This study examined differences in physical activity levels between adolescent males and females with and without disabilities using data from the 2017 Finnish School Health Promotion Study. The study found that males were more likely to meet physical activity recommendations compared to females. Among inactive youth, females reported participating in more physical activity than males. Additionally, adolescents with certain disabilities like seeing or hearing difficulties did not necessarily have lower physical activity levels than peers without disabilities. The study provides insight into targeting physical activity interventions for specific subgroups.