Download to read offline
Vascular interventions atalar- johns hopkins
This document discusses vascular interventions guided by MRI, including: 1) Early experiments with intravascular MRI to image arteries and plaques. 2) The technical challenges of MRI-guided balloon angioplasty and stent placement, such as developing MRI-compatible devices and monitoring procedures. 3) Examples of MRI-guided balloon angioplasty, stent placement, and plaque imaging in human studies. 4) The potential for MRI to guide new treatments like gene therapy delivery to diseased arteries.
More Related Content
Similar to Vascular interventions atalar- johns hopkins
More from Society for Heart Attack Prevention and Eradication
![PERI-PROSTHETIC FRACTURE NAIL-PLATE CONSTRUCT [NPC].pptx](https://cdn.slidesharecdn.com/ss_thumbnails/drarunkumardrmohamedashrafperiprostheticfrasturenail-plateconstructnpc-260209164459-7e9d15a1-thumbnail.jpg?width=640&height=640&fit=bounds)
Vascular interventions atalar- johns hopkins
- 1. Vascular InterventionsVascular Interventions ErginAtalar, Ph.D.Ergin Atalar, Ph.D. Johns Hopkins UniversityJohns Hopkins University Departments of Radiology and Biomedical EngineeringDepartments of Radiology and Biomedical Engineering DISCLOSURE:DISCLOSURE: E. Atalar is a founder and stock holder of Surgi-Vision, Inc.E. Atalar is a founder and stock holder of Surgi-Vision, Inc.
- 2. Johns Hopkins University OverviewOverview –Intravascular MRI (first human experiments)Intravascular MRI (first human experiments) – Balloon AngioplastyBalloon Angioplasty – Stent PlacementStent Placement – MR-guided Gene TherapyMR-guided Gene Therapy
- 3. Johns Hopkins University IntravascularMRIIntravascular MRI
- 4.
- 5. Johns Hopkins University mm B FSE,1200/13-msec TR/TE, Double IR blood suppression, 16 ETL, 4-cm FOV, 32 NEX, 256x256 matrix, 10 min 14 sec acquisition time ACM • Resolution: 150 µm J. M. Serfaty et al. Watanabe rabbit with a 0.032” MRI-Guidewire Aortic wall imaging
- 6. Johns Hopkins University Poststent: human iliac IVMRIPost stent: human iliac IVMRI L. Hofmann, D. Bluemke Rt common iliac art. Guidewire (venous) Fibrous cap Lipid core T1 - pre gad T1 - post gad
- 7. Johns Hopkins University L.Hofmann, D. Bluemke Fibrous cap Lipid core Plaque CharacterizationPlaque Characterization
- 8. Johns Hopkins University Restenosis- s/p renal stentRestenosis - s/p renal stent 5 mm L. Hofmann, D. Bluemke Rt renal artery Guidewire in IVC restenosis
- 9. In-Vivo Human IliacArtery:In-Vivo Human Iliac Artery: Concentric AtherosclerosisConcentric Atherosclerosis Angiography 20 MHz IVUS IVMRI No Abnormality Concentric Atherosclerosis 5 mm 5 mm Vein K. Yucel, et. al. Brigham and Women’s Hospital
- 10. Johns Hopkins University MR-guidedBalloon AngioplastyMR-guided Balloon Angioplasty Technical Challenges:Technical Challenges: – MR compatible/visible Balloon AngioplastyMR compatible/visible Balloon Angioplasty CatheterCatheter – Methods for Monitoring Balloon AngioplastyMethods for Monitoring Balloon Angioplasty ProcedureProcedure
- 11.
- 12.
- 13. Johns Hopkins University ScanRoomScan Room J. Serfaty et. al.
- 14. Johns Hopkins University MRI-guidedPTCAMRI-guided PTCA 90° 10° 90°10° slice selection projection J. Serfaty et. al.
- 15. DilatationDilatation of thePulmonary Arteryof the Pulmonary Artery C. Rickers, 2001
- 16. Dilatation with Gdfilled balloonDilatation with Gd filled balloon C. Rickers, 2001
- 17. Dilatation with airfilled balloonDilatation with air filled balloon C. Rickers, 2001
- 18. Johns Hopkins University MR-guidedStent PlacementMR-guided Stent Placement Technical ChallengesTechnical Challenges – MR compatible and visible stent deploymentMR compatible and visible stent deployment devicedevice – MR compatible stentMR compatible stent – Methods of monitoring stent placementMethods of monitoring stent placement procedureprocedure
- 19. Johns Hopkins University MRGuidewire Tracking/PlacementMR Guidewire Tracking/Placement sheath FGREFGRE 256x162256x162 20 mm slice20 mm slice 4 element4 element cardiac coilcardiac coil A. Lardo et. al.
- 20. Johns Hopkins University MRIGuided Stent Positioning and DeploymentMRI Guided Stent Positioning and Deployment stent liver stomach Ao SPGRSPGR 256x162256x162 TR/TE=4.4/1.2TR/TE=4.4/1.2 20 mm slice20 mm slice 4 element cardiac4 element cardiac coilcoil A. Lardo et. al.
- 21. Johns Hopkins University IntravascularWire StentIntravascular Wire Stent CrossingCrossing SPGRSPGR 256x162256x162 TR/TETR/TE 20 mm slice20 mm slice 3 element3 element cardiac coilcardiac coil + 1 element+ 1 element internal coilinternal coil stent 1 stent 2 MRI guidewire A. Lardo et. al.
- 22. Johns Hopkins University HighResolution Aortic ImagingHigh Resolution Aortic Imaging stent MRIG (Imaging Guidewire) SPGR, 256x256, FOV=4 cm Guidewire element only stented wall 156µm A. Lardo et. al.
- 23. Johns Hopkins University MR-guidedGene Therapy
- 24. A Remedy genedelivery balloon catheter Gene delivery channel Angioplasty balloon channel Guidewire channel 0.014” MRIG Tuning box X. Yang, et al. Circulation 2001
- 25. Johns Hopkins University Design Plaque Plaque Vessel 0.014”MRIG Balloon inflation with 3% Gd Gd/blue-dye medium or Gd/GFP-lentivirus medium X. Yang, et al. Circulation 2001
- 26. Johns Hopkins University BA X Clinicalsignificance? X. Yang, et al. Circulation 2001
- 27. Johns Hopkins University ConclusionConclusion MRI has potential to guide new and conventional vascular interventions