This document provides an overview of transdermal drug delivery systems (TDDS). It defines TDDS and lists their advantages over other delivery methods. The basic components of TDDS are described, including polymer matrices, drugs, permeation enhancers, and other excipients. Several formulation approaches for TDDS are outlined, such as membrane permeation-controlled systems and matrix diffusion-controlled systems. Methods for evaluating TDDS are mentioned, including drug-excipient interaction studies, weight uniformity testing, percentage moisture content testing, drug content analysis, moisture loss testing, and skin irritation testing. The document concludes by citing two review articles on TDDS.
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
Approaches Of Gastro-Retentive Drug Delivery System
Includes:
Floating and Non-Floating drug delivery system with their subtypes
Like Non-effervescent system, Effervescent system, Raft forming system,
High Density system, Expandable system, Muco-adhesive system,
Super porous hydrogel system and Magnetic Systems, etc.
SUSTAINED RELEASE (SR) & CONTROL RELEASE.pptxRAHUL PAL
Sustained-release medications are usually labeled with “SR” at the end of their name. These medications prolong the medication's release from a tablet or capsule so that you'll get the medication's benefits over a longer period of time.
CR = controlled release, SR = sustained release, ER = extended release, IR = immediate release. *
Formulation and evaluation of transdermal drug delivery system (TDDS)SanketPawar47
This is slide about formulation and evaluations of transdermal drugs delivery system . Introduction , general structure of TDDS , basic components of TDDS , approch for formulation of TDDS , manufacturing processes for TDDS ,and evaluations of TDDS
Gastro retentive drug delivery system (GRDDS)Ravish Yadav
gastro retentive drug delivery system topic include
1. introduction
2.advantages
3.technology
4.evaluation
5.disadvantages
6. matrix tablet
and other relative information regarding the topic
SUSTAINED RELEASE (SR) & CONTROL RELEASE.pptxRAHUL PAL
Sustained-release medications are usually labeled with “SR” at the end of their name. These medications prolong the medication's release from a tablet or capsule so that you'll get the medication's benefits over a longer period of time.
CR = controlled release, SR = sustained release, ER = extended release, IR = immediate release. *
Formulation and evaluation of transdermal drug delivery system (TDDS)SanketPawar47
This is slide about formulation and evaluations of transdermal drugs delivery system . Introduction , general structure of TDDS , basic components of TDDS , approch for formulation of TDDS , manufacturing processes for TDDS ,and evaluations of TDDS
Gastro retentive drug delivery system (GRDDS)Ravish Yadav
gastro retentive drug delivery system topic include
1. introduction
2.advantages
3.technology
4.evaluation
5.disadvantages
6. matrix tablet
and other relative information regarding the topic
Transdermal drug delivery system (TDDS) it's formulation and evaluationShritilekhaDash
Topics included:- Introduction; General structure and basic components of TDDS; Types of TDDS; Formulation; Evaluation and it's types; Market share; Examples; Merits and demerits;
TDDS, Anatomy of Skin, Advantages and disadvantages,Permeation of Drug Molecule through Skin, Factors affecting Transdermal Permeation, Design of transdermal system, Evaluation of TDDS
Transdermal drug delivery are defined as a self contained discrete dosage form which, when applied to the intact skin, will deliver the drug at a controlled rate to the systemic circulation.
its also known popularly as “patches”
1)Introduction
2)Advantages and Disadvantages
3)Structure of Skin
4)Permeation through skin
5)Factors affecting permeation
6)Basic Componentes of TDDS
7)Formulation approaches used in the development of TDDS
8)Evaluation of TDDS
9)Reference
Criticisms of orthodox medical ethics, importance ofsupriyawable1
ethics is a very large and complex field of study with many branches .medical ethics is the branch of ethics that deals moral issues in medical practice. principles of medical ethics - autonomy ,beneficence ,confidentiality,do not harm,equity .importance of communication .
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. Presented by : Miss . Supriya Wable.
M.Pharm,1st Year
Dept : Pharmaceutics
Dattakala collgege of pharmacy
Date:
3. Introduction
Advantages
Basic components
Formulation approaches used in TDDS
Evaluation of TDDS
Reference
4. Definition –
Transdermal therapeutic systems are defined as self
contained ,self discrete dosage forms ,which when
applied to the intact skin deliver the drug at a
controlled rate to the systemic circulation.
A simple patch that you stick onto your skin like an
adhesive bandage, which utilize passive diffusion of
drugs across the skin as the delivery mechanism.
5. It delivers a steady infusion of the drug over an
extended period of time .
Adverse effects and therapeutic failures can be
avoided
It increases the therapeutic value of many drugs by
avoiding specific problems associated with the drug .
The simplified medication regimen leads to an
improved patient compliance and reduce inter patient
and intra patient variability.
Self medication is possible with this type of system.
6. The components of the transdermal drug delivery
system include –
1. Polymer matrix or matrices
2. The drug
3. The permeation enhancers
4. Other excipients
7. 1.Polymer matrix
It releases the drug from the device and should
satisfy the following criteria-
ii. Molecular weight , chemical functionality of the
polymer should be such that specific drug diffuses
properly and gets released through it.
iii. It should be stable , non reactive with the drug,
easily manufactured and fabricated into the desired
productiv.
The polymer and its degradation products must be non
toxic or non antagonistic to the host .
8. 2.Drug
Biological properties –
The drug should be potent with a daily dose of order of
a few mg/ day.
The half life of the drug should be short.
The drug must not induce a cutaneous irritant or
allergic response.
Drugs degraded in the GIT or inactivated by the
hepatic first pass are suitable candidates for
transdermal drug delivery.
9. 3.Permeation enhancers
These are compounds which promote skin
permeability by altering the skin as a barrier to the
flux of the desired penetrant .
