This document discusses topology optimization applied to automotive chassis design for weight reduction. Two chassis types are optimized - one for a spider vehicle and one for a coupé vehicle. The optimization minimizes mass subject to constraints for bending/torsional stiffness, crashworthiness, natural frequencies, and local joint stiffness. Six test cases are considered that incrementally add more constraints. Results show the optimized chassis masses decrease as more constraints are included. The optimized layouts provide innovative, efficient designs for lightweight automotive chassis.