Python Notes for mca i year students osmania university.docx
Acid base balance
1.
2. • Definition & types of acid and base
• Sources of acid
• Why regulation is important?
• Defences against change in {H+}
• Acid base disorders
• Compensation
• Diagnosis
• Treatment
3. • Definition of an acid and a base
• Types of acids and bases
based on different criteria
• Is the precise regulation of free(unbound) hydrogen
ion concentration in the body fluids
4. • Carbonic acid formation
• Inorganic acids produced during breakdown of nutrients
sulfuric acid and phosphoric acid…
• Organic acids resulting from intermediary
metabolism
lactic acid,fatty acids…
5. • Changes in excitability of nerve and muscle cells
acidosis - depression of the central nervous system
(CNS)
alkalosis- overexcitability of the nervous system
• Exerts a marked influence on enzyme activity
• Influence K+ levels in the body
• Even to death
6. (1) chemical buffer systems,
(2) respiratory mechanism of pH control,and
(3) renal mechanism of pH control
7. • Is a mixture in a solution of two chemical
compounds that minimize pH changes when either
an acid or a base is added to or removed from the
solution
• by converting strong acids and bases into weak
acids and weak bases with in fractions of a second
• It is the first line of defense
8.
9. Types of buffer
• Protein buffer system
is the most abundant buffer in intracellular fluid(Hb)
and blood plasma(albumin)
Approximately 60 to 70 percent of the total chemical
buffering of the body fluids is inside the cells, and most
of this results from the intracellular proteins
COOH as an acid and NH2 as a base
11. • Phosphate buffer system
Uses dihydrogen phosphate and monohydrogen
phosphate
It plays a major role in buffering renal tubular fluid
and intracellular fluids
13. • Carbonic Acid–Bicarbonate Buffer System
is based on the bicarbonate ion(HCO3) and carbonic
acid(H2CO3)
Can not protect against pH changes due to respiratory
problems in which there is an excess or shortage of CO2
15. • As a second line of defense
• Through its ability to alter pulmonary ventilation and
consequently to alter excretion of H+-generating CO2
• Doubling the ventilation increases pH by about 0.23 units,
from 7.4 to 7.63
• Reducing ventilation to one-quarter of normal lowers the
pH by 0.4 units, from 7.4 to 7.0.
• one to two times as much acid or base can normally be
buffered by this mechanism as by the chemical buffers
16. Changes in either pulmonary ventilation or the rate of CO2
formation by the tissues can change the extracellular fluid
Pco2
17. Not only does the alveolar ventilation rate influence H+
concentration by changing the Pco2 of the body fluids, but
the H+ concentration affects the rate of alveolar ventilation
18.
19. is third line of defense
Uses
(1) H+ excretion,
(2) Reabsorption of filtered HCO3–
(3) ammonia (NH3) secretion
(4) filtered phosphate
Ammonia and phosphate mechanism produce new
bicarbonate
27. • Respiratory compensation
Is only for metabolic acidosis and alkalosis
For metabolic acidosis - hyperventilation
For metabolic alkalosis – hypoventilation
• Renal compensation
For both metabolic and respiratory
For acidosis – absorb bicarbonate
For alkalosis - excrete bicarbonate
28. • For acidosis
sodium bicarbonate
sodium lactate
sodium gluconate
• For alkalosis
ammonium chloride
lysine monohydrochloride
29. • Guyton,12e
• Principles of ANATOMY &PHYSIOLOGY,13e
• Ganong’s Review of Medical Physiology,23e
• Fundamentals of Human Physiology,4e
• Kaplan