The document discusses vulnerable plaque and challenges in detecting and treating it. It describes various imaging techniques for detecting vulnerable plaque such as thermography, MRI, CT angiography, and optical coherence tomography. However, it notes that while these can identify high-risk features, it remains unclear what exactly defines vulnerable plaque and whether imaging findings truly correlate with risk. The document also notes that while statins reduce events, the relationship between plaque burden and events is unclear, and better defining and detecting the disease is still needed before new therapies can be developed.
Cardiovascularprevention.con is a website for prevention of cardiovascular disease. Heart attack, sudden death or stroke is the first sign of cardiovascular disease in one third of healthy people. In this slide presentation you can find our innovative methods for assesing the first sign of atherosclerosis and the managment of cardiovascular risk in healty individuals...and more.
Drs. Angela Pikus, Alex Blackwell, Mark Baumgarten, Rosa Malloy-Post are Emergency Medicine Residents and interested in medical education. With the guidance of Dr. Michael Gibbs, a notable Professor of Emergency Medicine, they aim to help augment our understanding of emergent imaging. Follow along with the EMGuideWire.com team as they post these educational, self-guided radiology slides. This set will cover:
• Abnormalities of the Thoracic Aorta
o Traumatic aortic disruption
o Thoracic aortic aneurysm with acute dissection
Coronary Calcium and other CVD Risk Biomarkers: From Epidemiology to Comparat...CTSI at UCSF
Presented by Philip Greenland, MD, at UCSF's symposium "The Role of Risk Stratification and Biomarkers in Prevention of Cardiovascular Disease" in Jan 2012.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
1. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Perspective:
Vulnerable Plaque
…or vessels, patients
or ??
Robert S. Schwartz, MD
Minneapolis Heart Institute
2. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
How to Cure Human Disease
1. Define the Disease
2.Associate it reliably
3.Find the Disease
4. Deliver the ‘Fix’
6. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
3 Autopsy Derived Groups
Acute MI
18 patients/337 segments
Stable Angina
5 Patients/76 segments
Controls (no CAD)
9 Patients/111 segments
Coronary
Inflammation
Is Diffuse
7. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Inflammatory Cell Count
Macrophages/Monocytes
CD-68 Positivity
T-Lymphocytes
CD-3 Positivity
Coronary
Inflammation
Is Diffuse
8. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
IRA
Segments
AMI
Non-IRA
segments
of AMI group
Controls
CD68 positive cells
monocytes/macrophag
es
38.0
+ 7.9%
35.3
+ 4.7%
1.0
+ 2.9%
CD3 positive cells
(T-lymphocytes)
17.7
+ 3.5%
20.9
+ 4.1%
7.6
+ 1.6%
Coronary Artery Inflammation Is Diffuse
JACC April 2005 Mauriello, Sangiorgi, Fratoni, Palmieri, Bonanno, Anemona Schwartz, Spagnoli
9. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Coronary Inflammation Is Diffuse
0
5
10
15
20
25
30
35
40
IRA Non-IRA Control
Macrophages Lymphocytes
JACC April 2005 Mauriello, Sangiorgi, Fratoni, Palmieri, Bonanno, Anemona Schwartz, Spagnoli
11. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Thermography
Will Thermography will
easily detect and localize
vulnerable plaque?
13. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Porcine Proximal LCX
10 days
Histopathology:
Chronic, superficial inflammation,
mainly mononuclear cells
¾ of the lumen circumflex
Temperature:
Circumferential and significantly increased
vessel wall temperature above 1.0°C
14. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Caveat:
Thermography and thermal
heterogeneity measures
appear highly flow
dependent. The methods
and devices can be
technically challenging.
Major differences exist
across published studies.
16. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Self-contained
portable MRI
catheter
Catheter Based MRI Imaging
17. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Ex-vivo MR imaging: human coronary arteries
Adaptive intimal
thickening
LAD atheroma
20. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Coronary Ruptured Plaque (CTA)
Aortic Penetrating Ulcer (MRA)
21. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Is Not ‘Soft Plaque”
MSCTA visualizes well
Questions:
Prevalence of isolated Uncalcified Plaque (no
associated calcified plaque)
Risk Factors associated
CTA and Uncalcified Plaque
22. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
506 unselected patients scanned for chest pain
16-Slice MSCTA
CTA and Uncalcified Plaque
23. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
30% (124/506 patients) had no calcification
CTA and Uncalcified Plaque
30%
70%
No Calcification
Calcification
24. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
44% (55/124 patients) had no plaque
CTA and Uncalcified Plaque
30%
70%
No Calcification
Calcification
25. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
51% (63/124patients) had uncalcified plaque
without severe stenosis
CTA and Uncalcified Plaque
51%
49%
No Stenosis
Stenosis
26. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
5% (6/124 patients) of Uncalcified Plaque had
significant stenosis
CTA and Uncalcified Plaque
5%
95%
Significant
Stenosis
No Signficiant
Stenosis
27. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Risk Factors and all uncalcified plaque
83% Smokers (former/current)
98% of patients with 0-3 Risk factors had no plaque or
<50% Stenosis
86% of patients with > 4 Risk factors had UCP and/or
significant stenosis
No patient with <2 Risk Factors had uncalcified
plaque
28. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Uncalcified plaque is prevalent in patients with chest
pain
Smoking may have significant impact on UCP
formation.
