Timers 2, 4, and 6 of PIC18 microcontrollers are 8-bit timers that use a prescaler to divide the clock source frequency. They increment until they reach the value in the period register, then reset to 0 and trigger an interrupt. The interrupt can be further divided by a programmable postscaler value between 1 and 16. These timers provide a method of generating periodic interrupts for tasks like PWM or software timing in PIC18 microcontrollers.