1. Drugs Classification Mechanism of action Indication Contraindication Adverse effect Nursing intervention
& precaution
Generic name:
Ceftazidime
Brand name:
Tazidim
Dosage:
300 mg
Route:
IVTT
Frequency:
Q 8 hour
ANST (-)
Antibiotic
Cephalosporin ( third
generation)
Inhibits synthesis of
bacterial cell wall,
causing cell death.
CNS infections Contraindicated to
patients with allergies
to penicillin,
cephalosporin
CNS: headache,
dizziness, lethargies,
paresthesis.
GI: nausea, vomiting,
abdominal pain,
anorexia,
pseudomembranenous
colitis, liver toxicity.
GU: nephrotoxicity
Hematologic: bone
marrow depression –
decreased WBC,
decreased platelets,
Decreased Hct.
Hypersensitivity:
ranging from rash to
fever to anaphylaxis,
serum sickness
reaction.
Local: pain, abscess at
injection site, phlebitis,
inflammation at IV site.
Others: superinfections
disolfram – like
reactions with alcohol
Assess for liver and
renal dysfunction
Culture infection and
arrange sensitivity test
before and during
therapy if expected
response is not seen.
Warning:
Do not mix with
aminoglycosides
solutions, administer
these drugs separately
Powder and
reconstituted solution
darken when storage
Have vit K available in
case
hypoprothrombinemia
occurs
Discontinue if
hypersensitivity occurs
Teach SO that patients
may experience upset
stomach or diarrhea
but must report severe
diarrhea, difficulty of
breathing, fatigue, pain
at injection site.