Ulcerative colitis is a chronic disease that causes inflammation and ulcers in the lining of the large intestine. The immune system mistakenly attacks healthy cells in the intestine. Symptoms include diarrhea, abdominal pain, and bloody stool. While the cause is unknown, genetic factors and the immune system are involved. A doctor can diagnose ulcerative colitis through medical history, exam, and tests. There is no known cure, but treatment aims to induce and maintain remission.