This document provides information on proximal humerus fractures, including:
1. The anatomy of the proximal humerus and forces that cause deformity.
2. Classification systems for proximal humerus fractures including Neer's classification.
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fractures of the proximal humerus are among the most common fractures of the upper limb and management options are wide according many variables mostly the age.
fractures of the proximal humerus are among the most common fractures of the upper limb and management options are wide according many variables mostly the age.
it comprises of the anatomy, epidemiology, mechanism of injury and management options.
there is also the fracture classifications
management was grouped into operative and conservative
there is also a section for children.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
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combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
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Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
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- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
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- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
3. • Proximal humerus comprises of four
major segments
• The Articular head
• The greater tuberosity
• Lesser tuberosity and
• The shaft
• Articular segment almost spherical, with a
diameter of curvature averaging 46 mm
(ranging from 37 to 57 mm)
• Humeral head shaft angle : 130 degrees
• Retroversion of the head : 18 to 40 deg
6. • The ascending branch of the anterior
circumflex humeral artery has been considered
to provide most of the blood flow to the articular
segment.
• Several studies have shown branches from
PCHA to the posteromedial head to be equally
important.
• Arcuate artery of Liang – supplies Humeral
head.
• If the medial calcar of the humerus is spared
by the fracture, the vessel is spared.
10. • Muscle insertions on these segments and the
magnitude and direction of the forces causing
injury determine the pattern of fracture lines
,displacement and angulation.
• Greater tuberosity : supraspinatus,
infraspinatus & teres minor insertion.
• Lesser tuberosity : Subscapularis muscle
insertion.
LT separated from the GT by BICIPITAL
GROOVE
11. ROTATOR INTERVAL
• Triangular space b/w the
tendons of supraspinatus
and subscapularis and the
base of coracoid process
• contents : corocohumeral
and superior glenohumeral
ligament ( key role in
shoulder stability )
13. • Defined as Fx occurring at or proximal to
surgical neck of humerus.
• 80 % of all humeral # and 7% of all #..
• Pt > 65 yrs – Second most common
fracture of the upper extremity
• 65% of # occur in Pt’s > 60 yrs
• F:M – 3:1
• Incidence increases with age.
14. Mechanism :
• Old Pts low energy trauma. [FOOSH]
• Young Pts – High energy trauma
• Most # are nondisplaced, good prognosis –
nonsurgical
• Risk factors: osteoporotic bone ,impaired
vision & balance, medical comorbidities,
decreased muscle tone and Seizures &
electric shock (indirect causes)
• Severe soft tissue disruption always
require surgical intervention
15.
16.
17. DEFORMING FORCES ON
FRACTURE FRAGMENTS
• The greater tuberosity
pulled posteromedially by
the effect of the supra- and
infraspinatus tendon.
• The lesser tuberosity
pulled anteriorly by the
subscapularis tendon.
• The shaft segment pulled
anteromedially by the
pectoralis major tendon.
18. Clinical Evaluation :
• A complete history and physical
examination must be obtained about the
mechanism of injury and velocity of
fracture.
• Shoulder pain and limitation of
movement.
• Ecchymosis appears within 24-48 hrs.
• Look for rib, scapular, cervical # in high
energy trauma.
19. • Concurrent brachial plexus injury 5%
• Axillary nerve susceptible in anterior #
dislocation.
• Association of arterial injury rare.
• The patient will hold the arm in internal
rotation.
• Radial pulse and capillary refill of fingers
should be assessed
20. Imaging and other Diagnostic studies :
• Radiographs :- consist of three views :
• AP- Perpendicular to the plane of scapula(Grashey view)
Taken in neutral arm rotation with torso rotated 30 to 45
degrees
• Neer view : Scapula imaged perpendicular to Grashey view
(scapular y view )
• Axillary view : Arm in neutral rotation and abducted as much
as possible, with the pt. supine and X-ray beam projected
from axilla.
25. SCAPULAR Y VIEW
• In acute trauma to evaluate for anterior and
posterior dislocations
• Fractures of coracoid process, scapula, acromion
process,proximal humeral shaft.
AXILLARY VIEW :
• For evaluating anterior and posterior glenohumeral
subluxation or dislocation.
• Helpful in detection of osseous bankart Lesion .
29. CT Scan :
Allows more detailed understanding of fracture
configuration, degree of osteopenia, presence and location
of bone impaction and extent of fracture comminution.
• MRI - Is rarely indicated in trauma setting.
• Angiography : Vascular imaging is required when there is
suspicion of vascular injury.
• CT Angiography- Diagnostic modality of choice.
It allows rapid evaluation of vascular system, while
simultaneously allowing assessment of bone and soft
tissues.
