Biochemistry quiz for 1st year MBBS students

1. Abstract Slide 1 MetaboLogic
Biochemistry
Quiz 2025
22.07. 2025
Department of Biochemistry, KIMS
Warmly welcomes all

3. Abstract Slide 2
Prof. Dr
Viyatprajna
Acharya
Prof Dr Jyotirmayee
Bahinipati
The Quiz Masters

4. The Scorers
Dr Subhashree
Nath
Dr. Ananya
Samantaray

5. General Round-I

6. 1. N-acetylneuraminic acid
(NANA) is present in
a) Phospholipid
b) Cerebroside
c) Ganglioside
d) TG

7. 2. The main lipid present in plasma
membrane is
a. Cholesterol
b. Triglyceride
c. Phospholipid
d. Fatty acids

8. 3. The smallest monosaccharide having stable furanose
ring str is
a) Erythrose
b) Ribose
c) Glucose
d) Fructose

9. 4. DNA absorbs light at wavelength of
a) 260nm
b) 360nm
c) 460nm
d) 560nm

10. 5. Which of the following is the most electronegative constituent of
ETC?
a) O2
b) NADH dehydrogenase
c) CoQ
d) Cytochrome oxidase

11. 6. What is the ratio of ECF/ICF volume in humans?
a) 1:2
b) 2:1
c) 1:3
d) 3:1

12. General Round-II

13. 1. Identify the structure

14. 2. Identify the structure

15. 3. Identify the molecule represented by the following structure

16. 4. Identify the molecule shown in the diagram.

17. 5. Identify the structure and mention its use

18. 6. Identify the structure and mention its use

19. Abstract Slide 5
SCORE??

20. Clinical Case Scenario

21. 1. Baby R, a 7-day-old full-term female infant, presents with
vomiting, poor feeding, lethargy, jaundice, and hepatomegaly.
Urine is positive for reducing substances but negative for glucose.
Blood glucose is low. Blood glucose -50mg%, Uric acid- 10 mg%,
Lactic acid- 15mmol/L, Plasma cholesterol- 300mg% and .
What is the most likely diagnosis?
A. Neonatal jaundice
B. Classic galactosemia
C. Crigler–Najjar syndrome
D. Hereditary fructose intolerance

22. 2. A 3-day-old male infant is brought to the emergency with vomiting,
lethargy, and rapid breathing. Blood tests reveal:
Plasma ammonia: Very high, Blood pH: 7.48, Serum glucose: Normal
No ketone bodies in urine, No acidosis
There is no history of infection or birth trauma. Urine organic acid levels
are normal.
What is the most likely diagnosis?
A. Maple syrup urine disease
B. Diabetic ketoacidosis
C. Ornithine Transcarbamoylase deficiency
D. Galactosemia

23. 3. A 55-year-old vegetarian man presents with complaints of fatigue, tingling
sensation in his feet, and difficulty in walking. On examination, he has pallor, a
beefy red tongue, and diminished position sense in the lower limbs. Blood tests
show: Hemoglobin: 8.5 g/dL, MCV: 110 fL (macrocytic), Serum B12: 150pg/ml,
Peripheral smear: Hypersegmented neutrophils.
Which of the following metabolic reactions is most likely impaired in this
patient?
A. Conversion of methylmalonyl-CoA to succinyl-CoA
B. Conversion of pyruvate to acetyl-CoA
C. Transamination of alanine to pyruvate
D. Conversion of succinyl-CoA to heme

24. 4. A 3-year-old boy is brought to the pediatrician due to delayed milestones, aggressive
behavior, and self-mutilation (biting his lips and fingers). His parents report that he
also has orange sandy crystals in the diaper. Lab tests show:
Serum uric acid: 10mg/dl, Neurological signs: Spasticity and dystonia
Which of the following enzyme deficiencies is most likely responsible for his
condition?
A. Adenosine deaminase
B. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
C. Galactose-1-P uridyl transferase
D. Glucose-6-phosphatase

25. 5.A 16-year-old girl presents with hyperextensible skin,
hypermobile joints, and a history of frequent bruising. She also
reports delayed wound healing. Her maternal uncle had died suddenly
of a ruptured aortic aneurysm.
Which of the following biochemical defects is most likely involved
in her condition?
A. Defective hydroxylation of proline and lysine residues in
collagen
B. Deficient glycosylation of collagen
C. Defective cross-linking of collagen fibrils due to lysyl oxidase
deficiency
D. Mutations in collagen genes affecting triple helix structure

26. 6. A 32-year-old woman presents for a routine health check-up. She
has no specific symptoms. Her thyroid profile shows the following:
TSH: 7.2 mIU/L (Normal: 0.4–4.0)Free T4: NormalAnti-TPO antibodies:
Positive. Her FBS was found lower than PPBS.
What is the most appropriate interpretation of her thyroid function
tests?
A. Overt hypothyroidism
B. Subclinical hypothyroidism
C. Euthyroid sick syndrome
D. Central hypothyroidism

27. Abstract Slide 5
SCORE??

28. Pictorial Round

29. 1. What is the primary component of
the structure shown:
a) Proteins
b) Carbohydrates
c) Phospholipids
d) Nucleic acids

30. 2. Identify the condition.

