epstein-Barr virus (EBV), including its morphology, classification, epidemiology, transmission, pathogenicity, infectious mononucleosis, laboratory diagnosis, associated malignancies like nasopharyngeal carcinoma and Burkitt's lymphoma. EBV is ubiquitous and causes lifelong infection, often spreading through saliva. It infects B cells and can become latent or lytic, sometimes causing infectious mononucleosis. Associated cancers are linked to viral reactivation.
This document provides an overview of rabies including its causative agent, transmission, pathogenesis, types, diagnosis, management, and prevention. Rabies is a fatal viral disease transmitted through animal bites that causes encephalitis. The rabies virus is in the Rhabdoviridae family and spreads from the site of a bite to the central nervous system. Post-exposure prophylaxis including wound cleaning and vaccination is highly effective in preventing death from rabies if administered promptly after exposure.
The document summarizes key information about rabies, including:
1. Rabies is a viral disease transmitted through bites or scratches from infected animals like dogs, foxes, and bats.
2. The virus travels from the site of infection to the central nervous system, where it causes acute inflammation and symptoms like fear of water, muscle spasms, and paralysis.
3. There is no cure for rabies, but post-exposure prophylaxis including wound cleaning and rabies vaccinations can prevent the disease if administered promptly after exposure.
The document discusses arboviruses, which are viruses transmitted by arthropod vectors like mosquitoes and ticks. It describes the characteristics and transmission cycles of arboviruses, examples of diseases they cause like dengue, yellow fever and Japanese encephalitis, and the viruses that cause these diseases including togaviruses and flaviviruses. Key information provided includes the virus families and genera, vectors involved in transmission, symptoms of associated diseases, and prevention and treatment methods.
This document discusses Cryptosporidium parvum, the causative agent of cryptosporidiosis. It belongs to the phylum Apicomplexa and commonly infects the intestinal tract of calves and other mammals. It has a direct life cycle involving the ingestion of sporulated oocysts followed by asexual and sexual reproduction within intestinal epithelial cells. Infection can cause diarrhea in calves and severe, prolonged illness in immunocompromised humans. Diagnosis involves identification of oocysts in feces and treatment is generally supportive due to lack of effective drugs. Control relies on hygiene, water treatment, and isolation of infected animals.
Mycobacterium tuberculosis-importance of TB day,classification of Mycobacterium species,Details on Mycobacterium tuberculosis-morphology,culture,resistance,biochemical reactions,antigenic characters,mode of transmission,pathogenesis,complications,lab diagnosis,treatment,DOTS Strategy and prophylaxis
Systematic bacteriology, also known as bacterial taxonomy or bacterial systematics, is a branch of microbiology that focuses on the classification, identification, and naming of bacteria. It plays a crucial role in organizing and understanding the diversity of bacteria, which are a diverse group of microorganisms with a wide range of shapes, sizes, and metabolic capabilities
Fungal and anti fungal agents detailed information .pptxRafiaRayanabtbc
This document discusses antifungal agents. It begins by describing fungi and their cell walls, which are made of chitin and ergosterol. It then discusses the classification of fungal infections and organisms like yeasts, molds, and dimorphic fungi. The document covers various antifungal drug classes including azoles, polyenes, echinocandins, and antimetabolites. It provides details on important antifungals like amphotericin B, fluconazole, caspofungin, and their mechanisms of action, uses, and side effects in treating serious fungal infections.
This document provides an overview of zoonotic tuberculosis, which is caused by Mycobacterium bovis and can be transmitted from animals to humans. Key points include:
- M. bovis is one of the main causes of non-pulmonary tuberculosis in humans. It is transmitted through the consumption of unpasteurized dairy or undercooked meat.
- Globally, it is estimated that there are 147,000 new cases of zoonotic tuberculosis annually, with the highest burdens in Africa and Southeast Asia.
- In animals, cattle are the main reservoir and transmission can occur through aerosols or ingestion. Signs include emaciation, fever, and respiratory distress.
