NOF FRACTURE EASIEST SLIDE, EASY TO KNOW THE RECENT ADVANCES IN THE FIELD OF NOF, INCLUDING THE CASE WHICH WAS MANAGED IN DHULIKHEL HOSPITAL AND ASSOCIATED COMPLICATION THAT HAS ARISED ALONG WITH THE MANAGEMENT OF THE COMPLICATION
NOF FRACTURE EASIEST SLIDE, EASY TO KNOW THE RECENT ADVANCES IN THE FIELD OF NOF, INCLUDING THE CASE WHICH WAS MANAGED IN DHULIKHEL HOSPITAL AND ASSOCIATED COMPLICATION THAT HAS ARISED ALONG WITH THE MANAGEMENT OF THE COMPLICATION
1) Subtrochanteric Fracture
Subtrochanteric typically defined as area from lesser trochanter to 5cm distal fractures with an associated intertrochanteric component may be called peritrochanteric fracture.
*Unique Aspect
Blood loss is greater than with femoral neck or trochanteric fractures – covered with anastomosing branches of the medial and lateral circumflex femoral arteries branch of profunda femoris trunk.
2) Femoral Shaft Fracture
Femoral shaft fracture is defined as a fracture of the diaphysis occurring between 5 cm distal to the lesser trochanter and 5 cm proximal to the adductor tubercle
The femoral shaft is padded with large muscles.
- reduction can be difficult as muscle contraction displaces the fracture
- healing potential is improved by having this well-vascularized
*Age
-usually a fracture of young adults and results from a high energy injury
-elderly patients should be considered ‘pathological’ until proved otherwise
-children under 4 years the suspected possibility of physical abuse
*FRACTURES ASSOCIATED WITH VASCULAR INJURY
Warning signs of an associated vascular injury are
(1) excessive bleeding or haematoma formation; and
(2) paraesthesia, pallor or pulselessness in the leg and foot.
~Warm ischemia in 2-3H
~If > 6H – salvage not possible
*‘FLOATING KNEE’
Ipsilateral fractures of the femur and tibia may leave the knee joint ‘floating’
3) Distal Femoral Fracture
Defined as fractures from articular surface to 5cm above metaphyseal flare
*clinical feature
The knee is swollen because of a haemarthrosis – this can be severe enough to cause blistering later
Movement is too painful to be attempted
The tibial pulses should always be checked to ensure the popliteal artery was not injured in the fracture.
Reference: Apley's System of Orthopaedic and Fracture (9th edition)
Similar to Upper extremity (shoulder fracture (20)
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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3. AO
classification
Type A: extra-articular unifocal (either tuberosity +/- surgical
neck of the humerus)
•A1: extra-articular unifocal fracture
•A2: extra-articular unifocal fracture with impacted metaphyseal fracture
•A3: extra-articular unifocal fracture with non-impacted metaphyseal fracture
Type B: extra-articular bifocal (both tuberosities +/- surgical
neck of the humerus or glenohumeral dislocation)
•B1: extra-articular bifocal fractures with impacted metaphyseal fracture
•B2: extra-articular bifocal fractures with non-impacted metaphyseal fracture
•B3: extra-articular bifocal fractures with glenohumeral joint dislocation
Type C: extra-articular (anatomical neck) but with compromise
to the vascular supply of the articular segment
•C1: anatomical neck fracture, minimally displaced
•C2: anatomical neck fracture, displaced and impacted
•C3: anatomical neck fracture with glenohumeral joint dislocation
4. Neer classification
• Based on anatomic relationship of 4 segments
• Greater tuberosity
• Lesser tuberosity
• Articular surface
• Shaft
• Considered a separate part if
• Displacement of > 1 cm
• 45° angulation
5.
6. NEER
Classification
Fracture lines involve 1-4 parts
None of the parts are displaced (i.E <1 cm and <45
degrees)
One-part
fracture
Fracture lines involve 2-4 parts
One part is displaced (i.E >1 cm or >45 degrees)
Two-part
fracture
Fracture lines involve 3-4 parts
Two parts are displaced (i.E >1 cm or >45 degrees)
Three-part
fracture
Fracture lines involve more than 4 parts
Three parts are displaced (i.E., >1 cm or >45 degrees) with
respect to the 4th
Four-part
fracture
10. • Findings
• Combined cortical thickness (medial +
lateral thickness >4 mm)
• Studies suggest correlation with
increased lateral plate pullout strength
• Pseudosubluxation (inferior humeral head
subluxation) caused by blood in the
capsule and muscular atony
11. CT scan
• CT scans are not necessary for all proximal humerus fractures, especially if minimally displaced.