31. 3. Identify the plot and mention its significance.

32. 4. Identify the crystals.

33. 5. Identify the ophthalmic condition.

34. 6. Identify the type of enzyme inhibition.

35. Abstract Slide 3
SCORE??

36. Instrumentation round

37. Q1. Identify the Instrument

38. Q2. Identify the Instrument
?

39. Q3. Identify the Instrument

40. Q 4. Mention the technique used

41. Q5. Identify the Tube and mention
its use

42. Q6. Sharps like needles and broken glass would go
to which Bin?

43. Abstract Slide 5
SCORE??

44. Step Ladder Round

45. I am an enzymatic cardiac marker raised after 24 hours of
heart attack and can be found in blood after 8-10 days
I am also found in RBC, brain, liver, skeletal muscle
I am a tetramer
I have 4 other siblings
1

46. I’m a water-soluble vitamin, in high sustained
release dose I can lead to hepatotoxicity
I am a bridge between carbohydrates and ATP, aiding
dehydrogenases in their harvest.
I’m synthesized from an aromatic amino acid.
My deficiency scars the skin and mind, especially
when sunlight strikes.
2

47. I’m an amino acid, with a net positive charge at
physiological pH and my presence boosts wound
healing and immune responses.
I become essential for infants and in trauma
and illness
I contribute to a cyclic process crucial for nitrogen
balance.
I contain a guanidine group
3

48. I’m a hidden flaw, an enzymopathy, often unnoticed until
challenged by nature or medicine.
Infection, beans, or a bitter pill for malaria may expose
me.
My victims suffer oxidative stress but can’t regenerate a
reducing agent.
I leave behind Heinz bodies and bite cells on a smear.
4

49. I’m an organelle known as microbody
My marker enzyme is catalase
I’m involved in very long chain fatty
acid metabolism
I remove unwanted peroxides and free
radicals from the cell
5

50. I’m a reducing equivalent helping
Oxidoreductases and a part of 2nd
complex of
ETC
I have an isoalloxazine ring
I’m a derivative of Warburg’s yellow enzyme
I can produce 2 ATP in ETC
6

51. Abstract Slide 3
SCORE??

52. Rapid fire round

53. 1
1) Name an ectoenzyme
2) Reference range of cholesterol
3) Alpha1 antitrypsin is an acute phase protein T/F
4) Primary structure of protein contains sulfide
bridges- T/F
5) Cyanide inhibits which complex of ETC?
6) What is the DNA repair defect in Xeroderma
pigmentosa?

54. 2
1) Reference range of AST?
2) Bile salts appear in urine in hemolytic jaundice- T/F
3) Which fraction of HDL-C is bad cholesterol?
4) How much is SDA of protein?
5) Lac Y codes for which enzyme?
6) Iodine number measures--

55. 3
1) UGA codes for which amino acid?
2) Collagen triple helix has secondary protein structure- T/F?
3) Phrynoderma is a condition seen due to deficiency of?
4) Reference range of serum calcium?
5) Schilling test is done to find out—
6) Most effective blood buffer is--

56. 4
1) RDA of thiamine (Vitamin B1)?
2) pH of urine is acidic in respiratory acidosis- T/F?
3) Leukotrienes are synthesised by which pathway?
4) What is translocation in translation process?
5) Statin group of drugs inhibit which enzyme?
6) First purine to be produced is--

57. Abstract Slide 4
FINAL SCORE???

58. Instructional Slide Identify the chart

59. •A child presents with failure to thrive, steatorrhea, and ataxia.
Peripheral smear shows acanthocytes. Serum LDL and chylomicrons
are undetectable. Identify the disorder and explain the lipid
abnormality.
•Which is the most common epigenetic mechanism?
Thank you !!!

60. MetaboLogic
Biochemistry Quiz 2025
This is to certify that Mr/Ms------------------------------------------------------participated and won
--------------------------------------position in “MetaboLogic”, Biochemistry Quiz competition
conducted on Dt. 28.06.2025 at KIMS, Bhubaneswar.
Organizing Chairman
Prof. Tapaswini Pradhan
HOD Biochemistry
Organizing Secretary
Prof. Viyatprajna Acharya
Principal
AVM Prof. R.C. Das