Lymphogranuloma Venereum Dr. Yashika Causative agent : Chlamydia trachomatis Incubation period: 3-30 days Clinical features : Initial phase: Painless papule, pustule or ulcer in vulva, urethra, rectum or cervix. Involved inguinal nodes feels rubbery. Acute lumphangitis and lymphadenitis. Necrosed glands and abscess formation. Rupture of abscess occurs within 7-15 days. Sinus and fistula formation. Intense fibrosis with lymphatic drainage. Secondary phase : Painful adenopathy. Classical clinical sign: Groove sign A depression between the groups of inflammed nodes. Complication: Vulval elephantiasis Perineal scarring Rectal stricture Sinus and fistula formation. Diagnosis Culture and isolation Detection of LGV Treatment: Doxycycline 100 mg BID x 21days. Azithromycin 1 gm PO weekly x 3 weeks Abscess aspiration

1. Lymphogranuloma Venereum
Dr. Yashika

2. • Causative agent : Chlamydia trachomatis
• Incubation period: 3-30 days

3. Clinical features :
Initial phase:
• Painless papule, pustule or ulcer in vulva, urethra,
rectum or cervix.
• Involved inguinal nodes feels rubbery.
• Acute lumphangitis and lymphadenitis.
• Necrosed glands and abscess formation.
• Rupture of abscess occurs within 7-15 days.
• Sinus and fistula formation.
• Intense fibrosis with lymphatic drainage.

4. Secondary phase : Painful adenopathy.
Classical clinical sign:
• Groove sign
A depression between the groups of inflammed nodes.

5. Complication:
• Vulval elephantiasis
• Perineal scarring
• Rectal stricture
• Sinus and fistula formation.

6. Diagnosis
• Culture and isolation
• Detection of LGV

7. Treatment:
Doxycycline 100 mg BID x 21days.
Azithromycin 1 gm PO weekly x 3 weeks
Abscess aspiration