Plegable biología molecular. Universidad Pontificia Bolivariana.

1. DNA REPAIR MECHANISMS
Luisa María Mesa
Medicine Student
III semester

4. INTRODUCTION
As the cell develops lots of mutations:
Induced by:
Chemicals
Radiation
It also develops DNA repair mechanisms:
Substitution, insertion or deletion
of bases or nucleotides,
mismatches, strand’s breaks, and
crosslinks.
Base excision repair,
nucleotides excision repair,
strand breaks repair and
mismatch repair.

5. GENE SWITCH MAY REPAIR
DNA, PREVENT CANCER
(2016, FEBRUARY 13TH
)
JOURNAL CELL REPORTS

6. GENE SWITCH MAY REPAIR DNA,
PREVENT CANCER

7. GENE SWITCH MAY REPAIR DNA,
PREVENT CANCER
BOTH MOLECULES PLAY AN
IMPORTANT ROLE IN DNA
REPAIR

8. GENE SWITCH MAY REPAIR DNA,
PREVENT CANCER
"Our results imply that loss of TET enzymes
and 5hmC depletion could contribute
significantly to genome instability and
inaccurate chromosome segregation,
perhaps explaining the correlation of low
5hmC levels with cancer.”

9. GENE SWITCH MAY REPAIR DNA,
PREVENT CANCER
I think this new finding is important because
everyday we discover new paths that cells take to
protect themselves, that give us new ways of
treatment specially in cancer. Now as we know,
scientists and doctors have a new enzyme that
could help to cure a defeating illness as cancer.

10. STUDY PROVIDES VITAL
INFORMATION ABOUT
MECHANISM GOVERNING
DNA REPAIR.
(2016, JANUARY 31)
NUCLEIC ACIDS RESEARCH
JOURNAL

11. STUDY PROVIDES VITAL INFORMATION ABOUT
MECHANISM GOVERNING DNA REPAIR
DNA wraps around proteins
called histones to form
chromatin. Cells can
chemically modify histones
so they can control the
various functions of DNA.

12. STUDY PROVIDES VITAL INFORMATION
ABOUT MECHANISM GOVERNING DNA
REPAIR

13. STUDY PROVIDES VITAL
INFORMATION ABOUT
MECHANISM GOVERNING DNA
REPAIR
THE FDA APPROVE A HDAC INHIBITOR IN 2006:
VORINOSTAT (ZOLINZA®)

14. STUDY PROVIDES VITAL INFORMATION ABOUT
MECHANISM GOVERNING DNA REPAIR
This similar study is also important, because it let us
understand another way to develop cancer, and could
guide future researchers to find new targeted antidotes.
This demonstrate how cancer “develops” new
mechanism, and so are we, developing new ways to beat
it.

15. MEDICAL UTILITY

16. MEDICAL UTILITY
It’s important to identify the mechanisms that can cause
damages to the DNA, such as exogenous factors as
chemotherapy, UV light, radiation; and endogenous factors
as free radicals; so we can act first, by preventing or
modifying the exposure to these damaging factors.

17. MEDICAL UTILITY
DNA repair is the first pathway we can use to
develop cancer therapies; because DNA damage is
a fundamental problem in life and it’s the main
cause of this illness. When we achieve to fully
understand the DNA repair mechanisms, we
would be one step ahead of this disease and it
would give multiple opportunities to people with
cancer or another diseases tan involve DNA
damage or damage in the DNA repair mechanism.
Fortunately now, we are
improving, and this is seen at the
HDAC inhibitor.

18. It is also important because
it does not only help with
cancer itself, but it helps to
repair the cell after the
exposure to the
chemotherapy that the
cancer’s patients
experiment.

19. BIBLIOGRAPHY
• · Study provides vital information about mechanisms governing DNA repair.
(2016, January 31). Retrieved February 14, 2016, from http://www.news-
medical.net/news/20160131/Study-provides-vital-information-about-
mechanisms-governing-DNA-repair.aspx
• · Gene Switch May Repair DNA, Prevent Cancer. (2016, February 13).
Retrieved February 14, 2016, from
http://www.tasnimnews.com/en/news/2016/02/13/999294/gene-switch-may-
repair-dna-prevent-cancer