A 26-year-old male was brought to the ER by EMS after a motorcycle crash where he was not wearing protective gear. He had a swollen face with crepitus and was bleeding from his nose and mouth. After failing to intubate, a cricothyrotomy was performed to secure the airway. Exams found an open femur fracture but otherwise intact. Head, neck, and facial CTs as well as consults to multiple specialties were ordered to further evaluate facial fractures and eye displacement.
Advance life support refer to a constellation of interventions needed to support the vital physiological process during a critical illness, while we await response with definitive therapy. These life support measures are instituted to prevent cardiac arrest.
To recognise physiological derangements that arise out of multiple etiologies and stabilize them first.
EVALUATE – IDENTIFY – INTERVENE
The steps of evaluation are
1.Initial impression
2. Primary assessment
3. Secondary assessment
4. Diagnostic test
Gives insight to overall physiological status and functioning of the brain.
TICLS
Tone: Look for general posture of the child has adopted
Interactive: Is the child responsive and interacting appropriately, unresponsive or lethargic.
Consolable: Irritable, consolable or inconsolable
Look\Gaze: How is the child looking at mother, any vacant gaze
Speech: Is the child able to speak or vocalise as is appropriate for age or is there a paucity\weak\hoarseness of voice.
IDENTIFY = Abnormality in any of these parameters point towards a brain dysfunction
Impaired consciousness is a significant alteration in the awareness of self and environment with varying degree of wakefulness.
Unconsciousness persisting for at lest 1 hr – Coma.
Younger children more likely to have coma or altered sensorium secondary to non-traumatic etiology, where as traumatic brain injury is more common in older children.
Always rule out reversible causes of coma, like hypoglycemia, hyperglycaemia and electrolyte imbalance.
Any severe systemic illness can cause altered consciousness as a result of hypoxic ischemic insult, which if on-going can aggravate raised ICT.
Advance life support refer to a constellation of interventions needed to support the vital physiological process during a critical illness, while we await response with definitive therapy. These life support measures are instituted to prevent cardiac arrest.
To recognise physiological derangements that arise out of multiple etiologies and stabilize them first.
EVALUATE – IDENTIFY – INTERVENE
The steps of evaluation are
1.Initial impression
2. Primary assessment
3. Secondary assessment
4. Diagnostic test
Gives insight to overall physiological status and functioning of the brain.
TICLS
Tone: Look for general posture of the child has adopted
Interactive: Is the child responsive and interacting appropriately, unresponsive or lethargic.
Consolable: Irritable, consolable or inconsolable
Look\Gaze: How is the child looking at mother, any vacant gaze
Speech: Is the child able to speak or vocalise as is appropriate for age or is there a paucity\weak\hoarseness of voice.
IDENTIFY = Abnormality in any of these parameters point towards a brain dysfunction
Impaired consciousness is a significant alteration in the awareness of self and environment with varying degree of wakefulness.
Unconsciousness persisting for at lest 1 hr – Coma.
Younger children more likely to have coma or altered sensorium secondary to non-traumatic etiology, where as traumatic brain injury is more common in older children.
Always rule out reversible causes of coma, like hypoglycemia, hyperglycaemia and electrolyte imbalance.
Any severe systemic illness can cause altered consciousness as a result of hypoxic ischemic insult, which if on-going can aggravate raised ICT.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. Scenario
A 26 year old male brought in by EMS with C-collar and non-
rebreather face mask.
EMS states two motor cycles crashed and he was not wearing
a helmet or other protective gear.
BP 100/70 HR 130 RR 30 O2 sat 90%
3. ABC’s
A with C-spine – patient obtunded, gurgling with blood coming from nose
and mouth
Visual: swollen face, palpation –crepitus, when grab front teeth, upper face
moves
Rx – suction, jaw thrust, oral airway only if tolerates, gently placed
Patient improves a bit but soon, gurgling with back of throat filled with
blood
Call for back-up!
Must secure airway - ? Awake intubation – gags fighting
blood obscures vision – since difficult airway, consider Ketamine
1mg/kg with increments of .5mg/kg up to 2mg/kg total
4. Airway
Difficult – no RSI
Ketamine calms and BP and respiratory reflexes still intact
may cause increased oral secretions with higher doses
Back up equipment available, i.e. Bougie? Crico kit??
although LMA may actually help to tamponade upper source
of bleeding, since don’t know where bleeding is located,
would require a better more definitive airway plan.
5. Unable to visualize and intubate
O2 sat dropping now 80% with decreased visualization.
Only option: cricothryroidotomy
may use hook or bougie for placement but if don’t have hook, increased
chance of creating a false path
What size tube??
a pediatric 5.0 can be used to oxygenate and ventilate an average adult,
can change after airway secured (outer diameter should be smaller than
9mm because height of membrane is only 9mm…smaller in women
- average 7.5 tube has an outer diameter of >10 10mm, using this size
would increase likelihood of fracturing cartilage and leave pat with
permanent dysphonia.
6. Location, Location, Location!
1. For thin males –
locate Adam’s Apple - the
(prominent V-notch
at the top of the
thryroid cartilage).
2. Slide finger
inferiorly until find
second bump – the
cricoid cartilage.