Rabies is a fatal viral disease transmitted through the saliva of infected mammals, mostly dogs. It causes an estimated 59,000 human deaths annually worldwide, with the majority in Asia and Africa. In Nepal, around 30,000 cases occur annually in pets and over 100 human cases. It is transmitted through bites or scratches that allow the virus access to the central nervous system. Post-exposure prophylaxis within days of exposure can prevent disease if administered promptly according to WHO guidelines. There is no cure once symptoms develop.
Chikungunya virus is an alphavirus transmitted by Aedes mosquitoes that causes fever and joint pain. It was first identified in Tanzania in 1952. An outbreak in 2005-2006 affected over 250,000 people on Réunion Island with 200 associated deaths. The virus is maintained in a mosquito-human transmission cycle and causes acute, self-limiting fever and arthralgia. There is no vaccine or antiviral treatment, so prevention focuses on eliminating mosquito breeding sites and limiting exposure to bites.
This document discusses respiratory infections like smallpox and chickenpox. Smallpox was eradicated in the 20th century through international cooperation and vaccination efforts. Chickenpox is caused by the varicella zoster virus and presents as a rash that spreads from the trunk to the extremities. It most commonly affects children under 10 years old. Complications can occur in immunocompromised individuals. Diagnosis is usually clinical and treatment is supportive.
Rabies is a viral disease transmitted through the bites of rabid animals. It causes 59,000 human deaths annually, with over 95% occurring in Africa and Asia. Rabies virus infects the nervous system and is fatal if left untreated. The document discusses rabies epidemiology, etiology, transmission, incubation period, clinical signs including hydrophobia, diagnosis, management, and prevention through post-exposure prophylaxis including wound cleansing and vaccination, and pre-exposure prophylaxis for at-risk groups like veterinarians. Rabies remains a major public health problem in Yemen, with 148 reported human deaths annually and a vaccination coverage of only 18.5% of dogs.
Leishmaniasis is caused by protozoan parasites of the genus Leishmania and transmitted via the bite of infected female phlebotomine sandflies. It presents in various forms including visceral leishmaniasis (kala-azar), cutaneous leishmaniasis, and muco-cutaneous leishmaniasis. The life cycle involves vertebrate hosts such as dogs, rodents, and humans that serve as reservoirs, as well as insect vectors. Transmission is influenced by environmental, host, and parasite factors. Clinical features and diagnosis depend on the infecting species and form of the disease. Treatment involves antileishmanial drugs while control relies on reservoir and vector control.
This document discusses rabies, a viral disease transmitted through animal bites that affects the central nervous system. Some key points:
- Rabies causes 59,000 human deaths annually, mostly in Africa and Asia. Dogs are responsible for 99% of human rabies through bites.
- After an incubation period, symptoms include hyperactivity, hydrophobia, and paralysis. It is almost always fatal without post-exposure prophylaxis.
- Louis Pasteur developed the first rabies vaccine in 1890. Modern cell-culture vaccines have replaced nerve tissue vaccines. Post-exposure prophylaxis includes wound cleaning and a series of vaccine doses, with rabies immunoglobulin for severe exposures.
- In India, rabies causes
case presentation on post kala azar dermal leishmaniasis (PKDL)ChristyThomas37
This document presents a case study of post-kala azar dermal leishmaniasis (PKDL) in a 13-year old female patient who was previously treated for kala azar at age 6. Examinations found papular and nodular lesions on her face and macular lesions on her body. Diagnostic tests confirmed Leishmania parasites. She was diagnosed with PKDL and treated with liposomal amphotericin B and miltefosine. PKDL is usually a sequel of visceral leishmaniasis occurring months to years after treatment, characterized by skin lesions, and requires treatment to prevent further spread.
