Strabismus & Amblyopia 
Alvina Pauline D. Santiago, MD 
Pediatric Ophthalmology & Strabismus 
Revised Dec 2014 ASMPH Y7
Anatomy of 
Extraocular Muscles 
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EOM Mechanisms 
! Actions of muscles 
! Ductions & Versions 
! Vergence movements: convergence, 
divergence 
! Hering’s & Sherrington’s laws 
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Orbital apex 
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Medial rectus 
www.wikipedia.org 
adduction
Lateral rectus 
www.wikipedia.org 
abduction
Inferior rectus 
! depressor 
! adducts 
! excyclotorsion 
www.wikipedia.org
Superior rectus 
! elevates 
! adducts 
! incyclotorts 
www.wikipedia.org
Superior oblique 
! incyclotorts 
! depresses 
! abducts 
www.wikipedia.org
Inferior oblique 
! excyclotorts 
! elevates 
! abducts 
www.wikipedia.org
EOM Movements 
! Duction: rotation from one eye 
! Versions: movement of both eyes from 
primary position (straight) to secondary 
position 
! Vergence: simultaneous ocular 
movements 
! convergence: nucleus of Perlia (midbrain) 
! divergence: midbrain near acoustic nerve nucleus 
08 January 2010 ASMPH Y7
Ocular Motility
Laws of Ocular Motility 
! Hering’s law of equal innervation 
! explains conjugate eye movements 
! Yoke muscles receive equal innervation 
! Sherrington’s law of reciprocal innervation 
! concerned with coordination of muscle pairs of one eye 
! when agonist contracts, there is inhibition of its direct antagonist 
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Yoke muscles: Hering’s Law 
RLR 
LMR 
RMR 
LLR 
RSR 
LIO 
RIR 
LSO 
RIO 
LSR 
RSO 
LIR
Antagonist Muscles: Sherrington’s Law 
RSR 
(-) RIR 
RLR 
(-) RMR 
RIR 
(-) RSR 
RIO 
(-) RSO 
RMR 
(-) RLR 
RSO 
(-) RIO
Vision Assessment 
Preverbal Age Group 
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Visual acuity testing 
• Evaluating fixation and preference 
• Using Allen cards or other preverbal test 
charts 
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Visual milestones 
• Birth Bright lights 
• 7 days vestibulo-ocular reflex 
• 3 mos transient FF 
• 6 mos FF even for distance 
• 2-3 y 20/30 
• 5-7 y 20/20 
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Vision Assessment 
• Fixation pattern 
• 3 mos: transient fix and follow 
• 6 mos: fix and follow 
– “CSM” nomenclature 
– cover one eye 
– start distance fixation 
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Fixation preference 
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Fixation Preference 
Son: Left Left Left None 
TEXT TEXT TEXT TEXT 
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Profound Amblyopia 
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Fixation Preference & 
Visual Acuity 
• Central, steady, maintained 
CSM 20/20-20/30 
• CS, maintained briefly 20/40-20/60 
• CS, not maintained (NM)20/70-20/80 
• C, NS, NM 20/100-20/200 
• Not C, Eccentric </= 20/300 
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Vision Assessment 
Non/Pre Verbal 
OKN Drum OKN Flag FPL Teller 
08 January 2010 ASMPH Y7
Visual Acuity Testing 
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• Test Charts 
– HOTV / HOTEX 
– “E” Game 
– Landolt C 
– Picture Charts
Vision Assessment 
Picture Charts HOTV SNELLEN 
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Strabismus Testing 
Tests of Ocular Alignment 
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Motor Testing 
• Ocular rotations 
• Measuring the deviation 
• Anomalous head posture 
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Ocular Rotations 
• Duction: monocular 
• Version: binocular 
• Hering’s law 
• Sherrington’s law 
• Alert to pattern deviations: e.g., A, V 
• Grading scheme: 
– e.g., inferior oblique & superior oblique 
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Ocular Motility Evaluation 
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RLR 
LMR 
RMR 
LLR 
RSR 
LIO 
RIR 
LSO 
RIO 
LSR 
RSO 
LIR
Ocular Rotations: Yoke muscles 
Cardinal gaze positions 
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RLR 
LMR 
RMR 
LLR 
RSR 
LIO 
RIR 
LSO 
RIO 
LSR 
RSO 
LIR
(L) Inferior oblique dysfunction 
+4 +1 
-4 -1 
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(R) Superior oblique 
dysfunction 
+4 +1 
-4 -1 
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Ocular misalignment 
• Hirschberg’s light reflex test 
• Bruckner’s red orange reflex test 
• Alternate prism cover test 
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Hirschberg’s Corneal Reflex 
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Hirschberg’s Corneal Reflex 
Mom: straight 
Son: RET RET RXT PseudoET 
TEXT TEXT TEXT TEXT 
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Pseudostrabismus 
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Head posture, Anomalous? 
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Anomalous head posture 
• Measure in non 
preferred head 
posture 
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Motor Testing 
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• Light reflex tests 
• Cover tests 
• Other tests 
– wear correction 
– no prisms
Motor Testing: Light Reflex Tests 
• Bruckner test 
• Hirschberg light reflex 
• Krimsky/modified Krimsky 
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Bruckner Test 
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® Ametropia 
® strabismus
Hirschberg’s Light Reflex 
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• 3.5 mm pupil: 
– 15 degrees at pupil 
edge 
– 30 degrees between 
limbus and edge of 
pupil 
– 45 degrees at limbus
Krimsky vs Modified Krimsky 
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– in front of deviating 
eye (modified 
Krimsky) 
– underestimates 
true angle 
– better at near
Motor Testing: Cover Tests 
• Primary gaze 
• Right and left gaze 
• Up and down gaze 
• Right and left head tilt 
• Near: primary and down gaze 
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Cover Tests 
• Requirements: 
– appropriate correction 
– no prisms vs. prisms 
– accommodative target 
– distance: 
• 6 m: 1/8 D of accommodation 
• > 6 m: X(T) 
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Techniques in Finding Strabismus 
• Bruckner test 
• Spielmann 
translucent occluder 
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(L) Superior oblique palsy 
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Direct Ophthalmoscope View: 
Fundus Torsion 
Excyclorotation Incyclorotation 
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Paralytic Exotropia:III nerve palsy 
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Inferior oblique dysfunction 
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Bruckner (Red Orange Reflex) 
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Amblyopia 
Pediatric Eye Disease Investigator Group 
(PEDIG) 
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Thank You! 
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2014 asmph strabismus & amblyopia