Ventilator-associated pneumonia (VAP) is a common nosocomial infection that occurs in mechanically ventilated patients. It is associated with high morbidity and mortality. The diagnosis of VAP has traditionally been challenging due to non-specific clinical signs. Bronchoscopic techniques like protected specimen brushing and bronchoalveolar lavage have improved specificity in diagnosing VAP. Implementing a VAP bundle that includes interventions like elevating the head of bed, oral care, and sedation vacations can effectively prevent VAP. Empiric antibiotics should be started immediately for suspected VAP and later tailored according to culture results.