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4. Anomalies of face
Def ect s of rhomboencephalic organizing cent er,
account f or dysmorphology of middle & lower 3rd
of
f ace.
Facial clefts
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6. Prenatal development
Palate
Format ion of primary and secondary palat e
Elevat ion of palat al shelves
Fusion of palat al shelves
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7. Intermaxillary segment
Formed by mer ging of t he 2 medial nasal
pr ocesses
I t is composed of –
a) Labial component - f orms PHI LTRUM
b) Upper j aw component - carries 4 MAX.I NCI SORS
c) Palat al component - f orms PRI MARY PALATE
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8. Primary palate
Front onasal process
Medial nasal
Mesenchyme
Wedge shaped mass
bet ween int ernal
surf ace of maxillar y
prominence
Primary palat e
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9. Secondary palate
6th
week– 2 lat eral palat al shelves develops
Secondary nasal sept um grows
7th
week– palat al shelves grow & lie vert ically
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10. 8th
week IUL
St omodeum enlarges
Tongue drops
Vert ically inclined palat al shelves -horizont al
Shelves cont act each ot her in midline
By 12th
week, f usion of palat al processes is complet e
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11. To summarize…
Maxillary prominence
2 horizont al mesenchymal proj ect ions
6t h
week Lat eral palat ine process
Fuse-
Wit h each ot her -12t h
week
Primary palat e
Nasal sept um
Secondary palat e
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13. Elevation of palatal shelves-8th
Elevat ion of palat al shelves
Muscular
movement
Pressure
dif f erences
Biomechanical
t ransf ormat ion of
connect ive t issue
mat rix
I nt rinsic
shelf f orce
Dif f erent ial
mit ot ic growt h
Wit hdrawal of
embryo’s f ace
Vascular
changes
I ncrease in t issue
Tur ger
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14. Theories of palatal shelf elevation
EXTRINSIC FORCES
Descent of t ongue
Myoneural act ivit y wit h in t ongue
Shelves pushed up by t ongue
Mout h opening ref lexes
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15. Theories of palatal shelf elevation
INTRINSICFORCES
Hydr at ion and polymerisat ion of int ercellular subst ance
Dif f erent ial growt h on one side of palat al shelf
Turgor produced by build up of HYALURONI C ACI D
SEROTONI N release f r om neural t issue.
Mesenchymal cell biosynt het ic act ivit y
Changing amount s of GLYCOSAMI NOGLYCANS(GAG)
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18. Ossification of palate
8t h
wk
10t h
wk
Childhood
12- 14
years
Premaxillary cent res
Primary ossif icat ion cent res of each palat ine bone
Y shaped midpalat al sut ure
T shaped midpalat al sut ure
No ossif icat ion at t he sof t palat e region
Mid palat ine sut ure ossif ies
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19. Growth in dimensions-palate
Pre nat al lif e (apposit ional growt h in t he
alveolar margin)
lengt h > widt h
At birt h (apposit ional growt h in t he maxillary
t uberosit y)
lengt h = widt h
Post nat al lif e
widt h > lengt h
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20. Growth in dimensions-palate
Lengt h increases - 7-18 weeks I UL
Widt h increases - 4th
mont h onwards
height
widt h
lengt h
Arched palat e
Lat eral alveolar process t oget her wit h a concave
f loor produced by t ongue – palat al t unnel t o
receive a nipple
Thumb and f inger sucking- accent uat ed palat al
f urrow
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22. Anomalies of palate
28t h – 38t h day – Primary palat e Clef t lip
&/ or palat e and ot her Facial Clef t s
42nd -55t h day – Secondary palat e Clef t
palat e
Shelf elevat ion and f usion begins earlier in
males- account ing sex dif f erences in incidence.
5 TH
week
I UL
12 TH
week I UL6 9
CRITICALPERIOD
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23. Palatal clefts
Def ect ive f usion of various component s of palat e
Causes:
Def ect ive shelf f usion
Failure of shelves t o elevat e
Failure of t ongue t o drop f rom b/ w shelves
Smallness of shelves
I nhibit ion of f usion process it self
Delayed elevat ion of shelves
Failure of medial edge epit helial cell deat h
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