30.
31.
32. Proximal Humeral Fracture
Classfication- Neer’S Classification
(1970)
• REFINEMENT OFCODMAN’S SYSTEM.
• BASED ON ANATOMICAL,BIOMECHANICAL AND
DEGREE OF DISPLACEMENT .
• TWO MAIN COMPONENTS :
1.number of fracture parts { humeral
head,GT,LT,shaft }
2.displacement { angulation > 45 deg or
displacement>1 cm }
• Classified as One part, Two part, Three Part and Four
part Fractures.
33.
34. Valgus-Impacted Four-Part Fractures :
• Neer added this pattern as a separate category in 2002
.
→The head rotated into a valgus posture and driven
down between the tuberosities, which splay out to
accommodate the head.
→ Unlike in the classic four-part fracture, the articular
surface maintains contact with the glenoid.
36. • Fracture Dislocation :
Fractures combined with glenohumeral
dislocation are classified as fracture dislocation.
• Articular surface injuries :
Fractures involving articular surface can be of
two varieties-
1. head-splitting fractures
2. impaction fractures.
They are included in group of fracture dislocations.
37. Risk of Avascular Necrosis
Highest risk for humeral head ischaemia & necrosis :
1.Four-part fractures
2.Fracture dislocations
Hertel’s criteria
1. Metaphyseal extension of the humeral head > 9
mm
2. Medial hinge disruption of >2 mm, and
3. Fracture through anatomical neck .
• The combination of above factors had 97% positive
predictive value for humeral head ischemia.
38. MANAGEMENT :
NON-OPERATIVE TREATMENT FOR
1.undisplaced or minimally displaced.
2.stable fractures.
3.elderly patients
4.patient unfit for surgery
5.four part valgus impacted fracture
6.poor bone quality.
40. CONSERVATIVE MANAGEMENT :
• Shoulder immobilised for 4 to 6 weeks .
• Using cuff and collar ,Gilchrist or Velpeau
shoulder immobilizer .
• Regular follow up with radiographs
• Codman pendulum exercises
Passive ROM at 3 weeks
Active ROM at 6 weeks
Strengthening exercises at 12 weeks
according to radiographic and clinical healing
.
43. DASH
• Disabilities of the Arm, shoulder, and Hand
scale [ DASH ]
• Most widely used shoulder scale for
outcome assessment .
• Pt based , 6 domains {Daily activity ,
symptoms ,social Fn,Work Fn ,sleep,
confidence}.
• 30 questions and each question rated on a
likert scale 1 to 5 .
• Quick DASH - 11 questions
44. • DISPLACED 2-PART , 3 PART , 4 PART
- Closed reduction with percutaneous k-
wire fixation
- Proximal humerus locking
plate(phlp/philos)
- Tension band wiring
- Hemiarthroplasty
- Reverse total shoulder arthroplasty
45. FIXATION OF PHF USING PHILOS(3 PART
AND 4 PART)
-Principles of fixation
-Approaches
-Exposures
-Surgical steps
-Intraop image intensifier(c-arm)
46.
47.
48.
49. PHILOS PLATE :
• angular stable plate
• developed for combined rotational and
angular stability
• stabilize fracture without friction to bone
and plate so provides more stability to
osteoporotic bone
• has 12 suture holes and 9 screw holes
• calcar screws - obliquely positioned
inferomedial screws.
• reduces risk of varus collapse
• by counteracting the varus deforming
forces on humeral head
50. PRINCIPLES OF FRACTURE FIXATION
• If Bone quality adequate , Angular stable plate
offers potential function
• Anatomic ( stepless ) reduction of humeral head
and elimination of varus deformity.
• Proper stabilization of humeral head - for which
sufficient calcar screws are necessary to resist
varus deformity.
• Tension band sutures in addition to plate and
screws - increases stability particularly for more
communited and osteoporotic #
• Sutures placed through the insertional fibres of
tendon hold better than placed through bone.
51. APPROACHES :
• Deltopectoral approach (or) anterior approach .
• Anterolateral/acromial or deltoid splitting
approach.
POSITIONS :
1.Beach-chair position - hip at 45 deg and knee 30
deg bent.
2.Supine position in radiolucent table.
52.
53.
54. SURGICAL TECHNIQUES FOR ORIF OF
AN UNSTABLE DISPLACED 3 PART PHF
• for succesful reduction – 3 part converted to 2 part at the humeral
head i.e humeral articular part with the attached lt and gt
into 1 part with the shaft
4 steps
• surgical approach and axillary nerve identification
• long head of biceps tendon,rotator cuff suture and humeral head
assesment
• reduction with temporary k wire fixation and fluoroscopc assesment
• final fixation and suturing of rotator cuff to plate.
