The document discusses microarray studies to analyze gene expression. It provides background on the history and evolution of cDNA microarrays. It then describes the basic process of building microarray chips, preparing RNA samples, hybridizing chips, and analyzing data. Specific details are given on preparing probes, synthesizing oligonucleotides, making microarray chips in the lab, obtaining tissue samples, and analyzing emission from hybridized chips. The overall aim is to induce rupture of atherosclerotic plaques in mice and use microarrays to find genes expressed in ruptured plaques by comparing results to histopathology. Various drugs being tested to induce rupture are also listed.