Spontaneous intracranial hypotension is a medical condition caused by loss of cerebrospinal fluid from the spinal canal, resulting in headaches and neurological symptoms. It most commonly presents with orthostatic headaches that are less apparent over time. Brain MRI and spine MRI are used to diagnose and locate CSF leaks. Treatment involves conservative measures, percutaneous patching of leaks, or surgical closure. Spontaneous intracranial hypotension can lead to complications like subdural hematomas if not properly diagnosed and treated.
Definitions, etiologies and symptoms of intracranial hypertension included. Relevance of intracranial hypertension to ophthalmologist and grading of papilledema discussed. Detailed discussion of Idiopathic Intracranial Hypertension (IIH), including the diagnostic criteria, clinical and radiological diagnosis, management and monitoring of IIH discussed.
Definitions, etiologies and symptoms of intracranial hypertension included. Relevance of intracranial hypertension to ophthalmologist and grading of papilledema discussed. Detailed discussion of Idiopathic Intracranial Hypertension (IIH), including the diagnostic criteria, clinical and radiological diagnosis, management and monitoring of IIH discussed.
A case report of posterior reversible encephalopathy syndrome in a patient di...bijnnjournal
Posterior reversible encephalopathy syndrome (PRES), a clinical radiological syndrome, is characterized by the
abrupt development of neurological symptoms such as headaches, convulsions, altered sensorium, and visual
problems. PRES has been linked to a number of risk factors or etiologies, including the use of immunosuppressants
or cytotoxins, hypertensive encephalopathy, eclampsia, preeclampsia, and underlying autoimmune diseases.
A 41-year-old female was admitted with acute necrotizing emphysematous pancreatitis complicated by posterior
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
1. A D E W I J A Y A , M D – M A Y 2 0 2 3
Spontaneous Intracranial Hypotension
2. Introduction
A debilitating medical condition caused by loss of
CSF from the spinal canal
Not life threatening but cause considerable
morbidity, result in significant long-term disability,
and in rare cases leads to decreased level of
consciousness and coma
Takai K, Niimura M, Hongo H, et al. Disturbed Consciousness and Coma: Diagnosis and Management of Intracranial Hypotension Caused by a Spinal Cerebrospinal Fluid Leak. World
Neurosurg 2019; 121: e700–11.
Kranz PG, Gray L, Malinzak MD, Amrhein TJ. Spontaneous Intracranial Hypotension: Pathogenesis, Diagnosis, and Treatment. Neuroimaging Clin N Am 2019; 29: 581–94.
Paris D, Rousset D, Bonneville F, et al. Cerebral Venous Thrombosis and Subdural Collection in a Comatose Patient: Do Not Forget Intracranial Hypotension. A Case Report. Headache 2020;
60: 2583–8.
3. Epidemiology
Incidence: 5 cases per 100 000 person-years
Female : Male = 2 : 1
The peak incidence is around 40 years of age, and
SIH is rare but not absent in children
Risk factors: connective tissue disorder such as
Marfan syndrome and Ehlers-Danlos syndromes
Luetzen N, Dovi-Akue P, Fung C, Beck J, Urbach H. Spontaneous intracranial hypotension: diagnostic and therapeutic workup. Neuroradiology. 2021 Nov;63(11):1765-72.
Dobrocky T, Nicholson P, Häni L, Mordasini P, Krings T, Brinjikji W, Cutsforth-Gregory JK, Schär R, Schankin C, Gralla J, Pereira VM. Spontaneous intracranial hypotension: searching for the
CSF leak. The Lancet Neurology. 2022 Feb 25.
Samanta D. Headaches in Loyes-Dietz Syndrome. J Child Neurol 2019; 34: 144–7.
Pichott A, Bernstein T, Guzmán G, Fariña G, Aguirre D, Espinoza A. Dural ectasia and intracranial hypotension in marfan syndrome. Rev Chil Pediatr 2020; 91: 591–6.
4. Clinical Presentation
Orthostatic headache; less apparent over time,
making correct diagnosis more challenging
Non-orthostatic forms of headache include
thunderclap, non-positional, exertional, cough-
related, and “second-half-of-the-day
Any patient with unexplained chronic headache
should be evaluated for potential SIH
Häni L, Fung C, Jesse CM, et al. Insights into the natural history of spontaneous intracranial hypotension from infusion testing. Neurology 2020; 95: e247–55.
Mokri B, Aksamit A, Atkinson J. Paradoxical Postural Headaches in Cerebrospinal Fluid Leaks. Cephalalgia 2004; 24: 883–7.