UCP prevalence is highly dependent on aggregate
coronary risk.
MSCTA appears useful for detecting both calcified
and noncalcified coronary plaque.
MSCTA and Uncalcified Plaque
29. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Observation:
Significant technical
developments are needed
for MRI. Problems of
Spatial and Temporal
Resolution, and Acquistion
remain a major
impediment to clinical
coronary imaging in living
patients.
31. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Culprit
Lesion
M-OA
M-LC
A-WJ
Unstable
E-KK M-UM
E-IM E-JS
A-MK
RECENT MI
UNSTABLE ANGINA
UNSTABLE ANGINA
Just proximal to
stented lesion
32. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Caveat
Intravascular Imaging
can localize thin-cap
fibroadenoma and lipid-
laden regions of
vulnerability.
But what does it mean?
33. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Raman Spectroscop
Scepanvic O, Galindo LH, Feld MS
34. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Now that we aren’t certain about diagnoses,
what about therapy?
Perspective: Imaging Vulnerable Plaque
35. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
%%
withwith
EvenEven
tt
00 33 1818 2121 2424 2727 303066 99 1212 1515
2020
1515
1010
55
00
Months of Follow-up
All-Cause Death, Non-Fatal MI, or
Urgent Revascularization
Pravastatin 40mgPravastatin 40mg
16.7%16.7%
Atorvastatin 80mgAtorvastatin 80mg
12.9%12.9%
25% RR25% RR
P = 0.0004P = 0.0004
36. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
16.7
20.5
33.3
16.7
6.4
3.9
1.3 1.3
0 0 0 0 0
0
5
10
15
20
25
30
35
Percent(%)
10
20
30
40
50
60
70
80
90
100
110
120
130
millimeters (mm)
Prox Mid Distal
p = 0.003
Distribution of Acute Coronary Occlusions
Left Anterior Descending Artery
(Normalized Segment Analysis)
37. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
0
10
20
30
40
50
60
70
80
90
100 0
10
20
30
40
50
60
70
80
90
100
110
120
130
millimeters (mm)
Percent(%)Acute Coronary Occlusions by Distance from
Left Anterior Descending Artery Ostium
38. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
How to Cure Human Disease
1. Define the Disease
Not Yet
2.Associate it reliably
Not Yet
3.Find the Disease
Not Yet
4. Deliver the ‘Fix’
Not Yet
39. The Minneapolis Heart
Institute Foundation
The Minneapolis
Heart Institute
Perspective:
Vulnerable Plaque
…or vessels, patients
or ??
Robert S. Schwartz, MD
Minneapolis Heart Institute
Editor's Notes
&lt;number&gt;
So, given the impact that stents have on the vascular system, it is critical that the body’s response to this injury is in the form of controlled, healthy healing.
A few things to consider when evaluating DES are:
- The ability for certain compounds, such as paclitaxel, to selectively target smooth muscle cells at lower doses than endothelial cells, thereby allowing for endothelial cells to grow over the stent struts to create a slippery surface that is non-thrombogenic may be important.
- While controlling late loss is important, it may be equally important that there is a degree of consistency across trials and patient subsets. While achieving zero millimeters of late loss intuitively seems favorable, such a condition may not be conducive to healing.
- The presence of late incomplete apposition is of concern because blood may be able to flow behind the stent struts, which may lead to a complications.
- One of the important follow-up measurements in clinical trials is the progression of incomplete apposition. Gaps that form behind struts or increase in size can potentially cause blood to pool and clots to form (thrombus)
&lt;number&gt;
There are only a handful of radioisotopes with characteristics suitable for coronary Brachytherapy applications. Radioactive isotopes have a fixed half-life (the time it takes for the activity to drop by half). Their energies are also fixed.
These energies are dictated by the nuclear structure and cannot be altered. Therefore to reach a certain target with radioisotopes one must have the right energy. If the conditions between the isotope and the target are changed by the presence of foreign material with different properties than tissue the dose to the target may not be achieved.
As I mentioned earlier, beta sources have a limited depth of penetration which is adequate for a millimeter depth. On the other hand due to gamma&apos;s penetrating power it delivers a dose well beyond the treatment zone.
&lt;number&gt;
So, given the impact that stents have on the vascular system, it is critical that the body’s response to this injury is in the form of controlled, healthy healing.
A few things to consider when evaluating DES are:
- The ability for certain compounds, such as paclitaxel, to selectively target smooth muscle cells at lower doses than endothelial cells, thereby allowing for endothelial cells to grow over the stent struts to create a slippery surface that is non-thrombogenic may be important.
- While controlling late loss is important, it may be equally important that there is a degree of consistency across trials and patient subsets. While achieving zero millimeters of late loss intuitively seems favorable, such a condition may not be conducive to healing.
