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Lecture Series on
  Biostatistics

                     No. Biostat - 5
                    Date: 10.08.2008


 MEASURES OF MORTALITY
              Dr. Bijaya Bhusan Nanda,
          M. Sc (Gold Medalist) Ph. D. (Stat.)
     Topper Orissa Statistics & Economics Services, 1988
            bijayabnanda@yahoo.com
CONTENTS

   Introduction
   Determinants of Mortality
   Uses of Mortality data
   Sources of Mortality data
   Measures of Mortality
   Life Table
LEARNING OBJECTIVE


 They will be able to compute
  different indices of mortality.
 They will be able to spell out general

  determinants of mortality.
 They will be able to spell out

  usefulness of mortality indicators.
INTRODUCTION

Death:
  “the permanent disappearance of all evidences of
    life at any time after birth” (WHO).
• Mortality:
  • A demographic event – Average risk of dying of a
    person in the group during a time span.
  • This is one of the three determinants of
    population change i.e. fertility, mortality and
    migration.
• Factors of mortality patterns:
  • Endogenetics (biological):
  • Exogenetic(environmental):
DETERMINANTS OF MORTALITY

   Vary over Space and Time
Classified in to three categories:
Demographic structure- Age, Sex Composition etc.
Social advancement- Age at marriage, Adequacy of
  medical facilities, General condition of nutrition,
  Housing and Sanitation, Literacy, Religion, Caste
  and Community beliefs etc.
Economic development- Occupation, Standard of
  living/ per capita income , Type of economy etc.
USES OF MORTALITY RATE


 Useful for projecting the future size of the
  population
 Identify population groups that are at high risk
  and in need of health service
 Indicatives of quality of life and expectation of
  life at birth.
 Useful guides to planners
 Helpful to insurance companies
SOURCES OF MORTALITY DATA

      There are two sources:
I. Direct source
    Registration of vital events
    Sample Registration Surveys
    National Family Health Surveys
I. Indirect source
    Age data of two consecutive censuses may be
     used to estimates death rates
    Demographic year book: U.N. Publication
    World Health Organization (WHO) also
     provides data
MEASURES OF MORTALITY
 It is the quantitative and statistical devices
 to label the risk of mortality to which a
 population is exposed over a period of time.
 Different measures of mortality:-
 Crude death rate:
 Crude death rate (d) =( D/P)*1000
 D= No. of deaths in a population during a
 given calendar year
 P= average number of persons living in the
 population during the year
   Merits
      requires minimum data on mortality
      Easy to interpret
   Demerits
     Since the risk of death is not uniform
     for different segments of population
     (age, sex etc.) CDR is a crude measure
     and cant be used directly for comparing
     the levels of mortality in two or more
     countries.
Age Specific Death Rates(ASDR)

                                        Dx
Age specific death rate (ASDR) =nMx=   n
                                             × 1000
                                       n Px

nDx = No. of death between x and x+n in the yr.

nPx = No. of persons aged between x and x+n in
the middle of yr.
Note: Line graph of ASDR at y-axis and age at
x-axis it shows J-shape pattern for developed
countries and U-shape pattern for developing
countries because in developing countries
mortality rates are comparatively higher at
younger ages.
Infant Mortality Rate (IMR)

No. of infants dying under one year of age in a
year per thousand live birth in a given
geographical region.
               D0
     IMR=         × 1000
               B


D0 : No. of infants who died before celebrating
their first birthday.

B : Total No. live births occurring in that year
and geographical region.
Child Mortality Rate (CMR)
Defined as the total number of deaths of
children aged 1 to 4 yrs. per 1000 population
of the same age in a given year and
geographical region.
        No. of deaths of children aged 1to
        4 yr in given yr and region
CDR =                                        × 1000
          tot. population aged 1 to 4 in
         the given yr and a given region
Neonatal Mortality Rate (NMR):
   No. of infants dying within the first 4 weeks or up
   to 28 days of life per 1000 live birth in a year and
   geographical region.
              Deaths of infants up to 4 weeks
       NMR =                                    × 1000
                      No. of live births
Early Neonatal Mortality Rate (NMR):
    No. of infant deaths during the first seven days of
    life per 1000 live births in a year and geographical
    region.

ENMR = Deaths of infants in the first week of life
                                                     × 1000
                     No. of live births
Perinatal Mortality Rate (PMR)

No. of still births/ late foetal deaths (after 28
weeks of gestation) plus deaths within first
week of life in a year and geographical region
for 1000 births (live and still) in a year and
region.


    Foetal deaths after 28weeks of gestation +
    deaths of newborns within 7days
PMR=                                             × 1000
       No. of live births during the same year
Post Neonatal Mortality Rate (PNMR)


    Number of infants deaths after 28 days to
less than 1yr (between 4 weeks to 52 weeks)
of age per 1000 live births in a given year.