• They can be very helpful for assessing complex injuries, particularly involving the humeral head,
or with significant comminution.
• CT scans aid assessment of:
• Fracture morphology (including the number of fragments)
• Bone stock of the tuberosities and humeral head fragment
• Degree of comminution
• Size of fixable fragments
• Length of posteromedial metaphyseal extension
13. Surgical Indication
• CRPP (closed reduction percutaneous pinning)
• Indications
• 2-part surgical neck fractures
• 3-part and valgus-impacted 4-part fractures in patients with good
bone quality, minimal metaphyseal comminution, and intact medial
calcar
• Outcomes
• Considerably higher complication rate compared to ORIF, HA, and RSA
• Axillary nerve at risk with lateral pins
• Musculocutaneous nerve, cephalic vein, and bicep tendon at risk
with anterior pins
14. ORIF
•Indications
•Greater tuberosity displaced > 5mm
•Displaced 2-part fractures
•3-, and 4-part fractures in younger patients
•Head-splitting fractures in younger patients
•Outcomes
•Medial support necessary for fractures with
posteromedial comminution
•Consider use of a fibula strut if concerned about
medial support or bone quality
•Calcar screw placement critical to decrease varus
collapse of head
15. Intramedullary
nailing
• Indications
• Surgical neck fractures or 3-part
greater tuberosity fractures in
younger patients
• Combined proximal humerus and
humeral shaft fractures
• Outcomes
• Biomechanically inferior with
torsional stress compared to plates
• Favorable rates of fracture healing
and ROM compared to ORIF
16. Arthroplasty
Indications
• Hemiarthroplasty
• In younger patients (40-65 years old) with complex fracture-
dislocations or head-splitting components that may fail fixation
• Recommended use of convertible stems to permit easier conversion
to RSA if necessary in future
• Reverse total shoulder
• Low-demand elderly individuals with non-
reconstructible tuberosities and poor bone stock
• Older patients with fracture-dislocation
17. Arthroplasty
Outcomes
• Improved results if
• Anatomic tuberosity reduction and healing
• Restoration of humeral height and version
• Humeral height is best judged from the superior border of
the pectoralis major insertion
• Poor results with
• Tuberosity nonunion or malunion
• Retroversion of humeral component > 40°
18. Clavicle Fracture Classification
• Clavicle Shaft Fracture
Allman Classification
Type I Middle third (most common)
Type II
Distal to the
coracoclavicular ligaments
(lateral 1/3)
Type III Proximal (medial) third
27. Radiologic Parametric
• upright AP of bilateral shoulders
• axillary lateral
• 15° cephalic tilt (zanca view)
• helps to determine superior/inferior displacement
28. Surgical Indication
• Closed reduction and intramedullary fixation vs. open
reduction internal fixation
• Absolute indication
• Open fractures
• Displaced fractures with skin tenting
• Subclavian artery or vein injury
• Floating shoulder
• Symptomatic nonunion
• Symptomatic malunion
29. Surgical Indication
• Closed reduction and intramedullary fixation vs. open
reduction internal fixation
• Relative and controversial indications
• Displaced with >2 cm shortening
• bilateral displaced clavicle fractures
• brachial plexus injury (questionable because 66% have spontaneous
return)
• closed head injury
• seizure disorder
• polytrauma patient
30. Scapular Fracture Classification
Classification is based on the location of the fracture and includes
• coracoid fractures
• acromial fractures
• glenoid fractures
• scapular neck fractures
• look for associated AC joint separation or clavicle fracture
• known as "floating shoulder"
• scapular body fractures
• described based on anatomic location
• scapulothoracic dissociation
36. open reduction internal fixation
•Indications
•glenohumeral instability
• > 25% glenoid involvement with subluxation of humerus
• > 5mm of glenoid articular surface step off or major gap
• excessive medialization of glenoid
•displaced scapula neck fx
• with > 40 degrees angulation or 1 cm translation
•open fracture
•loss of rotator cuff function
•coracoid fx with > 1cm of displacement
•"double disruption" of the superior shoulder suspensory complex
41. Surgical Indication
• CC interval restoration (ORIF vs. Ligament Reconstruction)
• Indication
• acute type IV, V or VI injuries
• acute type III injuries in laborers, elite athletes, patients with cosmetic
concerns
• chronic type III injuries that failed non-op treatment
• Contraindication
• patient unlikely to comply with postoperative rehabilitation
• skin problems over fixation approach site