SHAPE Society

1. © 2002 Slide 1
Trans-Blood Vision™ Possibilities
for Vulnerable Plaque
A Presentation for the
3rd
Annual
Vulnerable Plaque Symposium
March 16, 2002

2. © 2002 Slide 2
Seeing Through Blood
The technique is adapted from military methods to see through
smoke, mist, fog, etc.
SWIR WavelengthVisible Wavelengths
For example, the following satellite photos of a section of the
Oahu coastline illustrate how mist and haze seen at visible
wavelengths disappear when viewed in the Short Wave IR band.
Trans-Blood Vision™ is a patented infrared
technique to see directly through blood.

3. © 2002 Slide 3
System Illustration
Monitor – already in place
CardioOptics IR Instrument:
- IR illumination source
- IR video camera
IR interconnect cable
Sterile, disposable
IR fiberoptic catheter:

4. © 2002 Slide 4
• Looking directly through flowing
blood in a live animal
• Clip begins with exploration of
bifurcation in the portal vein
system & ends with canulation
of selected branch
• Raw, unprocessed video.
Black & white presentation.
Video Clip: Endocardial Imaging
of IVC-Portal Vein System
1
2
To Heart
(Inferior Vena Cava)
Portal
Vein
System
Caudal
Vein

5. © 2002 Slide 5
Video Clip of Vein Bifurcation
Unprocessed proof of concept video taken through flowing blood.

6. © 2002 Slide 6
Comments
• Structures appear as if viewed through water
• High degree of reflectivity from tissue surfaces
• No video enhancement techniques have yet been
applied, which will dramatically improve images.

7. © 2002 Slide 7
Augmentative Technologies
o Dimensional measurement: The ability to quantitatively
measure the size of structures visualized. This includes
granularity and surface feature detail assessment.
o Tissue/material characterization: The ability to provide the
clinician with information about the nature of the structure in the
TBV™ view (e.g., detection of calcification, presence of lipids).
o Real-time motion analysis: The ability to perform real-time
dynamic elastic properties assessment.
o Membrane penetration: The ability to determine tissue/material
characterization below the surface of membranes associated with
Vulnerable Plaque lesions.
Note: The following are extensions of Trans-Blood Vision ™.
They have been theorized, tested to some degree in vitro, but not
yet tested in vivo or on Vulnerable Plaque lesions.

8. © 2002 Slide 8
Vulnerable Plaque Potential
 Find lesions without first entering them (forward view)
 Determine size & surface characteristics in high resolution
 Look at material constituents, both on and below the
surface (within limited IR wavelengths)
 Perform dynamic elastic velocity profiles in real time
But not:
 Provide direct visual guidance for therapy
 Penetrate deeply like ultrasound
Combining Trans-Blood Vision™ with these promising
augmentative technologies provides the potential to
simultaneously in real-time:
 Measure lesion temperature (though a temperature
probe could be visually guided)

9. © 2002 Slide 9
Conclusion:
Trans-Blood Vision™ has sufficient potential to
provide a platform for real-time, simultaneous,
multi-mode Vulnerable Plaque lesion detection,
analysis, and therapy guidance that it warrants
significant investigation, possibly in
combination with other technologies currently
under development.

10. © 2002 Slide 9
Conclusion:
Trans-Blood Vision™ has sufficient potential to
provide a platform for real-time, simultaneous,
multi-mode Vulnerable Plaque lesion detection,
analysis, and therapy guidance that it warrants
significant investigation, possibly in
combination with other technologies currently
under development.