This document discusses the metabolism of xenobiotics, or foreign chemicals, in the body. It notes that xenobiotics are mostly lipophilic and cannot be easily cleared from the body. Their metabolism involves two phases - in the first phase enzymes like cytochrome P450 modify xenobiotics through reactions like hydroxylation and oxidation, while the second phase involves conjugating the substances to make them more water soluble and able to be excreted, through processes like glucuronidation and sulfation. Factors like genetic variability and drug interactions can impact an individual's ability to metabolize different xenobiotics. The document provides many examples of common xenobiotics and discusses how their metabolism can sometimes produce toxic effects.