Young-Onset Parkinson Disease
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Young-onset Parkinson's disease (YOPD) is defined as Parkinson's disease (PD) with an onset before age 40. It features a focal dystonia as a common early symptom and slower disease progression than older-onset PD. YOPD also sees hyperkinetic dyskinesia and dose-related motor fluctuations relatively early in treatment. Genetics play a stronger role in YOPD than older-onset PD, but the underlying Lewy body pathology is the same.
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Illness Management.
1
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Patient information
Name: Luis Morel
Age: 62 years
Gender: Male
RACE: HISPANIC
MARITAL Status: Married
Medication Intolerance: Denied
Allergies: Seafood.
Chronic Illnesses/Major traumas: Controlled Hypertension
Hospitalizations/Surgeries: Inguinal Hernia (2 years ago).
Immunization: Updated (PCV13, Influenza, RZV,).
Hospitalizations/Surgeries: Denied
2
Epidemiology of Parkinson Disease
First symptoms appear usually after age of 40 years but have been reported cases in children’s and is called Juvenile Parkinsonism.
Aged 50 years and over are affected in 1 %, this number increased in 10 % in person 60 years and over about 1½ times more common in men than in women.
The causes of Parkinson's disease (PD), the second most common neurodegenerative disorder, are still largely unknown. Current thinking is that major gene mutations cause only a small proportion of all cases and that in most cases, non-genetic factors play a part, probably in interaction with susceptibility genes. Numerous epidemiological studies have been done to identify such non-genetic risk factors, but most were small and methodologically limited. Larger, well-designed prospective cohort studies have only recently reached a stage at which they have enough incident patients and person-years of follow-up to investigate possible risk factors and their interactions.
3
Etiology
Primary (idiopathic- most common):
unknown origin but not induced by obvious stimulus.
Secondary (parkinsonism): related to drugs, stroke, or trauma, other stimuli
Familial: Genetics related, are included 20 % of the existing cases diagnosed
4
Risk Factors
Heredity.
Age. (60 or older)
Sex.
Autoimmune factors
Exposure to toxins
5
Thinking difficulties
Depression and emotional changes
Swallowing problems
Chewing and eating problems
Sleep problems and sleep disorders
Bladder problems
Constipation
Blood pressure changes
Smell dysfunction
Sexual dysfunction
fatigue
Associated conditions
6
PATIENT history
Patient is 62 years old, male, Hispanic descendent, recently discharged from US Army after 25 years of service. He is today looking for medical advice after has been notice a little resting tremor in both hands more marked in right hand, also noted slow motion in some movement mainly with changes of position and some incoordination when he walks. He is concerned because his paternal Grandfather died after suffering for many years with Parkinson’ s disease related disabilities, his father died at 43 years old in a motor vehicle accident and no time to development the disease and he hears that Parkinson’s Disease has some genetics implication. His medical history is only remarkable for a 10 years history of well cont.
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Ped lupused
this i take from i cant remember the website. i find it interesting and easy to understand and i upload it, so that i can read it anytime i want without losing it..... lets us together read.
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- 1. Young-Onset Parkinson Disease Ade Wijaya, MD – January 2019
- 2. Introduction • PD onset < 40 ; rare • 21-40 young onset PD • < 20 juvenile PD • Lewy Body pathology
- 5. Clinical Features • A frequent early feature: focal dystonia • Slower disease progression • YOPD encounter hyperkinetic dyskinesia and dose-related motor fluctuations relatively early in the treatment course.
- 6. Pathology and Genetics • Lewy Body • Stronger genetics than old-onset PD
- 8. Differential Diagnosis • Wilson disease • Drug-induced parkinsonism • Olivopontocerebellar atrophy • Rigid-onset Huntington’s disease • Hallervorden-Spatz disease • Dopa-responsive dystonia • Multiple-system atrophy • Tumors of the basal ganglia • Intoxication by carbon monoxide, carbon disulfide, MPTP, or manganese
- 10. Summary • YOPD appears to be the same pathologic entity as older-onset PD • Genetics • Slower progression • Dystonic onset • More dyskinesia