This document provides an overview of Wilson disease, including its epidemiology, genetics, pathophysiology, clinical features, diagnosis, and treatment. Key points include: - Wilson disease is an autosomal recessive disorder caused by mutations in the ATP7B gene resulting in copper accumulation. - It occurs worldwide with an incidence of 1 in 30,000. Symptoms typically onset between ages 6-40. - Clinical presentation can include hepatic, neurological, and psychiatric features. Kayser-Fleischer rings seen on eye exam and low ceruloplasmin levels support diagnosis. - Treatment involves chelation therapy with penicillamine or trientine to remove excess copper from the body. Zinc can also