- The presence of late incomplete apposition is of concern because blood may be able to flow behind the stent struts, which may lead to a complications.
- One of the important follow-up measurements in clinical trials is the progression of incomplete apposition. Gaps that form behind struts or increase in size can potentially cause blood to pool and clots to form (thrombus)
&lt;number&gt;
There are only a handful of radioisotopes with characteristics suitable for coronary Brachytherapy applications. Radioactive isotopes have a fixed half-life (the time it takes for the activity to drop by half). Their energies are also fixed.
These energies are dictated by the nuclear structure and cannot be altered. Therefore to reach a certain target with radioisotopes one must have the right energy. If the conditions between the isotope and the target are changed by the presence of foreign material with different properties than tissue the dose to the target may not be achieved.
As I mentioned earlier, beta sources have a limited depth of penetration which is adequate for a millimeter depth. On the other hand due to gamma&apos;s penetrating power it delivers a dose well beyond the treatment zone.
&lt;number&gt;
There are only a handful of radioisotopes with characteristics suitable for coronary Brachytherapy applications. Radioactive isotopes have a fixed half-life (the time it takes for the activity to drop by half). Their energies are also fixed.
These energies are dictated by the nuclear structure and cannot be altered. Therefore to reach a certain target with radioisotopes one must have the right energy. If the conditions between the isotope and the target are changed by the presence of foreign material with different properties than tissue the dose to the target may not be achieved.
As I mentioned earlier, beta sources have a limited depth of penetration which is adequate for a millimeter depth. On the other hand due to gamma&apos;s penetrating power it delivers a dose well beyond the treatment zone.
&lt;number&gt;
There are only a handful of radioisotopes with characteristics suitable for coronary Brachytherapy applications. Radioactive isotopes have a fixed half-life (the time it takes for the activity to drop by half). Their energies are also fixed.
These energies are dictated by the nuclear structure and cannot be altered. Therefore to reach a certain target with radioisotopes one must have the right energy. If the conditions between the isotope and the target are changed by the presence of foreign material with different properties than tissue the dose to the target may not be achieved.
As I mentioned earlier, beta sources have a limited depth of penetration which is adequate for a millimeter depth. On the other hand due to gamma&apos;s penetrating power it delivers a dose well beyond the treatment zone.
&lt;number&gt;
There are only a handful of radioisotopes with characteristics suitable for coronary Brachytherapy applications. Radioactive isotopes have a fixed half-life (the time it takes for the activity to drop by half). Their energies are also fixed.
These energies are dictated by the nuclear structure and cannot be altered. Therefore to reach a certain target with radioisotopes one must have the right energy. If the conditions between the isotope and the target are changed by the presence of foreign material with different properties than tissue the dose to the target may not be achieved.
As I mentioned earlier, beta sources have a limited depth of penetration which is adequate for a millimeter depth. On the other hand due to gamma&apos;s penetrating power it delivers a dose well beyond the treatment zone.
&lt;number&gt;
There are only a handful of radioisotopes with characteristics suitable for coronary Brachytherapy applications. Radioactive isotopes have a fixed half-life (the time it takes for the activity to drop by half). Their energies are also fixed.
These energies are dictated by the nuclear structure and cannot be altered. Therefore to reach a certain target with radioisotopes one must have the right energy. If the conditions between the isotope and the target are changed by the presence of foreign material with different properties than tissue the dose to the target may not be achieved.
As I mentioned earlier, beta sources have a limited depth of penetration which is adequate for a millimeter depth. On the other hand due to gamma&apos;s penetrating power it delivers a dose well beyond the treatment zone.
&lt;number&gt;
There are only a handful of radioisotopes with characteristics suitable for coronary Brachytherapy applications. Radioactive isotopes have a fixed half-life (the time it takes for the activity to drop by half). Their energies are also fixed.
These energies are dictated by the nuclear structure and cannot be altered. Therefore to reach a certain target with radioisotopes one must have the right energy. If the conditions between the isotope and the target are changed by the presence of foreign material with different properties than tissue the dose to the target may not be achieved.
As I mentioned earlier, beta sources have a limited depth of penetration which is adequate for a millimeter depth. On the other hand due to gamma&apos;s penetrating power it delivers a dose well beyond the treatment zone.
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So, given the impact that stents have on the vascular system, it is critical that the body’s response to this injury is in the form of controlled, healthy healing.
A few things to consider when evaluating DES are:
- The ability for certain compounds, such as paclitaxel, to selectively target smooth muscle cells at lower doses than endothelial cells, thereby allowing for endothelial cells to grow over the stent struts to create a slippery surface that is non-thrombogenic may be important.
- While controlling late loss is important, it may be equally important that there is a degree of consistency across trials and patient subsets. While achieving zero millimeters of late loss intuitively seems favorable, such a condition may not be conducive to healing.
- The presence of late incomplete apposition is of concern because blood may be able to flow behind the stent struts, which may lead to a complications.
- One of the important follow-up measurements in clinical trials is the progression of incomplete apposition. Gaps that form behind struts or increase in size can potentially cause blood to pool and clots to form (thrombus)