Regression is a statistical tool used to predict unknown values of a dependent variable from known values of one or more independent variables. It estimates the average change in the dependent variable given a change in the independent variable(s). There are two regression lines - one with Y as the dependent variable (Y on X) and one with X as the dependent variable (X on Y). The regression equation expresses these lines algebraically. The constants a and b are estimated using the method of least squares, which finds the line that minimizes the vertical differences between actual and estimated Y values. Multiple regression uses more than one independent variable to increase prediction accuracy.