Bordetella is a genus of Gram-negative bacteria that includes three human pathogens: B. pertussis, B. parapertussis, and B. bronchiseptica. B. pertussis causes pertussis (whooping cough) in humans. The bacteria are small, aerobic, non-fermentative, and fastidious. They produce several virulence factors like pertussis toxin and filamentous hemagglutinin that contribute to pathogenesis. Pertussis has an incubation period of 1-2 weeks and presents as a catarrhal stage followed by paroxysmal coughing spells characterized by a "whoop". It is highly contagious and vaccine-preventable
This document provides an overview of the history and evolution of medicine. It describes how medicine originated from primitive practices involving supernatural beliefs. It then discusses the development of early systems of medicine in places like India, China, Egypt, and Mesopotamia. Key figures that advanced medical knowledge are highlighted from each era, such as Susruta, Hippocrates, Galen, Ibn Sina, and Pasteur. Major milestones like the germ theory of disease and advances in preventive medicine through vaccination are also summarized. The document concludes by describing the modern fields of curative, preventive, and social medicine.
This document discusses various types of communication including one-way communication, two-way communication, verbal communication, non-verbal communication, formal and informal communication, and visual communication. It also addresses telecommunication, barriers to communication, functions of health communication, approaches to health education, principles of health education, and methods used in health communication including individual, group, and mass approaches.
This document summarizes key epidemiological factors related to smallpox, chickenpox, and measles. For smallpox, it notes factors that enabled its eradication like lack of animal reservoirs, effective vaccination, and distinctive rash allowing easy detection. For chickenpox, it outlines agent, host, environmental transmission factors and clinical features. For measles, it provides global burden, India statistics, epidemiological determinants like transmission via droplets, and prevention through vaccination or immunoglobulin administration.
This document discusses the importance of communication skills in medical practice. It outlines seven competencies for effective doctor-patient communication: building a relationship, opening the discussion, gathering information, understanding the patient's perspective, sharing information, reaching agreement, and providing closure. For each competency, it provides tips and guidelines on how to demonstrate care, show respect, ask open-ended questions, actively listen, explain diagnoses and plans, and ensure mutual understanding. The overall message is that strong interpersonal communication is integral to quality patient care.
- Influenza is caused by influenza viruses types A, B, and C. Type A causes pandemics every 10-15 years due to antigenic variation. The most recent pandemics were the Spanish Flu in 1918, Asian Flu in 1957, and Hong Kong Flu in 1968.
- Bird flu is caused by the H5N1 virus and can infect humans. It is usually fatal in birds and sometimes infects humans through contact with infected birds. Human to human transmission is rare but possible if the virus mutates.
- SARS is a viral respiratory disease caused by a coronavirus. It emerged in 2002-2003 with symptoms including fever, cough, and difficulty breathing which can progress to pneumonia. It was
Cholera is an acute diarrheal illness caused by the bacteria Vibrio cholerae. It is transmitted through contaminated food or water and causes a rapid loss of fluids and electrolytes through profuse diarrhea. Treatment involves oral or intravenous rehydration to replace lost fluids, along with antibiotics to shorten the duration of illness. Prevention relies on access to clean water, proper sanitation, and hygiene education to reduce transmission.
Cholera is an acute diarrheal disease caused by the bacterium Vibrio cholerae. It remains a global threat, with an estimated 2.9 million cases and 95,000 deaths worldwide annually. The disease spreads through contaminated food and water and can kill within hours if left untreated. Cholera outbreaks typically occur in areas with poor sanitation and lack of clean drinking water. Prevention relies on vaccination, water treatment, hygiene and proper sanitation.
Through lifestyle modifications like diet, exercise, yoga, meditation and stress management, the risk of developing diabetes can be reduced. A healthy diet low in refined carbs and sugar but high in fiber is recommended. Regular exercise of at least 40 minutes per day helps control blood sugar levels. Yoga and meditation lower stress levels and insulin resistance. Proper sleep, social support and avoiding pollution further help in diabetes prevention. Timely screening and lifestyle changes can prevent or delay the onset of diabetes and its complications.
This document provides an overview of descriptive epidemiology. It defines descriptive studies as those that describe the frequency and distribution of an outcome without a comparison group. The main objectives are to describe disease incidence/prevalence, natural history, and distribution according to person, place and time variables. Descriptive studies make hypotheses about causes but do not confirm them. Key aspects include describing disease occurrence by time, place and person; measuring disease burden; and formulating etiological hypotheses.