        No. of deaths of newborns between
        4weeks or less than 1yr old in a year
PNMR=                                        × 1000
         No. of live births during the same yr
Maternal Mortality Ratio (MMR)

 No. of deaths of women while pregnant or
 within 42 days of termination of pregnancy
 from any cause related to pregnancy/
 childbearing and child birth per 100,000 live
 births in a given year.
       Deaths of pregnant women and women
       after termination of pregnancy within 6
       weeks from any cause related to
       pregnancy
MMR=                                         × 100000
        No. of live births during the same year
Maternal Mortality Rate (MMRT)

Number of maternal deaths while pregnant
or within 42 days of termination of
pregnancy from any cause related to
pregnancy/ childbearing and childbirth per
100,000 women in reproductive ages 15-49.

           No. of maternal deaths of
             women in age 15-49
MMRT =                                 × 1000
           No. of women in age 15-49
                   in a given yr
    Foetal Death:
    Deaths prior to the complete expulsion or
    extraction from its mother of a product of
    conception at any time of pregnancy.
    Still Birth
    Death of foetus after completing 28 weeks and
    till the time of birth.
    Incidence Rate
    Number of NEW cases of specified diseases
    occurring in a defined population during a
    specified period of time.
(Continued…………)
                   No. of new cases of specified
                   disease during a given period
Incidence rate =                                       × 1000
                         Population at risk
   Prevalence Rate
   Number of all current cases (old and new) of a
   disease at one point in time in relation to defined
   population.     No. of new and old cases
                       of specified disease existing
                       at a given point in time
 Prevalence rate =                                       × 1000
                         Estimated population at
                         the same point in time
s
                                                         th
                                                                                ks of gestation completed




         Toddler     Post           Late       Early          Still Birth
          Death    Neonatal       Neonatal    Neonatal
                    Death          Death       Death
                                        Neonatal
                                         Death


                                                              Perinatal Death
                              Infant Death
Time Reference for Mortality in Childhood and Infancy
Limitations of Measures of Mortality


 The risk in a population may vary
  largely with various socio-economic
  and biological traits.
 The lack of reliable and requisite data

  presents serious problem sometimes of
  considerable magnitude.
Exercise: Calculate the crude and Age specific death
   rates of the population from the following data

 Age-group         Population          Deaths
  (Years)
   Under 10           20,000             600
    10-20             12,000             240
    20-40             50,000            1,250
    40-60             30,000            1,050

   Above 60           10,000             500
Expectation of Life
   The curate Expectation of life, (ex) gives the
    average number of completed years of life lived
    by the cohort l0 after age x by each of lx
    persons attaining that age. The complete
    expectation of life, denoted as exo, measures the
    average number of years a person of given age
    can be expected to live under the prevailing
    mortality conditions. It gives the number of
    years of life entirely completed and includes
    the fraction of the year survived in the year in
    which death occur, which on the average can
    be taken to be ½ years. exo = ex +1/2
REFERENCE
   An Introduction to the Study of
    Population, Bhaskar D. Mishra
   Techniques of demographic Analysis,
    K. B Pathak, F. Ram
   Fundamentals of Applied Statistics,
    S.C Gupta and V. K Kapoor.
THANK YOU

