Ulcerative colitis is a type of inflammatory bowel disease that affects the lining of the large intestine and rectum, causing ulcers, bleeding, and diarrhea. The exact cause is unknown but may involve genetic and immune factors. Symptoms include abdominal pain, diarrhea, and rectal bleeding. The diagnosis is confirmed through endoscopy and biopsies of the colon. Treatment involves medications to reduce inflammation like aminosalicylates, corticosteroids, and immunomodulators. Surgery may be needed if medications are not effective.
I am professionally pharmacist. These slides for clinical based those students who study in pharmacy program. These students get more benefits about it.
I am professionally pharmacist. These slides for clinical based those students who study in pharmacy program. These students get more benefits about it.
Inflammatory Bowel Disease is a severe Case in which the peptic ulcers can forn in the bowel or it can cause an inflammation there.
This is Chronic type of disease and mainly target's and affecting the inner lining of GIT that Causes Prolonged inflammation to the GIT
Ulcerative colitis (UC) is an inflammatory bowel disease. It causes irritation, inflammation, and ulcers in the lining of your large intestine (also called your colon). There's no cure, and people usually have symptoms off and on for life
definition
layers of the small intestine
parts of the small intestine
functions of the small intestine
types of enteritis
signs and symptoms
complications
diagnose
treatment
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
I am professionally pharmacist. These slides for clinical based those students who study in pharmacy program. These students get more benefits about it.
I am professionally pharmacist. These slides for clinical based those students who study in pharmacy program. These students get more benefits about it.
Inflammatory Bowel Disease is a severe Case in which the peptic ulcers can forn in the bowel or it can cause an inflammation there.
This is Chronic type of disease and mainly target's and affecting the inner lining of GIT that Causes Prolonged inflammation to the GIT
Ulcerative colitis (UC) is an inflammatory bowel disease. It causes irritation, inflammation, and ulcers in the lining of your large intestine (also called your colon). There's no cure, and people usually have symptoms off and on for life
definition
layers of the small intestine
parts of the small intestine
functions of the small intestine
types of enteritis
signs and symptoms
complications
diagnose
treatment
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
1. Ulcerative colitis
Ulcerative colitis is a type of inflammatory bowel disease (IBD) that affects
the lining of the large intestine and rectum. It is a superficial inflammation
of the large intestine, not caused by bacteria, which results in ulceration
and bleeding. Multiple ulcerations and diffuse inflammation occurs in
superficial mucosa and submucosa of colon. Ulcers form where
inflammation has killed the cells that usually line the colon, then bleed and
produce pus. Inflammation in the colon also causes the colon to empty
frequently, causing diarrhea.
When the inflammation occurs in the rectum and lower part of the colon it
is called ulcerative proctitis. If the entire colon is affected it is called
pancolitis. If only the left side of the colon is affected it is called limited or
distal colitis.
2. CAUSES AND RISK FACTORS
The exact cause of ulcerative colitis is unknown. Hereditary, infectious
and immunological factors have been proposed as possible causes.
Stress and certain foods can trigger symptoms; they do not cause
ulcerative colitis. Environmental agents such as pesticides, tobacco,
radiation, and food additives may precipitate an exacerbation. The
disease usually begins in the rectal area, and may involve the entire
large intestine over time. Risk factors include a family history of
ulcerative colitis, or Jewish ancestry.
3. CLINICAL MANIFESTATIONS
Symptoms of ulcerative colitis primarily affect the digestive tract and
include appetite loss, diarrhea, weight loss, rectal bleeding, nausea, and
abdominal cramping. Persistent diarrhea can cause malnutrition,
weakness, and electrolyte imbalances; younger individuals may be small or
or experience delayed growth. A small percentage of those affected may
have symptoms in other body areas or organs.
4. • Pathophysiology:
• The pathophysiology of ulcerative colitis involves an
ongoing cycle of inflammation and tissue damage in the
colon. The immune system overreacts to normal gut
bacteria, triggering an inflammatory response. This immune
response causes increased blood flow to the colon and the
release of various inflammatory substances, leading to tissue
tissue damage and ulcer formation. The chronic
inflammation disrupts the normal functioning of the colon,
resulting in symptoms such as diarrhea, abdominal pain, and
and rectal bleeding.
• The inflammation in UC is primarily limited to the mucosal
layer of the colon, starting in the rectum and potentially
extending proximally to involve other parts of the colon.
5. DIAGNOSTIC EVALUATIONS
Stool specimens are collected for cultivation and microscopy to exclude
infection caused by bacteria and parasites. The diagnosis is confirmed by
means of an endoscopy in the large intestine and the rectum. Small
tissue samples from the mucosa are usually obtained during the
procedure, which can in many cases confirm the diagnosis. An
endoscopic examination of the entire intestine (colonoscopy), flexible
sigmoidoscopy and barium enema X-ray examination can help
determine the extent of the disease. Blood samples can help determine
the severity of the inflammation, and show whether the patient suffers
from anaemia (low haemoglobin count).
6. • Medical management
• Medications: Aminosalicylates: These anti-inflammatory
drugs, such as sulfasalazine and mesalamine, are often used
as first-line therapy for mild-to-moderate UC.
• Corticosteroids: These potent anti-inflammatory
medications may be prescribed for moderate-to-severe UC
to induce remission. However, long-term use is avoided due
to significant side effects.
• Immunomodulators: Drugs like azathioprine,
mercaptopurine, or methotrexate can help reduce
inflammation by suppressing the immune system. They are
used for maintaining remission and reducing the need for
corticosteroids.
7. Biologics: Targeted therapies, including anti-tumor necrosis factor (anti-
TNF) agents (e.g., infliximab, adalimumab), anti-integrin agents (e.g.,
vedolizumab), or Janus kinase (JAK) inhibitors (e.g., tofacitinib), are
prescribed for moderate-to-severe UC when other treatments fail.
Symptomatic Relief:
Anti-diarrheal agents: Medications like loperamide may help control
diarrhea in mild cases.
Pain relievers: Over-the-counter pain medications or prescription drugs
can be used to alleviate abdominal pain or cramping.
Iron supplements: Oral or intravenous iron may be necessary to correct
anemia resulting from chronic bleeding.
8. • Nutritional Support:
• In cases of severe UC, when oral intake is limited, nutritional
supplementation or total parenteral nutrition (TPN) may be
required to provide adequate nutrition.
• Surgery: Surgery may be considered if medical therapy fails,
or in cases of severe complications such as toxic megacolon
or perforation.
• Colectomy (removal of the colon) may be performed, and in
some cases, an ileal pouch-anal anastomosis (IPAA)
procedure may be done to create a pouch from the small
intestine to replace the removed colon.