Aspirin is the common name for acetylsalicylic acid, a drug in the salicylate group. It is synthesized from salicylic acid using acetic anhydride. Aspirin is used to treat or prevent heart attacks, strokes, and chest pain. It works by reducing the production of prostaglandins, which are pain-triggering hormones. Potential side effects include stomach bleeding, swelling, hearing problems, and headaches.

1. NAVEED HASSAN.
ABDUL GHAFOOR.
SANTOSH KUMAR.
GROUP 13

2. Its chemical name is 2-Acetoxybenzoic acid.
Also called as Acetylsalicylic acid. Aspirin is in a group
of drugs called salicylates.

3. ASPIRIN SYNTHESIS
OH
OH
O
salicylic acid
O
O O
acetic anhydride
O
OH
O
O
acetyl salicylic acid (aspirin)
OH
O
acetic acid
H2SO4
heat
+ +

4. PHYSICAL PROPERTIES
 Physical State: crystalline
 Appearance: white
 Odor: odorless
 Nature: Aromatic and acidic
 pH: 3.5
 Melting Point: 136°C
 Solubility: in organic solvents.
 Specific Gravity/Density:1.350
 Molecular Formula:C9H8O4
 Molecular Weight:180.16

5. FUNCTIONAL GROUPS IN ASPIRIN
 It contain one benzene ring with carboxyl
group as well as acetyl group.
 That’s why it is acidic in nature.

6. Important information about
aspirin
 Aspirin is used to treat or prevent heart attacks, strokes,
and chest pain (angina).
 It is also used as pain killer.
 Aspirin should not be given to a child who has a fever,
especially if the child also has flu symptoms or chicken
pox. Aspirin can cause a serious and sometimes fatal
condition called Reye's syndrome in children.
 Avoid drinking alcohol while you are taking this
medication. Alcohol may increase your risk of stomach
bleeding.

7. HOW ASPIRIN WORKS
• Aspirin works by reducing the production of
prostaglandins. Prostaglandins are pain-triggering
hormones. It produces pains like headaches etc.
Aspirin, sticks to COX-2 (Cyclooxygenase 2 enzyme)
to suppress pain. COX-2 is a protein made by your
body's cells whose job is to take chemicals floating
around in your tissues and turn them into
prostaglandins

8. Before taking aspirin
 Do not use this medication if you are allergic to aspirin,
or if you have:
 a recent history of stomach or intestinal bleeding;
 a bleeding disorder such as hemophilia; or
 stomach ulcers;
 liver disease;
 kidney disease;
 a bleeding or blood clotting disorder;
 heart disease, high blood pressure, or heart failure;

9. ASPIRIN SIDE EFFECTS
 swelling, or pain lasting longer
than 10 days; or
 hearing problems, ringing in
your ears.
 Less serious side effects may include:
 upset stomach, heartburn;
 headache.

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