The document discusses the role of a biomedical informationist at the National Institutes of Health Library. It describes how the informationist utilizes bioinformatics tools to explore relationships between genes, proteins, pathways, and diseases. Specifically, the informationist focuses on mining text and data to obtain information on gene function, metabolic pathways, and signaling pathways. The informationist also conducts sequence analysis, phylogenetic analysis, and protein structure analysis to understand protein interactions from the sequence level to 3D modeling.

1. Explorations in bioinformatics Division of Computational Biosciences Douglas James Joubert, MLIS Biomedical Informationist National Institutes of Health Library May 10, 2006

3. Bioinformatics is multi-faceted

4. Bioinformatics – My Approach

5. Bioinformatics – My Approach Formal and informal educational opportunities MS in bioinformatics NIH SIGs ACM & IEEE SIGs AMIA Working Groups

6. Bioinformatics – My Approach Formal and informal educational opportunities MS in bioinformatics NIH SIGs … Talk the talk

7. What is “Familiar” About MSCL – Informationist Collaboration Primary role is data and text mining Evaluate resources - resources typically text mining tools and database interfaces Conduct searches, subject terms are gene sets and microarray probe IDs; methods of database access are unique

8. What is Unique About MSCL – Informationist Collaboration MSCL does not use “library resources” in the traditional sense of the word 50% work commitment in lab Office space @ DCB, access to the NIH mainframe through HELIX MSCL collaborative efforts are intermittent, and project bound MSCL has been working with some core groups for 5+ years

9. Primary Roles with MSL Genes & Proteins Sequence Analysis Intermolecular & Biological Pathways Data and Text Mining

10. Genes & Proteins Roles linked to a clear vision MSCL DLS Sequence Analysis Intermolecular & Biological Pathways Data and Text Mining

11. What Tools do I use? Use bioinformatics tools to explore modeled relationships between proteins, genes, complexes, cells, tissues, drugs, and diseases Focus on information about gene function, metabolic, signaling, and canonical pathways

12. Sequence Analysis

13. subject terms Sequence Analysis

14. Phylogenetic Analysis Origins of a genetic disease At sequence level looking for unique and non-unique characters S. Wain-Hobson. (1998). 1959 and all that Nature 391: 531-532.

15. Protein Structure Analysis and Protein-Protein Interactions Field of structural biology Moving from Sequence to 3-D modeling Good tutorial available at: http://www.usm.maine.edu/~rhodes/SPVTut/

16. Pathway Analysis

17. Contact Information Douglas J. Joubert, MLIS Biomedical Informationist National Institutes of Health Library Bldg. 10, Room 1L09A Bethesda, MD 20906-1150 Phone: 301.594.6282 E-mail: joubertd@ors.od.nih.gov E-mail: joubertd@helix.nih.gov