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Measures of mortality

  • 1. Lecture Series on Biostatistics No. Biostat - 5 Date: 10.08.2008 MEASURES OF MORTALITY Dr. Bijaya Bhusan Nanda, M. Sc (Gold Medalist) Ph. D. (Stat.) Topper Orissa Statistics & Economics Services, 1988 bijayabnanda@yahoo.com
  • 2. CONTENTS  Introduction  Determinants of Mortality  Uses of Mortality data  Sources of Mortality data  Measures of Mortality  Life Table
  • 3. LEARNING OBJECTIVE  They will be able to compute different indices of mortality.  They will be able to spell out general determinants of mortality.  They will be able to spell out usefulness of mortality indicators.
  • 4. INTRODUCTION Death: “the permanent disappearance of all evidences of life at any time after birth” (WHO). • Mortality: • A demographic event – Average risk of dying of a person in the group during a time span. • This is one of the three determinants of population change i.e. fertility, mortality and migration. • Factors of mortality patterns: • Endogenetics (biological): • Exogenetic(environmental):
  • 5. DETERMINANTS OF MORTALITY  Vary over Space and Time Classified in to three categories: Demographic structure- Age, Sex Composition etc. Social advancement- Age at marriage, Adequacy of medical facilities, General condition of nutrition, Housing and Sanitation, Literacy, Religion, Caste and Community beliefs etc. Economic development- Occupation, Standard of living/ per capita income , Type of economy etc.
  • 6. USES OF MORTALITY RATE  Useful for projecting the future size of the population  Identify population groups that are at high risk and in need of health service  Indicatives of quality of life and expectation of life at birth.  Useful guides to planners  Helpful to insurance companies
  • 7. SOURCES OF MORTALITY DATA There are two sources: I. Direct source  Registration of vital events  Sample Registration Surveys  National Family Health Surveys I. Indirect source  Age data of two consecutive censuses may be used to estimates death rates  Demographic year book: U.N. Publication  World Health Organization (WHO) also provides data
  • 8. MEASURES OF MORTALITY  It is the quantitative and statistical devices to label the risk of mortality to which a population is exposed over a period of time. Different measures of mortality:-  Crude death rate: Crude death rate (d) =( D/P)*1000 D= No. of deaths in a population during a given calendar year P= average number of persons living in the population during the year
  • 9. Merits  requires minimum data on mortality  Easy to interpret  Demerits  Since the risk of death is not uniform for different segments of population (age, sex etc.) CDR is a crude measure and cant be used directly for comparing the levels of mortality in two or more countries.
  • 10. Age Specific Death Rates(ASDR) Dx Age specific death rate (ASDR) =nMx= n × 1000 n Px nDx = No. of death between x and x+n in the yr. nPx = No. of persons aged between x and x+n in the middle of yr. Note: Line graph of ASDR at y-axis and age at x-axis it shows J-shape pattern for developed countries and U-shape pattern for developing countries because in developing countries mortality rates are comparatively higher at younger ages.
  • 11. Infant Mortality Rate (IMR) No. of infants dying under one year of age in a year per thousand live birth in a given geographical region. D0 IMR= × 1000 B D0 : No. of infants who died before celebrating their first birthday. B : Total No. live births occurring in that year and geographical region.
  • 12. Child Mortality Rate (CMR) Defined as the total number of deaths of children aged 1 to 4 yrs. per 1000 population of the same age in a given year and geographical region. No. of deaths of children aged 1to 4 yr in given yr and region CDR = × 1000 tot. population aged 1 to 4 in the given yr and a given region
  • 13. Neonatal Mortality Rate (NMR): No. of infants dying within the first 4 weeks or up to 28 days of life per 1000 live birth in a year and geographical region. Deaths of infants up to 4 weeks NMR = × 1000 No. of live births Early Neonatal Mortality Rate (NMR): No. of infant deaths during the first seven days of life per 1000 live births in a year and geographical region. ENMR = Deaths of infants in the first week of life × 1000 No. of live births
  • 14. Perinatal Mortality Rate (PMR) No. of still births/ late foetal deaths (after 28 weeks of gestation) plus deaths within first week of life in a year and geographical region for 1000 births (live and still) in a year and region. Foetal deaths after 28weeks of gestation + deaths of newborns within 7days PMR= × 1000 No. of live births during the same year
  • 15. Post Neonatal Mortality Rate (PNMR) Number of infants deaths after 28 days to less than 1yr (between 4 weeks to 52 weeks) of age per 1000 live births in a given year. No. of deaths of newborns between 4weeks or less than 1yr old in a year PNMR= × 1000 No. of live births during the same yr
  • 16. Maternal Mortality Ratio (MMR) No. of deaths of women while pregnant or within 42 days of termination of pregnancy from any cause related to pregnancy/ childbearing and child birth per 100,000 live births in a given year. Deaths of pregnant women and women after termination of pregnancy within 6 weeks from any cause related to pregnancy MMR= × 100000 No. of live births during the same year
  • 17. Maternal Mortality Rate (MMRT) Number of maternal deaths while pregnant or within 42 days of termination of pregnancy from any cause related to pregnancy/ childbearing and childbirth per 100,000 women in reproductive ages 15-49. No. of maternal deaths of women in age 15-49 MMRT = × 1000 No. of women in age 15-49 in a given yr
  • 18. Foetal Death: Deaths prior to the complete expulsion or extraction from its mother of a product of conception at any time of pregnancy.  Still Birth Death of foetus after completing 28 weeks and till the time of birth.  Incidence Rate Number of NEW cases of specified diseases occurring in a defined population during a specified period of time.
  • 19. (Continued…………) No. of new cases of specified disease during a given period Incidence rate = × 1000 Population at risk Prevalence Rate Number of all current cases (old and new) of a disease at one point in time in relation to defined population. No. of new and old cases of specified disease existing at a given point in time Prevalence rate = × 1000 Estimated population at the same point in time
  • 20. s th ks of gestation completed Toddler Post Late Early Still Birth Death Neonatal Neonatal Neonatal Death Death Death Neonatal Death Perinatal Death Infant Death Time Reference for Mortality in Childhood and Infancy
  • 21. Limitations of Measures of Mortality  The risk in a population may vary largely with various socio-economic and biological traits.  The lack of reliable and requisite data presents serious problem sometimes of considerable magnitude.
  • 22. Exercise: Calculate the crude and Age specific death rates of the population from the following data Age-group Population Deaths (Years) Under 10 20,000 600 10-20 12,000 240 20-40 50,000 1,250 40-60 30,000 1,050 Above 60 10,000 500
  • 23. Expectation of Life  The curate Expectation of life, (ex) gives the average number of completed years of life lived by the cohort l0 after age x by each of lx persons attaining that age. The complete expectation of life, denoted as exo, measures the average number of years a person of given age can be expected to live under the prevailing mortality conditions. It gives the number of years of life entirely completed and includes the fraction of the year survived in the year in which death occur, which on the average can be taken to be ½ years. exo = ex +1/2
  • 24. REFERENCE  An Introduction to the Study of Population, Bhaskar D. Mishra  Techniques of demographic Analysis, K. B Pathak, F. Ram  Fundamentals of Applied Statistics, S.C Gupta and V. K Kapoor.