This document discusses lessons learned from managing a large WordPress multisite network with over 8,500 sites and 77,000 users. Key points include how to setup and install multisite quickly, pros and cons to consider, when multisite is a good fit, and challenges of supporting a very large network at a university including infrastructure, selecting plugins and themes, ongoing security, and tools used for monitoring, debugging and version control. Managing a large multisite installation requires keeping things simple and scalable as well as thinking long term about how design decisions will impact the network over time.