Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy

1. Ade Wijaya, MD – June 2023

2.  Focal cortical dysplasia
 Malformations of cortical development
 MOGHE, a recently recognized, highly
epileptogenic, distinct histopathological
entity in drug-resistant epilepsy that
primarily involves the frontal lobes
Seetharam R, Nooraine J, Mhatre R, Ramachandran J, Iyer RB, Mahadevan A. Mild
malformation of cortical development with oligodendroglial hyperplasia and epilepsy
(MOGHE): a widespread disease with an apparently focal epilepsy. Epileptic Disorders.
2021 Apr;23(2):407-11.

3.  Blurred gray-white matter boundaries due to
heterotopic neurons in white matter and
increased numbers of subcortical
oligodendroglial cells
 Increase of Olig2-immunoreactive
oligodendroglia observed in white matter and
deep cortical layers as well as increased
proliferation
 No evidence of dysmorphic neurons nor balloon
cells. There are also no signs for vertical nor a
horizontal dyslamination
J. Schurr, R. Coras, K. Rössler et al., “Mild malformation of cortical development with
oligodendroglial hyperplasia in frontal lobe epilepsy: a new clinico-pathological
entity,” Brain Pathology, vol. 27, no. 1, pp. 26–35, 2017.
H. Stefanits, T. Czech, E. Pataraia et al., “Prominent oligodendroglial response in surgical
specimens of patients with temporal lobe epilepsy,” Clinical Neuropathology, vol. 31, no.
6, pp. 409–417, 2012.

4. J. Schurr, R. Coras, K. Rössler et al., “Mild malformation of cortical development with
oligodendroglial hyperplasia in frontal lobe epilepsy: a new clinico-pathological
entity,” Brain Pathology, vol. 27, no. 1, pp. 26–35, 2017.

5. H. Stefanits, T. Czech, E. Pataraia et al., “Prominent oligodendroglial response in surgical
specimens of patients with temporal lobe epilepsy,” Clinical Neuropathology, vol. 31, no.
6, pp. 409–417, 2012.

6. Verentzioti A, Blumcke I, Alexoudi A, Patrikelis P, Siatouni A, Korfias S, Sakas D,
Gatzonis S. Epileptic patient with mild malformation of cortical development with
Oligodendroglial hyperplasia and epilepsy (MOGHE): a case report and review of the
literature. Case Reports in Neurological Medicine. 2019 Jun 9;2019.

7.  Epileptic surgery
 MOGHE could be associated with
unfavourable outcome in surgery of frontal
lobe in drug resistant epilepsy patients
J. Schurr, R. Coras, K. Rössler et al., “Mild malformation of cortical development with
oligodendroglial hyperplasia in frontal lobe epilepsy: a new clinico-pathological
entity,” Brain Pathology, vol. 27, no. 1, pp. 26–35, 2017.

8.  Emerging histopathological entity of brain
lesions
 Highly epileptogenic
 Drug resistant epilepsy
 Frontal lobe
 Diagnosis: MRI, pathology
 Could be associated with unfavorable
outcome in surgery