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Seminar
FEMALE Urethral diverticula
- Dr. Abhishek Pandey
Introduction
• Female Urethral Diverticulum (UD) –
– Urine-filled periurethral cystic structure
– Within the confines of pelvic fascia
– Connected to urethra via an ostium
• 1-6% prevalence in adult females
• Diagnostic & reconstructive challenge
• Modern era of female UD began in 1950’s – Positive
pressure urethrography (PPU) by Davis & Cian
Anatomy
• Female Urethra – 4cm musculofascial tube
• Urethropelvic ligament – supports urethra & bladder
neck to lateral pelvic wall (ATFP)
• Two layers of fused pelvic fascia extending bilaterally
– Endopelvic fascia – abdominal side
– Periurethral fascia – vaginal side (extension of pubocervical
fascia)
– Within these two leaves lie the urethra & UD
Periurethral Glands
• Periurethral glands – Tubuloalveolar glands
– Within the vascular lamina-propria/submucosa
– exist over entire urethra posterolaterally
– most prominent over distal two thirds
– majority glands draining into distal third urethra
• Skene glands – largest & most distal glands draining
outside lumen,
lateral to urethral meatus
Pathogenesis
• Infectious etiology – involving periurethral glands
• Young (1996) – Modern hypothesis of UD pathogenesis
– Repeated infection-obstruction of periurethral glands
– Cavity expansion → disrupt urethral muscles
– Herniation into urethropelvic ligament
– Expansion m/c ventrally → classic anterior vaginal wall
mass
– Cavity ruptures into urethral lumen → Ostia formed
Associated Pathology
• 10% case – premalignant & malignant changes
• m/c malignancy – Adenocarcinoma
• Calculi within UD – 4-10% cases
• Multiple UD – 6% cases
• Varying degrees of
sphincteric compromise
Variable Morphology
Simple Diverticulum Saddlebag Diverticulum
Circumferential Diverticulum Diverticular Ostium
Presentation
• b/w 3rd & 7th decades of life
• Classic presentation – “three Ds” —dysuria, dyspareunia
& dribbling (postvoid) – 20-25%
• Highly variable presentation – Diagnostic challenge
• 1/3rd cases – Incontinence (UD-1.4% UI cases)
• Upto 20% may be completely Asymptomatic
• Size of UD does not correlate with symptoms
• Waxing & wanimg of symptoms over long durations
Cystourethroscopy
Bladder neck compression during urethroscopy
facilitates urethral distension & direct observation
Urethroscope – 15° Lens with inflow at
the same level as lens – facilitates direct
urethral observation and distension
• UD ostium – m/c posterolaterally at 4 & 8 o’clock
positions at level of mid-urethra
• Variable success in identifying ostium – 15-90%
• Evaluate other causes of LUTS
• Compression of UD sac –
discharge in urethra
O – UD ostium of a UD
L – Lumen of urethra
UDS
• 1/3rd patients present with urinary incontinence
• 50% of women with UD will have SUI on UDS
• Urethral pressure profilometry (UPP) –
– continuous measurement of fluid pressure needed
to just open a closed urethra
– Biphasic pattern – pressure
drop at the level of lesion
Positive Pressure Urethrography (PPU)
• Double balloon PPU
• Trattner catheter
• Historical importance
MCU
• Sensitivity – 44-95%
• Voiding required to visualize (patient may not)
• MCU with no post-void image – non-diagnostic
• Inability to generate adequate flow rate during MCU
– Results in suboptimal filling of UD
– Underestimation of size & complexity
MRI
Surface coil MRI
Endoluminal (vaginal coil) MRI
Direct contrast injection in anterior vaginal wall mass – Imaging UD
Differential
diagnoses
Management
Surgical Procedures
• Hey (1805) first described Transvaginal incision with
packing of UD cavity with lint
• Transurethral Procedures –
– Marsupialisation
– Endoscopic unroofing
– Fulguration
– Incision & obliteration with oxidised cellulose /
PTFE
• Transvaginal Procedures –
– Spence–Duckett procedure – UD marsupialized into
vagina (very distal UD)
– Excision and Reconstruction
• Current - Excision and Reconstruction
Principles of Transvaginal Urethral Diverticulectomy
• Well-vascularized anterior vaginal wall flaps
• Preservation of periurethral fascia
• Identification & excision of neck / ostium
• Removal of entire UD wall or sac (mucosa)
• Watertight urethral closure
• Multilayer, nonoverlapping closure – absorbable
suture
• Closure of dead space
• Preservation or creation of continence
Importance of preserving & reconstructing the periurethral fascia
Complications
Thank You
A
• A