5. Pathophysiology
Increased efflux of CSF in the upright position,
leading to traction on pain-sensitive fibers within the
dura mater
Vestibulo-cochlear disturbances may result from
negative intracranial pressure transmitted through
the patent cochlear aqueduct and perilymph leading
to endolymphatic hydrops and Meniere’s disease
6. Pathophysiology
Additional symptoms such as diplopia, dysgeusia,
and vestibulo-cochlear disturbances may also occur
and are related to brain sagging and traction on the
cranial nerves. This phenomenon is due to the
decrease in buoyant force normally provided by the
CSF, which under physiological conditions reduces
downforce of the brain and uplifts the structures
despite gravity
Idris Z, Reza F, Abdullah JM. Human Brain Anatomy: Prospective, Microgravity, Hemispheric Brain Specialisation and Death of a Person. In: Human Anatomy - Reviews and Medical
Advances. InTech, 2017: 62–87.
Yamamoto M, Suehiro T, Nakata H, et al. Primary low cerebrospinal fluid pressure syndrome associated with galactorrhea. Intern Med 1993; 32: 228–31.
9. Brain MRI (Bern Score)
Dobrocky T, Grunder L, Breiding PS, Branca M, Limacher A, Mosimann PJ, Mordasini P, Zibold F, Haeni L, Jesse CM, Fung C, Raabe A, Ulrich CT, Gralla J, Beck J, Piechowiak EI (2019)
Assessing spinal cerebrospinal fluid leaks in spontaneous intracranial hypotension with a scoring system based on brain magnetic resonance imaging findings. JAMA Neurol 76:580–587
10. Spine MRI
T2-weighted sequences show so-called spinal
longitudinal extradural fluid (contrast) (SLEC) in
60% of patients.
Luetzen N, Dovi-Akue P, Fung C, Beck J, Urbach H. Spontaneous intracranial hypotension: diagnostic and therapeutic workup. Neuroradiology. 2021 Nov;63(11):1765-72.
11. Diagnostic Algorhytm
Luetzen N, Dovi-Akue P, Fung C, Beck J, Urbach H. Spontaneous intracranial hypotension: diagnostic and therapeutic workup. Neuroradiology. 2021 Nov;63(11):1765-72.
12. Luetzen N, Dovi-Akue P, Fung C, Beck J, Urbach H. Spontaneous
intracranial hypotension: diagnostic and therapeutic workup.
Neuroradiology. 2021 Nov;63(11):1765-72.
13. Farb RI, Forghani R, Lee SK, Mikulis DJ, Agid R. The
venous distension sign: a diagnostic sign of intracranial
hypotension at MR imaging of the brain. American
Journal of Neuroradiology. 2007 Sep 1;28(8):1489-93.
14. Farb RI, Forghani R, Lee SK, Mikulis DJ, Agid R. The venous distension sign: a diagnostic sign of intracranial hypotension
at MR imaging of the brain. American Journal of Neuroradiology. 2007 Sep 1;28(8):1489-93.
15. Complications
Formation of subdural hematomas
Transtentorial herniation with compression of the
diencephalon and traction on cerebral sinuses
resulting in deep venous thrombosis decreased
level of consciousness and coma
Brain superficial siderosis
Nonconvulsive status epilepticus
Cognitive decline (frontotemporal brain sagging
syndrome)
Dobrocky T, Nicholson P, Häni L, Mordasini P, Krings T, Brinjikji W, Cutsforth-Gregory JK, Schär R, Schankin C, Gralla J, Pereira VM. Spontaneous intracranial hypotension: searching for the
CSF leak. The Lancet Neurology. 2022 Feb 25.
16. Differential Diagnosis
Dobrocky T, Nicholson P, Häni L, Mordasini P, Krings T, Brinjikji W, Cutsforth-Gregory JK, Schär R, Schankin C, Gralla J, Pereira VM. Spontaneous intracranial hypotension: searching for the
CSF leak. The Lancet Neurology. 2022 Feb 25.
17. Treatment
Multidisciplinary setting by neurologists,
neuroradiologists and neurosurgeons
Conservative: bed rest and caffeine
Percutaneous treatment with epidural patching
(targeted or non-targeted)
Surgical or endovascular closure of the CSF leak or
fistula
Dobrocky T, Nicholson P, Häni L, Mordasini P, Krings T, Brinjikji W, Cutsforth-Gregory JK, Schär R, Schankin C, Gralla J, Pereira VM. Spontaneous intracranial hypotension: searching for the
CSF leak. The Lancet Neurology. 2022 Feb 25.
18. Treatment
Epidural blood patching in patients with SIH often
fails to provide permanent relief
Surgical repair of spinal CSF leaks can be curative
but requires precise preoperative leak localization
Spinal CSF-venous fistulas typically do not resolve
with blood patching and instead require surgical
obliteration or endovascular embolization
Dobrocky T, Nicholson P, Häni L, Mordasini P, Krings T, Brinjikji W, Cutsforth-Gregory JK, Schär R, Schankin C, Gralla J, Pereira VM. Spontaneous intracranial hypotension: searching for the
CSF leak. The Lancet Neurology. 2022 Feb 25.
19. Summary
Orthostatic headache
Brain and spine MRI
Low lumbar puncture opening pressure is not a
reliable marker of SIH
Consider a spinal CSF-leak in non-geriatric patients
with non-traumatic (bilateral) subdural hematoma