An outbreak of endophthalmitis has occurred in patients who underwent surgery at a district hospital. The document discusses how to investigate this outbreak using different study designs. It recommends using a case-control study design to evaluate the association between surgery at the hospital and developing endophthalmitis. It provides details on how to conduct a case-control study, including selecting cases and controls, collecting exposure data, and calculating odds ratios to assess strength of association.
Cholera is an acute diarrheal illness caused by the bacteria Vibrio cholerae. It causes a rapid loss of fluids and electrolytes from the intestines that can lead to dehydration, shock, and even death if untreated. The classic symptoms include painless watery diarrhea and vomiting. Treatment involves oral or intravenous rehydration to replace lost fluids, along with antibiotics to kill the bacteria. Patients are discharged once they can tolerate oral intake and their diarrhea and urinary output returns to normal levels. Cholera remains a global threat, especially in areas with poor sanitation and lack of clean water.
This document discusses the Dengue Syndrome and summarizes key information about Dengue Fever and Dengue Hemorrhagic Fever. It notes that over 2.5 billion people worldwide live in areas where dengue viruses can be transmitted. The document describes the symptoms, diagnosis, and grading of severity for Dengue Fever and Dengue Hemorrhagic Fever. It also provides information on treatment, control measures, and discusses another similar disease, Chikungunya Fever.
Cholera is caused by the bacteria Vibrio cholerae and is transmitted through contaminated food or water. It causes severe diarrhea and dehydration that can be fatal if untreated. The primary treatment is oral rehydration therapy. Prevention focuses on access to clean water, sanitation, vaccination in high risk areas, and public health education on hygiene practices.
Influenza is an acute respiratory infection caused by influenza viruses types A, B, and C. Type A strains have caused all known pandemics. The virus is highly contagious and spreads rapidly through droplets. It commonly causes epidemics every 2-3 years for influenza A and 4-7 years for influenza B. While most cases are mild, influenza can lead to complications like pneumonia. Vaccination and antiviral drugs can help prevent and treat the disease. Good hygiene and avoiding crowded areas during outbreaks are also recommended.
Cancer is characterized by abnormal cell growth that can invade tissues and spread to distant organs, potentially causing death. The three main types are carcinoma, sarcoma, and leukemia/lymphoma. Worldwide, cancer causes over 6 million deaths annually. In India, the most common cancers are oral, esophageal, stomach and lung cancers in men, and breast, cervical, oral and esophageal cancers in women. Environmental factors like tobacco, alcohol, diet, occupation and infection can increase cancer risk, as can genetic factors. Prevention focuses on reducing risk factors, screening and early detection, and treatment. Breast cancer is the most common cancer in women worldwide. Cervical cancer is also very common in India, where screening programs
Bird flu, or avian influenza, is a viral infection that commonly infects birds like chickens, ducks, and turkeys. The H5N1 strain is particularly deadly and can be transmitted from birds to humans. Symptoms in humans include fever, cough, and possible complications like hypoxemia and organ dysfunction. While human-to-human transmission is rare, there is a risk of mutation allowing easier spread between humans. Treatment involves antiviral drugs, isolation, and supportive care. Prevention focuses on proper handling of infected birds and their products as well as hygiene practices.
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3. INTRODUCTION
MOSQUITO BORNE ENCEPHALITIS
CAUSED BY GROUP B ARBOVIRUS
(FLAVI VIRUS) AND
TRANSMITTED
BY CULICINE MOSQUITOES.
ZOONOTIC DISEASE
(METAZOONOSES)
RURAL DISAEASE
ICEBERG DISEASE
EXHIBITS CYCLICAL TREND
4. HISTORY
1871 JAPANESE ENCEPHALITIS
DESCRIBED IN JAPAN.
1934 JAPANESE ENCEPHALITIS
VIRUS
WAS ISOLATED.
5. WORLD SCENARIO
50000 CASES OF JE OCCUR GLOBALLY EACH
YEAR WITH 11000 DE ATHS AND NEARLY
9000 DISABLED.
SPORADIC CASES (Occasional cases, widely
distributed in time and place): are observed in
China, Japan, Taiwan, Korea, Philippines,
Indonesia, Malaysia, Singapore, Myanmar,
Bangladesh and Eastern areas of Russia.
