This document analyzes and designs high-rise buildings with vertical irregularities located in seismic zone III. It summarizes the analysis of 4 irregular building types using ETABS software to study the effects of mass irregularities, soft stories, and setbacks. The analysis found that buildings combining soft stories and mass irregularities (IT01 type) experienced the largest story displacements, drifts, and shears, indicating this combination reduces seismic performance the most. In general, performance decreased in the order of IT01, IT04, regular building, IT02, IT03. The study concludes vertical irregularities like soft stories and mass variations can endanger buildings during earthquakes by interacting to decrease lateral stiffness.