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Mr. Rahul Pal* (๐‘Œ๐‘œ๐‘ข๐‘›๐‘” ๐‘†๐‘๐‘–๐‘’๐‘›๐‘ก๐‘–๐‘ ๐‘ก), profile picture
Uploaded byMr. Rahul Pal* (๐‘Œ๐‘œ๐‘ข๐‘›๐‘” ๐‘†๐‘๐‘–๐‘’๐‘›๐‘ก๐‘–๐‘ ๐‘ก)
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SUSTAINED RELEASE (SR) & CONTROL RELEASE.pptx

The document discusses sustained release (SR) and controlled release (CR) drug delivery systems, highlighting their differences in release kinetics, with SR following first-order kinetics and CR following zero-order kinetics. SR is designed for prolonged therapeutic effect, while CR maintains constant drug levels in the bloodstream. Advantages of these drug delivery systems include reduced side effects and improved bioavailability, while disadvantages involve issues like dose dumping and higher costs.

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Prachi Pandeyโ€ขPharmaceutical Analysisโ€ข
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SUSTAINED RELEASE (SR) & CONTROLLED RELEASE (CR) SUBMITTED BY: RAHUL PAL, PRACHI PANDEY SUBMITTED TO: ARSH CHANANA M. PHARM (PHARMACEUTICS) NIMS INSTITUTE OF PHARMACY, NIMS UNIVERSITY JAIPUR, RAJASTHAN INDIA
SUSTAINED RELEASE (SR) The Sustained release are majorly designed to achieve the prolonged therapeutic effect by continuously releasing medication over the extended period of time usually 8-12 hr., after single dose administration. ๏‚ก Especially they provide the medication over extended time of period. ๏‚ก SR release follow 1st order release kinetics, means depends on concentration. ๏‚ก In Other words, โ€œThe slow release of drug substances from a dosage form to maintain therapeutic responses for extended period of timeโ€. Example: Aspirin, Dextrin SR.
CONTROLLED RELEASE (CR) The delivery of the drug medicament at predetermined rate, for locally and systematically for specified period of time, known as โ€œControlled releaseโ€. ๏‚ก Maintain the constant drug level in the blood as well as tissues. ๏‚ก CR release follow Zero order release kinetic, means independence of concentration. ๏‚ก In short words, โ€œ The formulation which delivers the drug at predetermined rate.โ€ Example: GITS (Prazosin), Morphine Sulphate (Roxonal SRยฎ)
GRAPHICAL REPRESENTATION OF SR/CR CONTROLLED RELEASED (CR) SUSTAINED RELEASED (SR)
STUDY OVERVIEW OF DRUG RELEASE
DIFFERENCE BETWEEN SR/CR SUSTAINED RELEASE (SR) ๏ƒ˜ Dosage form that provide medication over extended period of time. ๏ƒ˜ Follow 1st order release kinetics. ๏ƒ˜ Usually do not promote localization of the drug at active site. ๏ƒ˜ Drug release at programmed rate, dependent on external environmental. CONTROLLED RELEASE (CR) ๏ƒ˜ Dosage form that maintains constant drug levels in the blood/tissue. ๏ƒ˜ Follow zero order release kinetics. ๏ƒ˜ Usually promote localization of the drug at active site. ๏ƒ˜ Drug release at predetermined rate, independent of external environmental.
ADVANTAGES OF SR/CR DRUG DELIVERY a) Reduced GI side effects, and dosing frequency. b) Improve absorption, enhancing the bioavailability (BA). c) Bateer patients acceptance and compliance. d) Decreased the local and systemic side effect. e) Minimized the accumulation of drug medicament with chronic dosing.
DISADVANTAGES OF SR/CR DRUG DELIVERY a) Dose dumping problem occurred. b) Stability problem. c) Cost of single unit dosage form is higher than that of conventional dosage form. d) Poor In-vitro & In-Vivo correction. e) Dose adjustment sometime difficult. f) Patient education is required for the successful therapy.
FACTORS AFFECTING THE SR/CR DRUG RELEASE
APPROACHES IN SR/CR DDS
DISSOLUTION CONTROLLED RELEASE
DIFFUSION CONTROLLED RELEASE
APPLICATION OF SR/CR