Use of bioactive compounds for treating cancer
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1. Nutraceuticals are food or food components that provide health benefits for treating or preventing disease. They include vitamins, minerals, herbs, probiotics, and other dietary supplements.
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3. A study developed a probiotic pomegranate beverage using lactic acid bacteria strains. Treatment with L. acidophilus showed highest total phenols and antioxidant activity over the storage period. The beverage provides benefits of pomegranate with enhanced probiotic
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This document discusses various antioxidant-rich beverages and their health benefits. It begins by explaining what antioxidants and free radicals are, and how antioxidants protect the body from free radical damage. It then examines several beverages - green tea, black tea, herbal tea, coffee, red wine, pomegranate juice, and various berry juices. Each beverage is highlighted for its specific antioxidants and associated health benefits, such as improving heart health, boosting immunity, reducing inflammation, and protecting against cancer and aging. The document emphasizes that consuming antioxidant-rich beverages can help maintain a balance between free radicals and antioxidants in the body.
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anti-inflammatory
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After completing a Master of Science in Health Communication from Boston University, I became extremely interested in researching the health benefits of certain foods, and I wanted to share my findings with the world. I also wanted to explore the creativity and joy of cooking, an art that many people have abandoned in today’s fast-paced, fast food world. Having also a background in art, I decided to call my revival of the kitchen and the art of cooking “The Kitchaissance,” like the Renaissance of the kitchen. I hope you will subscribe to receive healthy, vegetarian recipes, articles on healthy ingredients and nutrition, cookware recommendations, and more!
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MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
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Use of bioactive compounds for treating cancer
- 1. BIOACTIVE COMPOUNDS & CANCER Use of bioactive compounds for treating cancer
- 2. Submitted to: MA’AM RAHEELA IJAZ Submitted by: MADIHA ASAD (L1S21BSBT0110) SAMEERA JAMIL (L1S21BSBT0089)
- 3. CONTENTS: INTRODUCTION. BIOACTIVE COMPOUNDS. THEIR ANTI-CANCEROUS EFFECTS.
- 4. Madiha Asad (L1S21BSBT0110) Introduction: Bioactive compounds Cancer Nutrigenomics
- 5. BIOACTIVE COMPOUNDS: A type of chemical found in small amounts in plants and certain food. “Bioactive compounds are extranutritional constituents that typically occur in small quantities in foods and promote good health." Example: Lycopene, resveratrol, lignin, tannis and indoles. [6,7,8]
- 7. CANCER Cancer is a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body. [9]
- 8. [5]
- 9. Nutrigenomics studies the modulating effect of the chemical compounds in foods and on the stability of DNA synthesis and gene expression. The nutrients are able to affect the genome and its expression By the synthesis of nucleotides prevention and repair of DNA damage By epigenetic mechanisms (methylation of histones, proteins responsible for chromatin structure that play an important role in regulating gene expression. [4]
- 10. Many bioactive compounds have been discovered. These compounds vary widely in chemical structure and function and are grouped accordingly.
- 11. Bioactive compounds Examples Sources Supposed anticancer effects Polyphenolic compounds Quercetin, resveratrol, catechin Red wine, chocolate, flaxseed oil Carcinogen detoxification, inhibit tumor initiation/promotion, antimutagen Carotenoids Lycopene, lutein, cryptoxanthin Tomatoes, carrots, leafy vegetables Antimutagen Sulfur-Containing compounds Allicin, diallyl sulfide, allyl mercaptan Sulforaphane Garlic, onion, leek Carcinogen detoxification, inhibit tumor initiation/promotion Terpenoid Perillic acid, d-limonene Cherries, mint, herbs Carcinogen detoxification, inhibit
- 12. Poly-Phenolic compounds: Polyphenolic compounds are a diverse group of natural compounds with multiple phenolic functions. Occurrence: In plants. Roles: • Protection against cardiovascular disease. • Metabolic dysfunction & aging. • Anticarcinogenic
- 13. The polyphenols from food occur in forms; Polymers. Esters. Glycosides. Pathway: Polyphenols hydrolyzed by microbes (enter the body) absorbed
- 14. Polyphenols are also involved in methylation sulfation glucuronidation Factors affecting activity of phenols are rate of; Metabolism. Absorption. Elimination. Points to discuss; Hepatic activity Dietary phenols and their function [1]
- 15. Polyphenolic compounds Sources Examples Flavonoids Chocolate, red wine, tea, apple, onions, broccoli, olives Flavonols, isoflavonoids, anthocyanidins, Phenolic acids Coffee, black tea, cereals Benzoic acid, cinnamic acid Stilbenes Grapes, peanuts, red wine Resveratrol Lignans Flaxseed oil, clover, lucerne Secoisolariciresinol, matairesinol [2]
- 16. Flavonoids: flavonoids are sub-class of polyphenols recognized for their low molecular weight. Abundaces: 1. Tea. 2. Chocolate 3. Plants (fruits flowers)
- 18. Sameera Jamil (L1S21BSBT0089) Other Types Of Bioactive Compounds
- 19. Non-flavonoid Compounds: 1. Resveratrol (stilbene family) (Antioxidant & Anticarcinogenic) 2. Lignans (arctigenin, magnolol & honokiol) (inc. level of anti [oxidant & inflammatory] and carcinogen-deactivating enzymes. [1,6,7]
- 20. 3. Phenolic acids (antiproliferative and proapoptic effects) Types: Hydroxybenzoic acid. Hydroxycinnamic acid. [1] Magnolol (colorectal cancer prevention) Honokiols (prevent pancreatic cancer)
- 21. Carotenoids (tetrapene family): Abundant in fruits and vegetables. It includes carotene, lycopene, lutein and cryptoxanthin Pathway: carotenoids decrease in size absorption (by bile salts in intestine) (in enterocytes) [1,7]
- 22. Sulfur-Containing Compounds: (biosynthesis of secondary metabolites & protection against stimuli) It includes; 1. Glutathione 2. L-cysteine 3. L-glutamic acid 4. glycine [1,6,7]
- 23. Terpenoid: Most abundant secondary metabolites. Largest compounds. Derived from mevalonic acid containing; five carbon isoprene units [1,6]
- 24. Other Compounds with Anticancer Effect: Dietary fibers. Vitamin C. Vitamin D. Melatonin. [1,7]
- 25. References: 1. https://www.hindawi.com/journals/omcl/2022/1429869/ 2. https://www.hindawi.com/journals/omcl/2022/1429869/tab3/ 3. https://www.hindawi.com/journals/omcl/2022/1429869/tab2/ 4. https://www.intechopen.com/chapters/44354 5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995630/ 6. https://pubmed.ncbi.nlm.nih.gov/12566142/ 7. https://www.amjmed.com/article/S0002-9343(01)00995-0/fulltext 8. https://www.cancer.gov/publications/dictionaries/cancer- terms/def/bioactive-compound 9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564139/