REGIONAL, SEASONAL OUTBREAKS :
Occurs in Thailand, parts of India and Sri lanka.
6.
7. INDIAN SCENARIO
JE first isolated in 1955 at Vellore, Tamil
Nadu.
Subsequently, the outbreaks have occurred
in 25 States / Union Territories of India.
JE virus infection is widespread and is
particularly very high in Southern States of
India viz., Andhra Pradesh (AP) Tamil Nadu
and some parts of Karnataka.
8.
9. NB: Indian authorities have reported 6171 cases
nation-wide, including 5700 cases and 1315 deaths in
Uttar Pradesh alone.
YEAR CASES DEATHS
1998
1999
2000
2001
2002
2003
2004
2005
2120
3428
2593
2061
1765
2241
1695
6200
507
680
556
479
460
670
367
1315
INCIDENCE OF JE
12. ANIMAL RESERVOIRS
PIGS
MAJOR VERTEBRATE HOSTS
CONSIDERED AS ‘AMPLIFIERS’ OF VIRUS
CATTLES/BUFFALOES
NOT NATURAL HOSTS OF JE VIRUS
ACT AS ’MOSQUITC ATTRACTANTS’
BIRDS
POND HERONS,CATTLE
ERGETS,POULTRY,DUCKS
NB:HORSES ARE ONLY ANIMALS WHICH MANIFEST
JE VIRUS INFECTION.
13.
14. HOST FACTORS
AGE:
MAJORITY OF CASES ARE CHILDREN LESS THAN 15
YEARS (85%) OR OVER 60 YEARS (10%).
SEX:
MALES ARE MORE AFFECTED THAN FEMALES.
POPULATION MOBILITY
MIGRATION OF PEOPLE FROM ENDEMIC AREAS TO
RCEPTIVE AREAS.
OCCUPATION
MOSTLY A RURAL DISEASE ,CLOSELY RELATED TO
AGRICULTURAL PRACTISES.
15. ENVIRONMENTAL
FACTORS
SEASON
JE IS A SEASONAL DISEASE
PREVALENCE IS FROM MAY
TO OCTOBER ( RELATED TO
AGRICULTURAL PRACTICES).
RAINFALL
INCREASES THE OPPORTUNITIES FOR
BREEDING OF MOSQUITOES.
16. VECTOR OF JE
CULICINE MOSQUITOES.
(C.TRITAENIORHYNCHUS,C.VISHNUI,
C.GELIDUS)
SOME ANOPHELINES.
C.TRITAENIORHYNCHUS HAS BEEN
IMPLICATED AS IMPORTANT VECTOR
IN SOUTH INDIA.
17. HABITS
BREEDING HABITS
BREED IN RICE FIELDS,
SHALLOW DITCHES
AND POOLS.
CHOICE OF HOST
ZOOPHILIC,FEEDING PRIMARILY ON ANIMAL
HOSTS.
TIME OF BITING
USUALLY AT NIGHTS.
18. MODES OF TRANSMISSION
DISEASE IS TRANSMITTED TO MAN BY BITE OF
INFECTED MOSQUITOES.
NO MAN TO MAN TRANSMISSION
MAN IS INCIDENTAL “DEAD END” HOST.
INCUBATION PERIOD
VARIES FROM 5-15 DAYS
20. PATHOGENESIS
Neurotransmitter receptors are involved in binding of JE
virus to cells in CNS.
Sensitized T cells stimulate inflammatory
Response by activating macrophages, lymphocytes
Perivascular space and parenchyma to form glial nodules
CD4 T cells - CFS, parenchyma
B cells - perivascular space
22. CLINICAL FEATURES
Incubation period-5 to 16 days
Disease:asymptomatic infection=1:250 to 1:1000
Represents tip of iceberg
Disease depends on –severity of infection
susceptibility of host
location of agent
It is characterized by CNS involvement
Japanese encephalitis is also called BRAINFEVER
23. SYMPTOMS AND SIGNS
PRODROMAL PHASE:-
High grade fever,
headache
malaise
Duration :6 days
ENCEPHALITIC STAGE:-
High fever, severe head ache, nuchal rigidity, focal
CNS signs, seizures, altered sensorium, abnormal
doll’s eye moments, absent corneal reflex, pupillary
reflex, deviation of angle of mouth, loss of
consciousness etc.
