A 23-year-old man collapsed within 2 minutes of receiving a long-acting penicillin injection, exhibiting symptoms of acute anaphylaxis including urticaria, erythema, pruritus, excessive tearing, coughing, abdominal pain, nausea, vomiting and diarrhea. Epinephrine is the drug of choice for treating anaphylactic shock, as it is effective for shock, angioedema, airway obstruction and bronchospasm. General measures for treatment of anaphylaxis include assessing airway and vital signs, administering oxygen, and positioning the patient upright.