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Urethral diverticulum

  • 2. Introduction • Female Urethral Diverticulum (UD) – – Urine-filled periurethral cystic structure – Within the confines of pelvic fascia – Connected to urethra via an ostium • 1-6% prevalence in adult females • Diagnostic & reconstructive challenge • Modern era of female UD began in 1950’s – Positive pressure urethrography (PPU) by Davis & Cian
  • 3. Anatomy • Female Urethra – 4cm musculofascial tube • Urethropelvic ligament – supports urethra & bladder neck to lateral pelvic wall (ATFP) • Two layers of fused pelvic fascia extending bilaterally – Endopelvic fascia – abdominal side – Periurethral fascia – vaginal side (extension of pubocervical fascia) – Within these two leaves lie the urethra & UD
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. Periurethral Glands • Periurethral glands – Tubuloalveolar glands – Within the vascular lamina-propria/submucosa – exist over entire urethra posterolaterally – most prominent over distal two thirds – majority glands draining into distal third urethra • Skene glands – largest & most distal glands draining outside lumen, lateral to urethral meatus
  • 9.
  • 10. Pathogenesis • Infectious etiology – involving periurethral glands • Young (1996) – Modern hypothesis of UD pathogenesis – Repeated infection-obstruction of periurethral glands – Cavity expansion → disrupt urethral muscles – Herniation into urethropelvic ligament – Expansion m/c ventrally → classic anterior vaginal wall mass – Cavity ruptures into urethral lumen → Ostia formed
  • 11.
  • 12.
  • 13. Associated Pathology • 10% case – premalignant & malignant changes • m/c malignancy – Adenocarcinoma • Calculi within UD – 4-10% cases • Multiple UD – 6% cases • Varying degrees of sphincteric compromise
  • 14. Variable Morphology Simple Diverticulum Saddlebag Diverticulum Circumferential Diverticulum Diverticular Ostium
  • 15. Presentation • b/w 3rd & 7th decades of life • Classic presentation – “three Ds” —dysuria, dyspareunia & dribbling (postvoid) – 20-25% • Highly variable presentation – Diagnostic challenge • 1/3rd cases – Incontinence (UD-1.4% UI cases) • Upto 20% may be completely Asymptomatic • Size of UD does not correlate with symptoms • Waxing & wanimg of symptoms over long durations
  • 16.
  • 17. Cystourethroscopy Bladder neck compression during urethroscopy facilitates urethral distension & direct observation Urethroscope – 15° Lens with inflow at the same level as lens – facilitates direct urethral observation and distension
  • 18. • UD ostium – m/c posterolaterally at 4 & 8 o’clock positions at level of mid-urethra • Variable success in identifying ostium – 15-90% • Evaluate other causes of LUTS • Compression of UD sac – discharge in urethra O – UD ostium of a UD L – Lumen of urethra
  • 19. UDS • 1/3rd patients present with urinary incontinence • 50% of women with UD will have SUI on UDS • Urethral pressure profilometry (UPP) – – continuous measurement of fluid pressure needed to just open a closed urethra – Biphasic pattern – pressure drop at the level of lesion
  • 20. Positive Pressure Urethrography (PPU) • Double balloon PPU • Trattner catheter • Historical importance
  • 21. MCU • Sensitivity – 44-95% • Voiding required to visualize (patient may not) • MCU with no post-void image – non-diagnostic • Inability to generate adequate flow rate during MCU – Results in suboptimal filling of UD – Underestimation of size & complexity
  • 22.
  • 25. Direct contrast injection in anterior vaginal wall mass – Imaging UD
  • 28. Surgical Procedures • Hey (1805) first described Transvaginal incision with packing of UD cavity with lint • Transurethral Procedures – – Marsupialisation – Endoscopic unroofing – Fulguration – Incision & obliteration with oxidised cellulose / PTFE
  • 29. • Transvaginal Procedures – – Spence–Duckett procedure – UD marsupialized into vagina (very distal UD) – Excision and Reconstruction • Current - Excision and Reconstruction Principles of Transvaginal Urethral Diverticulectomy • Well-vascularized anterior vaginal wall flaps • Preservation of periurethral fascia
  • 30. • Identification & excision of neck / ostium • Removal of entire UD wall or sac (mucosa) • Watertight urethral closure • Multilayer, nonoverlapping closure – absorbable suture • Closure of dead space • Preservation or creation of continence
  • 31.
  • 32.
  • 33. Importance of preserving & reconstructing the periurethral fascia

Editor's Notes

  1. T2-w MR images demonstrates a high-signal-intensity central zone (C) representing luminal urine or secretions, a low-signal-intensity inner mucosal layer (I) representing epithelial cells, a high-signal-intensity middle submucosal layer (M) representing vascularized connective tissue, and a low-signal-intensity outer muscular layer (O) representing smooth muscle.