Symptoms and signs of raised ICT-headache, vomiting,
hemiplegia,bradycardia,irregular breathing.
Signs and symptoms of meningeal irration-kernigs sign
26. LATE STAGE:- Begins when active inflammation
is at end i.e.temp. and ESR touch normal
Mental impairment
Increased deep tendon reflexes
Paresis of UMN lesion
- LMN lesion type
- Speech impairment
COMPLICATIONS:-
Death 35 - 50% - short prodromal stage
- deep coma
- hypertonia
- tachypnea
NB:If patient survives, complications are as that of
late stage.
JE is the disease in children with early mortality.
27. DIAGNOSIS
Clinical signs and symptoms
LAB DIAGNOSIS:-
CSF lymphocytic pleocytosis
Normal glucose level
SEROLOGICAL TESTS:-
Detection of IgM antibodies –first week
NEW SEROLOGICAL TEST:-
ELISA shows sensitivity of 88% -with sera
81% -with CSF
35. Principles of Control :
• No specific treatment per se.
• Vector control is the main mode of
prevention of an individual and
community as a whole.
• Control of amplifier hosts.
• Vaccination.
36. Management of J E
Only symptomatic treatment
• maintenance of airway
• fluid and electrolyte balance
• control of convulsions,
raised ICP, temperature
37. VECTOR CONTROL
VECTORS: C.tritaenorhynchus,C.gelidus C.vishnui.
Principles of arthropod control:
• Environmental control
• Chemical control
• Biological control
• Genetic control
• Newer methods
NB :”Integrated approach”
39. • Mosquito control measures:
1.Anti larval measures
2.Anti adult measures
3.Personal protection
ANTI LARVAL MEASURES
1.Environmental control :best approach as results
are more permanent.
a. Source reduction-elimination of cesspools,
ditches.
b. Intermittent irrigation
c. Filling and drainage operation
d. Provision of piped water supply
e. Proper disposal of refuse.
40.
41. • 2.Chemical control:
Commonly used larvicides are
• a. Mineral oil –diesel oil, kerosene, mosquito
larvicidal oil, etc.
MOA :oil spreads and forms thin film which cuts
air supply to larvae .appl rate - 40to90 L/hectare
once a week.
• b. Paris Green -[copper acetoarsenite] Micro
crystalline powder insoluble in water.
MOA-stomach poison. good sample contains 50%
arsenious oxide. Appl-2% dust which is prepared
by adding 2kg of Paris green and 8kg of diluent
such as slaked lime in a rotary mixer. Its dusted
by hand, rotary blowers. Dosage 1kg/hectare of
water surface.
42. c. Synthetic Insecticides - Organophosphorus
compounds like FENTHION, CHLORPYRIFOS,
ABATE etc.
abate-very effective and least toxic.ccn.-1ppm.
Toxicant Dosage/ha]
Abate 56-112
Fenthion 22-112
Chloropyrifos 11-16
3.Biological control- Small fish like Gambusia,
lebister which feed on larvae can be use in
burrow pits, cesspools etc.
44. • ANTI-ADULT MEASURES-
1. Residual sprays -DDT is the insecticide of choice.
Dosage 1-2g of pure DDT / sq.m applied 1-3 times a year
to walls and other surfaces. Malathion, propoxur- applied
where DDT resistance encountered.
Toxicant dosage[g/sqm] avg,durationof
effectiveness
DDT 1-2 6-12 months
Malathion 2 3 “
2. Space sprays- sprayed into the atmosphere in the
form of fog or mist using hand guns or power sprays
a. Pyrethrum extract- excellant spray from pyrethrum
flowers. Active principle-pyrethrin is a nerve poison dose -
1oz/1000 cft.
b. Residual insecticides- Malathion ,Fenitrothion for ULV
fogging.
