Patient P.V., a 74-year-old male, presented with progressive body weakness that began 15 days prior. He reported weakness starting in his lower extremities and progressing upwards. He was admitted to the hospital with a chief complaint of body weakness and a diagnosis of Guillain-Barré syndrome was considered. Guillain-Barré syndrome is an autoimmune disorder where the body's immune system attacks the peripheral nervous system, causing muscle weakness and possible paralysis. Nursing care involved assessing the patient, administering medications to treat the condition, providing respiratory support if needed, and patient/family education on Guillain-Barré syndrome and its management.