3. Membrane just
cephalad to cricoid.
8. How do you perform crico
Location, location, location
slide finger up form sternal notch
if thryroid not enlarged, the first firm jugging structure is the
cricoid. Make a horizontal cut about a cm wide if you know
where you are.
If not start with vertical cut and locate membrane first
Open only front of c-collar and have someone stabilze neck
10. Membrane Location in
Females/Children
- Slide finger cephalad from the sternal notch.
- Cricoid cartilage juts past tracheal rings.
- Easy to find first bump jutting past rings if
no thyroid disease.
- Note: may be the only “bump” found in the neck
of woman/children.
11. Prepare a Crico Kit
Scalpel
Tracheal Hook
Trousseau Dilator (or Kelly clamp)
Cuffed Tracheostomy tube
(Bougie may substitute for dilator)
12. Tracheostomy Tube Size
Recommended Adult Crico tube size:
- ID (inner diameter) 5.0 mm or 6.0 mm
- OD (outer diameter) should be less than 9 mm
WHY?
Height of the cricothyroid membrane at widest
vertical point: 9 mm in adult (average)
13. Why Small Cricothyrotomy Tube Size?
Note: This endotrachal tube that has an internal diameter
of 7.5 mm and an outer diameter of 10.3 mm.
Placing a larger tube in the crico opening:
1. increases likelihood of thyroid cartilage fracture
2. increases the likelihood of creating a false passage.
14. Tracheostomy Tube Size
A 5mm ID tube is generally used for a
small child, but can adequately ventilate an
adult if needed.
Most important – place a tube to oxygenate.
Change tube size later.
Walls RM and Murphy MF: Manual of Emergency Airway Management,
4th Edition, Philadelphia, Lippincott, Williams and Wilkins, 2012.
15. Quick Technique
1. Vertical incision thru skin
only if can’t locate membrane.
2. Horizontal (1cm) incision
thru cricoid, dilate vertically.
3. Lift the cricoid cartilage – not the thyroid
cartilage – with the tracheal hook, as if using a
laryngoscope. (Reduces chance of false passage).
4. Insert tube with twisting motion.
17. Circulation
BP 100/70 HR 120 , active bleeding form open femur fx
Pelvis intact and no other external bleeding
Sono – good cardiac, IVC OK, FAST negative
Rx – IV X 2 liters, Tand C
- direct pressure over femur bleeding site – but do not
insert, needs OR for cleansing (order IV Cephalorsporin as
preventiion)
place on monitor and check rhythm strip – sinus tachycardia
18. Disability
- Does not open eyes to calling name or pain (swollen)
- Random moans
- Withdrawal to painful stimuli in all extremities
GCS: +1, +2, +4 = 7
Unabke to assess pupils since lids beginning to swell
tightly, options??
19. Bemt paper clips to open eyes – used outer lids but can also
be used to lift the lids from underneath!
Cheng LHH et al. Retraction of Oedematous Eyelids with Paper-Clips,
Ann R Coll Surg Engl. 2008 Apr; 90(3): 253.
20. Expose and
Primary Survey Adjuncts
Log roll and undress – no other lesions
Adjunts – Foley – after assessing for groin/pelvic trauma –
non bloody urine . Empty bag and start recording urine
output – needs 0.5 to 1 ml/kg/hour to be adequately
volume resuscitated
NGT – do not place thru nose – mouth with observation going
in correct direction
If CXR not yet done after intubation, call for CXR and pelvis
21. AMPLE
Allergies: Pen and Cephalosporin –anaphylaxisis
Meds: none
PMH: hospitalized for analphylaxsis
Last meal: unknown
Events: bystanders told EMS racing with friends and
hit bike that stopped short and was trhown further
His phone had number for “mom” and hx obtained
from mother.
22. Calling Consults or Transfers
If surgery has not already been called, must be called
now!
Neurosurgery, OMFS and ophthomology and
orthopedics should all be alerted.
23. Secondary Survey
HEENT: PERLL, unable to assess EOM but light reflex in
different portion of cornea suggesting dysconjugate gaze or
displacement of eyeball , +facial SQ emphysema palpable,
crepitus felt around the facial bones, marked swelling,
oozing blood from nose, bridge of nose unstable, TM’s
blood behind Rt side
Neck: WNL
Lungs: WNL RR per ventilator, O2 sat 94% on 40% FiO2
CVS: after 2 liters, BP 120/80 HR 110
Abd: +BS, unable to assess pain
Ext: open Rt femur Fx
Neuro: sedated on vent, no change
24. What ancillary tests?
CT head, neck, abd
CT facial views – different from head CT and better than
facial Xrays
If facial Xrays: use Waters view and Jug handle views
28. Critical or Important Actions
1. Assesses and manages airway compromise appropriately
and in a timely manner.
2. Searches for source of bleeding and controls external
bleeding
3. Obtains Hx of allergies/anaphylaxis and gives different
med for open fx prophylaxis
4. Dx Le Forte Fx and obtains facial CT in addition to head
CT and contacts appropriate consultation
6. Dx possible basilar skull fx from hemotypamum
7. Examines eye and recognizes displacement by light reflex
abnormalities and contacts ophthalmology