Salicylic acid is a phenolic compound found naturally in plants like willow trees. It was first isolated from willow bark in 1828. Salicylic acid has various physiological roles in plants and derivatives like aspirin and sulfasalazine are used as medications in humans. Aspirin is an analgesic and antipyretic used to reduce fever and pain. It works by inhibiting platelet aggregation. Sulfasalazine is a disease-modifying anti-rheumatic drug used to treat rheumatoid arthritis and inflammatory bowel diseases by reducing inflammation. Both drugs are derivatives of salicylic acid and have anti-inflammatory properties.