The flux of the drug (J) is given by-
J= dc J D dx
D= diffusion coefficient
C = conc. of the diffusing species
X= spatial coordinate
10. 4. Other excipients
Adhesives –
The fastening of the transdermal device is usually
done by the adhesive .
The adhesive should satisfy the following criteria .
Do not irritate or sensitize the skin.
Adhere to the skin during the dosing interval.
It should be easily removed .
It should not leave any unwashable residue.
11. Backing membrane
They are flexible and provide a good bond to the drug
reservoir , prevent the drug from leaving the dosage
form through top.
It is an impermeable membrane that protects the
product during the use on the skin.• Contains
formulation throughout shelf-life and during wear
period• Must be compatible with formulation
(nonadsorptive)
Printable
Eg: metallic plastic laminate , plastic backing with
adsorbent .
12. 1. Membrane permeation – controlled systems
2. Adhesive dispersion – type systems.
3. Matrix diffusion – controlled systems.
4. Microreservoir type or Microsealed dissolution –
controlled systems.
5. Poroplastic – type systems.
6.Transdermal delivery of Macromolecules.
13. 1.Membrane permeation – controlled systems
The drug reservoir is totally encapsulated in a
shallow compartment moulded from a drug –
impermeable metallic plastic laminate & a rate
controlling polymeric membrane which may be
microporous or non-porous.
The rate of drug release from this type of TDDS can
be tailored by varying the composition of polymer,
permeability coefficient, thickness of the rate limiting
membrane & adhesive.
14.
15. 2.Adhesive dispersion – type systems
The drug reservoir is formulated by directly
dispersing the drug in an adhesive polymer & then
spreading the medicated adhesive by hot melt, on to a
flat sheet of drug impermeable metallic plastic
backing to form a thin drug reservoir layer.
Example: Isosorbide dinitrate-releasing Transdermal
therapeutic system (Frandol tape) for once a day
medication of angina pectoris.
16.
17. 3. Matrix diffusion – controlled system
i) It is prepared by homogeneously dispersing the drug
particles with a liquid polymer or a highly viscous base
polymer followed by cross linking of the polymer chains or
homogeneously blending the drug solids with a rubbery
polymer at an elevated temp.
ii) It can also be prepared by dissolving the drug & polymer in
a common solvent followed by solvent evaporation in a
mould at an elevated temp. or in a vaccum.
iii) It is then pasted on to an occlusive base plate in a
compartment fabricated from a drug impermeable plastic
backing, the adhesive polymer is then spread along the
circumference to form a strip of adhesive rim around the
medicated disc.
18.
19. 4. Microreservoir type or Microsealed dissolution –
controlled systems
This is the combination of reservoir & matrix
diffusion type drug delivery systems.
Drug reservoir is formed by first suspending the drug
solids in an aqueous solution of a water soluble liquid
polymer & then dispersing the drug suspension
homogeneously in a lipophilic polymer such as silicone
elastomers by high dispersion technique.
Example: Nitroglycerine-releasing Transdermal
system (Nitro disc) for once a day therapy of angina
pectoris.
20.
21. 5. Poroplastic– type systems
It is made utilizing the concept of the water
coagulation of cellulose triacetate solution in organic
acids at low temp.
The coagulation is performed under controlled
condition.
The water may be exchanged subsequently for
another vehicle by a diffusional exchange process, &
hence it is also known as “solid composed mostly of
liquid.”
22. 6. Transdermal delivery of Macromolecules
Macromolecules such as Hormones, interferons,
bioactive peptides can be deliver by Transdermal
delivery system.
The devices used for this purpose are divided in to two
categories…. a. Devices based on ethylene vinyl
acetate copolymers (EVAc).
Devices based on silicone elastomers.
This both the systems utilize one common concept i.e.
matrix must have channels to facilitate the release of
macromolecules.
These devices are used as implants.
23. 1.Drug excipient interaction studies
Interaction studies are commonly carried out using
thermal analysis, FT-IR studies, UV and
chromatographic techniques by comparing their
physicochemical characters such as assay, melting
endotherms, characteristic wave numbers and
absorption maxima etc.
24. 2.weight uniformity
The prepared patches are dried at 60o c for 4 hrs
before testing.
A specified area of patch is to be cut in different parts
of the patch and weight in digital balance.
The avg weight and standard deviation values are to
be calculated from the individual weights.
25. 3.percentage moisture content
The prepared patches are cut into strips of specific
size. The strips are then weighed individually and kept
in a dessicator containing activated silica at 300c for 12
hrs. The films are reweighed individually until a
constant weight is obtained.
%moisture content =loss in wt/initial wt ×100
26. 4.drug content
The specified films are to be dissolved in a suitable
solvent in specific volume.
Then the solution is to be filterd through a filter
medium and analyze the drug contain with the suitable
method.
Each value avg of three different samples.
27. 5. Moisture loss
The prepared films are to be weighed individually
and to be kept in a dessicator containing calcium
chloride at 40c .
After 24 hrs the films are to be reweighed and
determine the percentage of moisture loss from the
below formula.
%moisture loss =initial wt -final wt /final wt ×100
28. 6. Skin irritation test
This test can be performed on healthy rabbits.
The dorsal surface of the rabbit is to be cleaned and
remove the hair from the clean dorsal surface by shaving
and clean the surface by using rectified spirit and the
representative formulations can be observed and
classified into 5 grades on the basis of the severity of skin
injury.
29. Anna M wokovich,suneela proddutari ,willam H
doub; review article on transdermal drug delivery
system by European journal of pharmaceutics and
biopharmaceutics, 2006.
Mark Road prausnitz; reviews article on
microneedles forum transversal drug delivery by
advanced drug delivery reviews,2004.