47. • 3. Genetic control- sterile male
technique,cytoplasmic
incompatability,chromosomal translocation
• Newer methods -insect growth
regulators,chemosterilants etc.
PERSONAL PROTECTION
[i] Mosquito nets - size of the holes 0.0475”
no. of holes/sq inch 150
[ii] Screening of buildings –Cu or Bronze gauze with
16 meshes/inch
[iii] Mosquito repellants or culicifuges-used mainly
on skin. Ex. Deet all-purpose
repellant
“INTEGRATED APPROACH”
50. VACCINATION
• Active Immunization -worldwide 3 JE vaccines are present.
1.Inactivated mouse brain killed vaccine
2. “ Primary Hamster kidney,
3.Live attenuated PHK
Passive Immunization Ig’s are not available.
INACTIVATED MOUSE BRAIN KILLED VACCINE
Central Research institute ,Kasauli has developed this
vaccine.
VIRAL STRAIN- Nakayama strain of JE virus isolated from
spinal fluid of a human case in 1935 and maintained by cont.
mouse brain passage.
DOSAGE AND ROA-
1st-------------2nd--------------3rd-----------booster
7-14 d 1mnth 3yrs
Adults – 1ml dose s.c.
Children[1-3yrs] – 0.5 ml s.c.
51. INDICATIONS:
a. Endemic areas-In rural areas of Asia where intense JE
virus transmission through enzootic life cycle leads to high
risk of exposure at an early age. In such areas UNIVERSAL
PRIMARY IMMUNIZATION is indicated for children[1-
2yrs].Also in areas agricultural developed like Thailand &
Japan. In these areas immunity should be maintained
up to 10 yrs of age.
b. Expatriates in areas of endemic.
c. Travelers
d. Researchers and LAB workers.
CONTRAINDICATIONS :people allergic to rodent derived
products.
ADVERSE EFFECTS: Swelling ,redness and tenderness in 20%
vaccinees. Low grade fever and Myalgia in 10- 30% and
Post vaccination neurologic deficits.
EFFICACY : 60-80%
54. • Vaccination is not recommended as outbreak control
measure as it takes 1 month after the 2nd dose to develop
antibodies at protective levels and outbreaks are short lived
• CONTROL OF PIGS -As pigs are amplifier host, piggeries
should be 4-5 km away from human habitat.
Disposal of garbage and sewage should be done
appropriately so that breeding of pigs can be controlled.
LEVELS OF PREVENTION:
• PRIMARY PREVENTION:
• HEALTH PROMOTION:
EFFICIENT CONTROL OF MOSQUITO AND OTHER
AMPLIFIER HOSTS LIKE PIGS AND EGRETS.
HEALTH EDUCATION
• SPECIFIC PROTECTION:
DEVELOPMENT OF SAFE AND STANDARD VACCINE.
PERSONAL PROTECTION MEASURES AGAINST MOSQUITOS
• SECONDARY PREVENTION:
EARLY DIAGNOSIS: Its possible through surveillance
55. There are 3 types of surveillance
1. Sero-surveillance in high risk groups, animals and birds.
2. Vector surveillance for vector density and infection
3. Case surveillance
A. where no JE transmission is detected but vector is
present [acute CNS syndromes, fever clustering.]
b. where it is endemic or epidemic [weekly or monthly
reporting on suspected or probable or confirmed cases]
EARLY TREATMENT : its symptomatic.
TERTIARY PREVENTION :Rehabilitation of paralytic
patients by physiotherapy.
Technical support for surveillance, epidemiological monitoring
of the disease, for outbreak investigations and control is
provided by state health authorities.
56. Inspite of all these methods Control of JE is difficult
because-
• Outdoor habit of the vector.
• Scattered distribution of cases spread over large areas.
• Role of different reservoir hosts.
• Specific vectors for different geographical and ecological
areas.
• Immunization status of various population groups is not
known making it difficult to delineate vulnerable groups.