56. STEP 1
• supero lateral approach choosen
• provides greater access to gt , requires minimal soft
tissue dissection
• at first the deltoid is split between the anterior and
middle fibres in line with the skin incicsion
• axillary nerve lies in the deep layer of the deltoid
located 5cm below the acromian process
• to avoid the injury nerve is identified and looped
with umbilical tape.
57.
58. STEP 2
• Long head of biceps tendon is identified at the
bicipital groove .
• no 2 ethibond placed at Lt and GT to mobilise the
# fragments which assist with the reduction
• suture at Lt pulled laterally to correct retroversion
of the humeral head
• suture at Gt pulled into downward direction to
correct varus deformity
• subscapularis tendon attached to Lt should be
carefully protected to avoid avn of articular part.
59.
60. STEP 3
• the plate is placed 5mm lateral to the bicipital
groove
• 5-8mm below the tip of GT.
• k wire is used for temporary fixation of the
reduced 2 part # of the head with the aid of suture
traction
• a simple compression screw is placed at the oval
hole of the plate.
• plate is used to assist in reduction of the head and
shaft part
61.
62.
63.
64. STEP 4
• once the reduction is confirmed remaining
screws are placed at the head and shaft.
• calcar screws are placed supporting the reduced
calcar area.
• sutures attached to the rotator cuff are secured
to the plate holes.
65.
66. ADVANTAGES
• superolateral approach
gives greater access to
the # and gives minimal
dissection
• rotator cuff suturing
provides # segments
mobilisation
• articular frgament checked
by gloved index finger
• intra op flouroscopic
performed in refernce to
the phlp position rather
than patients position .
DISADVANTAGES
• not a true internervous
approach
• axillary nerve is at more
risk for injury
• cannot be used in 4 part
#(articular fragmnet lacks
control),impacted #s
because of bone loss.
• Anterior deltoid
dysfunction.
68. 4 STEPS
• Incision through deltopectoral approach
• Reduction and preliminary fixation
• Plate fixation
• Rotator cuff tendon suturing to the plate .
69. STEP 1 :
• Incision given from coracoid and extended
through deltopectoral groove
• Fascia cut
• Deltoid along retracted laterally pectoralis major
towards medially
• Coracobrachialis retracted to visualize
subscapular tendon
73. STEP 2 :
• Place rotator cuff sutures
• supraspinatus ,infraspinatus and subscapularis
• pull them and head split reduced using periostome
• preliminary k-wires are inserted into head through
gt
• shaft of humerus is fixed to the head using k-wires
placed anteriorly
• temporary reduction achieved
74.
75.
76.
77. STEP 3 :
• Attach plate to humeral shaft
• and fix the plate by passing a compression screw on the
shaft
• now make drill holes through drill sleeves into the humeral
head
• drill the near cortex only ,woodpecker drilling technique
• minimum of 5 screws placed
• check screw size under c-arm
• calcar screws are essential in all varus displaced fractures
78.
79.
80. STEP 4 :
• if needed , a lag screw can be inserted into
lesser tuberosity .
• additional shaft screws are inserted (bicortical
screws)
• Rotator cuff tendon sutures are placed through
the suture holes and secured { ↑ stability }
81.
82.
83.
84. INTRA OPERATIVE IMAGE
INTENSIFIER(C-ARM)
2 views
1) plate view :-
• arm is placed on an internally rotated position
• allows us to see the full profile of the plate
• plate should lie opposite and be centered over
the humeral head-should have light bulb
appearance.
86. 2) screw view :-
• it is the position in which articular surface
maximally purchased to the glenoid.
• arm is externally roatated to approximately
20-30degrees
87. HEMIARTHROPLASTY :
• Also known as Humeral Head Replacement .
• Indications :
1. unreconstructable humeral head
- comminuted head splitting #
- Head depression # involving >40 articular surface
2. biologic viability severely compromised .
• Hertel → # at anatomic neck of humerus had
increased risk of humeral head ischaemia .
• Glenoid erosion → delayed shoulder pain
88.
89.
90.
91.
92. REVERSE TOTAL SHOULDER
ARTHROPLASTY :
• Reverse total shoulder arthroplasty - Implant of
choice for the management of several conditions
significant rotator cuff dysfunction
rotator cuff tear arthropathy
massive irreparable rotator cuff tears with
painful pseudoparesis
Glenohumeral joint artritis with advanced
rotator cuff pathology .
Proximal humerus malunion / nonunion
• Alternative for management of acute complex
proximal humerus fractures .
93. • Most frequent complications of reverse total
shoulder arthroplasty - Glenoid notching