Beta Blockers

1. NON SELECTIVE BETA-BLOCKERS
BY
SHIVA HOSUR

2. WHAT ARE BETA BLOCKERS ??
 BETA BLOCKERS ARE THE DRUGS THAT BLOCK
THE ACTION OF CATECHOLAMINES MEDIATED
THROUGH β RECEPTORS
 ALL β BLOCKERS ARE COMPETATIVE
ANTAGONISTS

3. CLASSIFICATION

4. PHARMACOLOGICAL ACTIONS
 HEART – beta blockers decreases HR, FORCE OF
CONTRACTION, CARDIAC OUTPUT BP FALLS
 AV CONDUCTION IS DELAYED DUE TO BLOCKADE OF
BETA RECEPORS IN AV NODE ,THUS MYOCARDIAL
OXYGEN REQUIREMENT IS REDUCED DUE TO REDUCED
CARDIAC WORK.
 BETA-BLOCKERS PREVENTS EXERCISE –INDUCED IN HR
& FORCE OF CONTRACTION

5. PHARMACOLOGICAL ACTION
 RESPIRATORY TRACT- BLOCKADE OF β2 RECEPTORS IN
BRONCHIAL SMOOTH MUSCLE CAUSES AN INCREASES IN
AIRWAY RESISTANCE MAY PRECIPITATE ACCUTE ATTACK IN
ASTHMATICS.
 EYE- MANY BETA BLOCKERS REDUCES IOP BY DECREASED
SECRETION OF AQUEOUS HUMOUR
 OTHER EFFECTS- MANY BETA BLOCKERS IN HIGHER DOSES
SODIUM CHANNELS AND HAVE A LOCAL ANAESTHETIC
EFFECT- MEMBRANE STABLISING EFFECT

6. NON SELECIVE BETA BLOCKERS
 SOTALOL-NON SELECTIVE ,HAS ADDITIONAL POTASSIUM
CHANNEL BLOCKING PROPERTY.
 NADOLOL- LONG ACTING BETA BLOCKER ,USED IN
HYPERTENSION,ANGINA ,OESOPHAGEAL VARICES,MIGRANE
PROPHYLAXIS AND IN TREMORS.

7. BETA BLOCKER IN EYE

11. PINDOLOL OXPRENOLOL & PENBUTALOL
 NON SELECTIVE, PARTIAL AGONISTS ACT BETA 1 & BETA 2
RECEPTORS .
 PENBUTOLOL IN ADDITION HAS WEAK INTRINSIC SYMPATHOMIMETIC
ACTIVITY.
ADVANTAGES
 MILDER BRADYCARDIA
 MILDER MYOCARDIAL DEPRESSION
 BETTER TOLERATED IN ASTHMATICS
 MILDER EFFECT ON LIPID PROFILE
 LESS CHANCES OF REBOUND HYPERTENSION ON WITHDRAWAL.

12. DIS ADVANTAGE
 NOT SUITABLE FOR PROPHYLAXIS OF MIGRANE AND
MYOCARDIAL INFARCTION
DOSES
 PINDOLOL-10-30 mg
 OXPRENOLOL -40-80mg
 PENBUTALOL-20-80mg
 LEVATOL 20,40mg

13. ADVANTAGES OF CARDIO SELECTIVEβ BLOCKERS
OVER NON SELECTIVE β BLOCKERS
I. SAFER IN ASTHMATICS
II. SAFER IN DIABETES
III. PERIPHERAL VASCULAR DISEASES
IV. LESS DELETERIOUS EFFECTS ON LIPID PROFILE
V. LESS LIABLE TO IMPAIR EXERCISE CAPACITY

14. Third generation beta blockers
 THESE INCLUDES ,CARVEDILOL,CARTELOL,LAVETALOL,BUCINDALOL
 THESE ARE BETA BLOCKERS WITH ADDITIONAL VASODIALATORY
PROPERTIES
 CARTELOL- NON SELECTIVE BETA BLOCKER WITH PARTIAL
AGONISTIC ACTIVITY AT β1 RECEPTORS AND THUS CAUSES
BRADYCARDIA
 CARVEDILOL- BLOCKS β1,β2 & α1 RECEPTORS IT ALSO HAS
MEMBRANE STABILIZING AND ANTI INFLAMMATORY PROPERTIES.