2. • from the Latin calyx “chalice”
or Cup
• Often referred as “Small round structured
viruses”

3. •
•
•
•
non-enveloped
27-40 nm in diameter
Icosahedral symmerty
Some have characteristic appearance with 32
cup shaped depressions on their surface
• Linear
• Positive sense single-stranded RNA viruses

5. Encompasses 4 clinical syndromes:
• Swine Vesicular Exanthema
• San Miguel Sea Lion Virus
• Feline Calicivirus
• Rabbit Hemorrhagic Disease

6. Group IV; single stranded RNA positive-strand
viruses
Family: Caliciviridae
Genus:
Lagovirus
Nebovirus
Norovirus
Sapovirus
Vesivirus

7. 1.Attachement to host
receptors mediates e
ndocytosis of the
virus into the host
cell.
2.Uncoating,
and
release of the viral
genomic RNA into
the cytoplasm.

8. 3.VPg is removed from
the viral RNA, which is
then translated into a
processed ORF1polypr
otein to yield the
replication proteins.
4.Replication
occurs
in viral factories. A
dsRNA genome
is
synthesized from the
genomic ssRNA(+).

9. 5. The dsRNA genome
is transcribed/replicate
d thereby providing
viral
mRNAs/new
ssRNA(+) genomes.
6.
Subgenomic RNA tran
slation gives rise to the
capsid
protein
and VP2.

10. 7. Assembly of new virus
particles and release
by cell lysis.

12. • Swine Vesicular Exanthema
• San Miguel Sea Lion Virus
• Feline Calicivirus
• Rabbit Hemorrhagic Disease

13. Vesicular Exanthema infection of Porcine

14. Rabbit Hemorrhagic Disease

16.  a common respiratory disease in cats
 virus attacks the respiratory tract -- lungs and nasal
passages -- the mouth, with ulceration of the tongue, the
intestines, and the musculoskeletal system

17. Causative agent:
Clinical Signs:
conjunctivitis
rhinitis
tracheatis
pneumona and vesiculation,
ulceration of the oral epithelium
fever
anorexia
lethargy
stiff gait

18. Nasal discharge and vesicles & ulcers on the tongue of a cat infected with FCV.

19. Tongue ulcerative glossitis from a FCV case.

20. Lesions: on muzzle and tongue, respiratory tract, oral cavity
and eyes.
Pathogenesis:
natural transmission occurs via
aerosol and fomites; the virus is often carried to susceptible cats by
human handlers.

21. Radiographs of interstitial pneumonia.

22. Histopathology & gross pathology of interstitial pneumonia from a FCV case.

23. Lymphocytic-plasmacytic stomatitis in a cat.

24. Lesions in the eyes

25. DISEAS CAUSATI
ES
VE
AGENT
SAMPLE/s
DIAGNOSTIC
TEST
SWINE
VESICULAR
EXANTHEMA
VESIVIRUS
Vesicular fluid, mucous
membranes
SEROLOGIC TEST
ELECTRON MICROSCOPY
FELINE
CALICIVIRUS
VESIVIRUS
oral swabs, blood, skin
scrapings or lung tissue
PCR,
IMMUNOFLOURESCENCE
ENZYME IMMUNOASSAY
RABBIT
HEMORRHA
GIC DISEASE
LAGOVIRUS
Spleen, liver , blood
IMMUNOFLOURESCENCE
ENZYME IMMUNOASSAY
SAN MIGUEL
SEA LION
VIRUS
VESIVIRUS
Tissue samples, fecal
samples
ELISA
Immunoflourescence
PCR

26.  There is no specific treatment for FCV
 Antibiotics are used for secondary bacterial
infections, and immune modulators, such as
lymphocyte T-cell immune modulator, have been used
for immune support.

27.  Nursing care and rehydration are used for
dehydrated and anorexic cats
 Routine vaccination.
Avoiding overcrowding of feline
populations, reducing stress.