30. cont. functions of PKS
• PKC isozymes phosphorylate an abundance of substrates, leading to
both short-term cellular responses such as regulation of membrane
transport and long-term responses such as memory and learning.
33. Calmodulin..
• This is the protein mediator of many Ca2-stimulated
enzymatic reactions
• Each of the four Ca2-binding
sites occurs in a helix-loop-helix motif called the EF hand, also found in
many
other Ca2-binding proteins.
• Calmodulin associated with a helical domain (red) of one of the many
enzymes it regulates
34. • Calmodulin can be one of numerous subunits of complex proteins and
is particularly involved in regulating various kinases and
enzymes of cyclic nucleotide generation and degradation
35.
36.
37.
38. Structure of Ca2+/calmodulin complex based on
X-ray diffraction and NMR spectroscopy studies
Molecular Biology of the Cell, 2002
